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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Languages: English
Types: Doctoral thesis
Subjects: QD
This thesis describes studies into the synthesis of the batzelladine alkaloids including a detailed study into the synthesis of alkylidenepyrrolidines. Chapter 1 is a brief introduction to the batzelladine alkaloids highlighting all significant work carried out since their isolation in the mid 1990's. Chapter 2 looks at the viability of Lewis acid promoted Friedel-Crafts reactions for the formation of quinolones, and the usefulness of this reaction to the synthesis of batzelladine alkaloids. Chapter 3 includes a detailed methodology study into the formation of alkylidenepyrrolidines, and the reasons why a new synthesis is required. Chapter 4 investigates the Kishi three-component coupling reaction, including a mechanistic study and a synthetic study. Chapter 5 describes our work into the synthesis of batzelladine C and incorporates the work carried out and detailed in Chapters 2 and 3.

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