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Publisher: BioMed Central Ltd.
Languages: English
Types: Article
Subjects: RG
Background\ud Pregnancies complicated by pre-existing diabetes mellitus (PDM) are associated with a high rate of adverse outcomes, including an increased miscarriage rate, preterm delivery, preeclampsia, perinatal mortality and congenital malformations; compared to the background population. The objectives of this study are to determine the prevalence of PDM and to investigate the maternal and the neonatal outcomes of women with PDM.\ud \ud Methods\ud This is a retrospective cohort study for women who delivered in King Khalid University Hospital (KKUH) during the period of January 1st to the 31st of December 2008. The pregnancy outcomes of the women with PDM were compared to the outcomes of all non-diabetic women who delivered during the same study period.\ud \ud Results\ud A total of 3157 deliveries met the inclusion criteria. Out of the study population 116 (3.7%) women had PDM. There were 66 (57%) women with type 1 diabetes mellitus (T1DM) and 50 (43%) women with type 2 diabetes mellitus (T2DM). Compared to non-diabetic women those with PDM were significantly older, of higher parity, and they had more previous miscarriages. Women with PDM were more likely to be delivered by emergency cesarean section (C/S), OR 2.67, 95% confidence intervals (CI) (1.63-4.32), P < 0.001, or elective C/S, OR 6.73, 95% CI (3.99-11.31), P < 0.001. The neonates of the mothers with PDM were significantly heavier, P < 0.001; and more frequently macrosomic; OR 3.97, 95% CI (2.03-7.65), P = 0.002. They more frequently have APGAR scores <7 in 5 minutes, OR 2.61, 95% CI (0.89-7.05), P 0.057 and more likely to be delivered at <37 gestation weeks, OR 2.24, 95% CI (1.37- 3.67), P 0.003. The stillbirth rate was 2.6 times more among the women with PDM; however the difference did not reach statistical significance, P 0.084.\ud \ud Conclusion\ud PDM is associated with increased risk for C/S delivery, macrosomia, stillbirth, preterm delivery and low APGAR scores at 5 min.
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    • 1. Wild S, Roglic G, Green A, Sicree R, King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27:1047-1053.
    • 2. Verheijen EC, Critchley JA, Whitelaw DC, Tuffnell DJ: Outcomes of pregnancies in women with pre-existing type 1 or type 2 diabetes, in an ethnically mixed population. BJOG 2005, 112:1500-1503.
    • 3. Chaudhry T, Ghani AM, Mehrali TH, Taylor RS, Brydon PA, Gee H, et al: A comparison of foetal and labour outcomes in Caucasian and Afro-Caribbean women with diabetes in pregnancy. Int J Clin Pract 2004, 58:932-936.
    • 4. Ryan EA, Enns L: Role of gestational hormones in the induction of insulin resistance. J Clin Endocrinol Metab 1988, 67:341-347.
    • 5. Lapolla A, Dalfra MG, Di CG, Bonomo M, Parretti E, Mello G: A multicenter Italian study on pregnancy outcome in women with diabetes. Nutr Metab Cardiovasc Dis 2008, 18:291-297.
    • 6. Macintosh MC, Fleming KM, Bailey JA, Doyle P, Modder J, Acolet D, et al: Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study. BMJ 2006, 333:177.
    • 7. Balsells M, Garcia-Patterson A, Gich I, Corcoy R: Maternal and fetal outcome in women with type 2 versus type 1 diabetes mellitus: a systematic review and metaanalysis. J Clin Endocrinol Metab 2009, 94:4284-4291.
    • 8. Mills JL, Baker L, Goldman AS: Malformations in infants of diabetic mothers occur before the seventh gestational week. Implications for treatment. Diabetes 1979, 28:292-293.
    • 9. Wahabi HA, Alzeidan RA, Bawazeer GA, Alansari LA, Esmaeil SA: Preconception care for diabetic women for improving maternal and fetal outcomes: a systematic review and meta-analysis. BMC Pregnancy Childbirth 2010, 10:63.
    • 10. Syed M, Javed H, Yakoob MY, Bhutta ZA: Effect of screening and management of diabetes during pregnancy on stillbirths. BMC Public Health 2011, 11(Suppl 3):S2.
    • 11. National Collaborating Centre for Women's andChildren's Health: Diabetes in pregnancy. Revised reprint. London: RCOG Press; 2008.
    • 12. El Mallah KO, Narchi H, Kulaylat NA, Shaban MS: Gestational and pregestational diabetes: comparison of maternal and fetal characteristics and outcome. Int J Gynaecol Obstet 1997, 58:203-209.
    • 13. Al Najashi SS, Al Umran KU: Congenital anomalies among infants of diabetic mothers: a study of 466 cases at King Fahd Hospital of the University, Al-Khobar. J Obstet Gynaecol 1997, 17:23-25.
    • 14. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yousef M, Sabico SL, et al: Diabetes mellitus type 2 and other chronic non-communicable diseases in the central region, Saudi Arabia (riyadh cohort 2): a decade of an epidemic. BMC Med 2011, 9:76.
    • 15. Barakat MN, Youssef RM, Al-Lawati JA: Pregnancy outcomes of diabetic women: charting Oman's progress towards the goals of the Saint Vincent Declaration. Ann Saudi Med 2010, 30:265-270.
    • 16. Bell R, Bailey K, Cresswell T, Hawthorne G, Critchley J, Lewis-Barned N: Trends in prevalence and outcomes of pregnancy in women with pre-existing type I and type II diabetes. BJOG 2008, 115:445-452.
    • 17. Shand AW, Bell JC, McElduff A, Morris J, Roberts CL: Outcomes of pregnancies in women with pre-gestational diabetes mellitus and gestational diabetes mellitus; a population-based study in New South Wales, Australia, 1998-2002. Diabet Med 2008, 25:708-715.
    • 18. Dunne F, Brydon P, Smith K, Gee H: Pregnancy in women with Type 2 diabetes: 12 years outcome data 1990-2002. Diabet Med 2003, 20:734-738.
    • 19. Bond MJ, Umans JG: Microvascular complications and the diabetic pregnancy. Curr Diab Rep 2006, 6:291-296.
    • 20. Ehrenstein V, Pedersen L, Grijota M, Nielsen GL, Rothman KJ, Sorensen HT: Association of Apgar score at five minutes with long-term neurologic disability and cognitive function in a prevalence study of Danish conscripts. BMC Pregnancy Childbirth 2009, 9:14.
    • 21. Rackham O, Paize F, Weindling AM: Cause of death in infants of women with pregestational diabetes mellitus and the relationship with glycemic control. Postgrad Med 2009, 121:26-32.
    • 22. El FC, Mourali M, Ouerdiane N, Oueslati S, Hadj HA, Chaabene M, et al: Maternal and fetal outcomes of large fetus delivery: A comparative study. Tunis Med 2011, 89:553-556.
    • 23. Van EP: Obesity in pregnancy. S D Med 2011, Spec No:46-50.
    • 24. Ojule JD, Fiebai PO, Okongwu C: Perinatal outcome of macrosomic births in Port Harcourt. Niger J Med 2010, 19:436-440.
    • 25. Denguezli W, Hemdane S, Faleh R, Laajili H, Saidan Z, Haddad A, et al: Prevalence and risk factors of cesarean section in a population of Tunisian diabetic pregnant women. Tunis Med 2007, 85:935-940.
    • 26. Conway DL, Langer O: Elective delivery of infants with macrosomia in diabetic women: reduced shoulder dystocia versus increased cesarean deliveries. Am J Obstet Gynecol 1998, 178:922-925.
    • 27. Stuart AE, Matthiesen LS, Kallen KB: Association between 5 min Apgar scores and planned mode of delivery in diabetic pregnancies. Acta Obstet Gynecol Scand 2011, 90:325-331.
    • 28. Rouse DJ, Owen J, Goldenberg RL, Cliver SP: The effectiveness and costs of elective cesarean delivery for fetal macrosomia diagnosed by ultrasound. JAMA 1996, 276:1480-1486.
    • 29. Kock K, Kock F, Klein K, Bancher-Todesca D, Helmer H: Diabetes mellitus and the risk of preterm birth with regard to the risk of spontaneous preterm birth. J Matern Fetal Neonatal Med 2010, 23:1004-1008.
    • 30. Bental Y, Reichman B, Shiff Y, Weisbrod M, Boyko V, Lerner-Geva L, et al: Impact of Maternal Diabetes Mellitus on Mortality and Morbidity of Preterm Infants (24-33 Weeks' Gestation). Pediatrics 2011, 128(4):e848-855.
    • 31. Murphy HR, Steel SA, Roland JM, Morris D, Ball V, Campbell PJ, et al: Obstetric and perinatal outcomes in pregnancies complicated by Type 1 and Type 2 diabetes: influences of glycaemic control, obesity and social disadvantage. Diabet Med 2011, 28:1060-1067.
    • 32. Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, Damm P, et al: International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010, 33:676-682.
    • 33. de Valk HW, Visser GH: Insulin during pregnancy, labour and delivery. Best Pract Res Clin Obstet Gynaecol 2011, 25:65-76.
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