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Publisher: Wiley
Languages: English
Types: Article
Subjects: QD, RA1001
Identifiers:doi:10.1002/dta.1790
Phenazepam is a benzodiazepine that is predominantly used clinically in the former Soviet\ud states but throughout the wider world is being abused. This study reports the tissue\ud distribution and concentration of both phenazepam and 3-hydroxyphenazepam in 29 cases\ud quantitated by LC-MS/MS in a variety of postmortem fluids (subclavian blood, femoral\ud blood, cardiac blood, urine, vitreous humor) and tissues (thalamus, liver and psoas\ud muscle). In 27 cases the cause of death was not directly related to phenazepam (preserved\ud (fluoride/oxalate) femoral blood phenazepam concentrations 0.007 mg/L to 0.360 mg/L\ud (median 0.097 mg/L)). In two cases phenazepam was either a contributing factor to, or the\ud certified cause of death (preserved (fluoride/oxalate) femoral blood 0.97 mg/L and 1.64\ud mg/L). The analysis of phenazepam and 3-hydroxyphenazepam in this study suggests that\ud they are unlikely to be subject to large postmortem redistribution and that there is no direct\ud correlation between tissues/fluid and femoral blood concentrations. Preliminary\ud investigations of phenazepam stability comparing femoral blood phenazepam\ud concentrations in paired preserved (2.5% fluoride/oxalate) and unpreserved blood show\ud that unpreserved samples show on average a 14% lower concentration of phenazepam\ud and we recommend that phenazepam quantitation is carried out using preserved samples\ud wherever possible.
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    • c w n o o l c e l B l iv in t r U a ow itt h n s a s u n q o f i n ilm e c w n o o l c e l B l Maskell, P.D., et al., Phenazepam: the drug that came in from the cold. Journal of forensic and legal medicine, 2012. 19(3): p. 122-125.
    • Phenazepam. 4th February 2015]; Available from: http://pharmabook.net/en/neyrotropnye-sredstva/anksiolitiki/phenazepam.html.
    • Kopanitsa, M.V., et al., Modulation of GABAA receptor-mediated currents by phenazepam and its metabolites. Naunyn-Schmiedeberg's archives of pharmacology, 2001. 364(1): p. 1-8.
    • Corkery, J.M., F. Schifano, and A.H. Ghodse, Phenazepam abuse in the UK: an emerging problem causing serious adverse health problems, including death. Hum Psychopharmacol, 2012. 27(3): p. 254-61.
    • Maskell, P.D., et al., Phenazepam is currently being misused in the UK. BMJ, 2011.
    • 343(jul05): p. d4207-d4207.
    • Stephenson, J.B., D.E. Golz, and M.J. Brasher, Phenazepam and its effects on driving. J Anal Toxicol, 2013. 37(1): p. 25-9.
    • J Anal Toxicol, 2010. 34(8): p. 527-32.
    • Kriikku, P., et al., Phenazepam abuse in Finland: findings from apprehended drivers, post-mortem cases and police confiscations. Forensic Sci Int, 2012. 220(1-3): p.
    • Couch, R.A. and H. Madhavaram, Phenazepam and cannabinomimetics sold as herbal highs in New Zealand. Drug Test Anal, 2012. 4(6): p. 409-14.
    • Gjerde, H., et al., Toxicological investigations of drivers killed in road traffic accidents in Norway during 2006-2008. Forensic Sci Int, 2011. 212(1-3): p. 102-9.
    • Flanagan, R., A. Amin, and W. Seinen, Effect of post-mortem changes on peripheral and central whole blood and tissue clozapine and norclozapine concentrations in the domestic pig (< i> Sus scrofa). Forensic science international, 2003. 132(1): p. 9- 17.
    • Maskell, P.D., et al., Mephedrone (4-methylmethcathinone)-related deaths. J Anal Toxicol, 2011. 35(3): p. 188-91.
    • Peters, F.T., O.H. Drummer, and F. Musshoff, Validation of new methods. Forensic science international, 2007. 165(2): p. 216-224.
    • Analytical Chemistry, 2003. 75(13): p. 3019-3030.
    • Kerrigan, S., M.B. Mellon, and P. Hinners, Detection of phenazepam in impaired driving. Journal of analytical toxicology, 2013. 37(8): p. 605-610.
    • Burch, H.J., et al., Concentrations of drugs determined in blood samples collected from suspected drugged drivers in England and Wales. Journal of forensic and legal medicine, 2013. 20(4): p. 278-289.
    • Johnson, W. Phenazepam in Wisconsin drivers. in annual meeting of the Society of Forensic Toxicologists. Society of Forensic Toxicologists Inc. One MacDonald Center. 2010.
    • Karinen, R., et al., Lethal poisonings with AH-7921 in combination with other substances. Forensic science international, 2014. 244: p. e21-e24.
    • Eur J Drug Metab Pharmacokinet, 1982. 7(3): p. 191-6.
    • L√§kartidningen, 2009. 106(8): p. 516.
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