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Publisher: Portland Press
Journal: Biochemical Society Transactions
Languages: English
Types: Article
Subjects: 23, 47, autophagy, Parkinson's disease, Review Articles, Review Article, 38, leucine-rich repeat kinase, neurodegeneration

Classified by OpenAIRE into

mesheuropmc: nervous system diseases
A wide variety of different functions and an impressive array of interactors have been associated with leucine-rich repeat kinase 2 (LRRK2) over the years. Here, I discuss the hypothesis that LRRK2 may be capable of interacting with different proteins at different times and places, therefore, controlling a plethora of diverse functions based on the different complexes formed. Among these, I will then focus on macroautophagy in the general context of the endolysosomal system. First, the relevance of autophagy in Parkinson's disease will be evaluated giving a brief overview of all the relevant Parkinson's disease genes; then, the association of LRRK2 with macroautophagy and the endolysosomal pathway will be analyzed based on the supporting literature.

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