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Publisher: Springer
Languages: English
Types: Article
Subjects:
PURPOSE\ud Radiotherapy induced xerostomia (RIX) is the most common permanent side effect of radiotherapy (RT) to the head and neck.\ud There is no effective topical treatment. \ud LMS-611 is a mimetic of a natural lamellar body which prevents thick secretions like saliva from congesting organs. \ud Primary objective - assess saliva properties before and during RT to the head and neck. Secondary objectives - re-assess saliva properties with the addition of LMS-611, measure inter-patient variability, correlate patient reported symptoms with laboratory measurements and design subsequent first-in-human clinical trial of LMS-611.\ud METHODS\ud Patients with head and neck cancer receiving RT as primary treatment were recruited. \ud Patients completed the Groningen RIX (GRIX) questionnaire and provided saliva samples at baseline, weeks 2, 4 and 6 of RT. Saliva adhesiveness and viscosity was tested by measuring time taken to travel 5cm down an inclined plane.\ud RESULTS\ud 30 patients were enrolled. \ud The inclined plane test (IPT) results (seconds) were as follows: baseline 31.3, week 2: 49.7, week-4: 51.1, week-6: 55.7. Wide inter-patient variability was seen at baseline. GRIX scores increased as RT progressed. Spearman rank correlation coefficient of inclined plane tests with GRIX scores was -0.06 at baseline, week-2 0.25, week-4 0.12 and week-6 0.08. \ud LMS-611 concentrations of 10mg/ml and 20mg/ml significantly reduced IPT times on saliva samples.\ud CONCLUSIONS\ud Saliva becomes more visco-adhesive and RIX worsens as RT progresses. There is little correlation between objective and subjective measures of RIX. The addition of LMS-611to thick, sticky saliva restores its fluidity ex-vivo. This warrants in-vivo analysis of the effect of LMS-611 upon RIX.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 13. Goldstein DP, Hynds Karnell L, Christensen AJ and Funk GF (2007) Health-related quality of life profiles based on survivorship status for head and neck cancer patients Head Neck 29(3): 221-9
    • 14. Semple C (2001) The role of the CNS in head and neck oncology Nurs Stand 15(23): 39-42
    • 15. Little M, Schipper M, Feng FY et al (2012) Reducing Xerostomia after Chemo-IMRT for Head-and-Neck Cancer: Beyond Sparing the Parotid Glands Int J Radiation Oncol Biol Phys, Vol. 83, No. 3, 1007-1014
    • 16. Vissink A, Mitchell JB, Baum BJ et al, (2010) Clinical management of salivary gland hypofunction and xerostomia in head-and neck cancer patients: Successes and barriers Int. J. Radiation Oncology Biol. Phys., Vol. 78, No. 4, 983-991
    • 17. Gregoire V, Coche E, Cosnard G, Hamoir M, Reychler H. (2000) Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience. Radiother Oncol; 56 (2): 135-50
    • 18. Beetz I, Burlage FR, Henk P et al (2010) The Groningen Radiotherapy-Induced Xerostomia Questionnaire: Development and Validation of a new Questionnaire Radiotherapy & Oncology 97; 127-131
    • 19. R Core Team (2013). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL http://www.R-project.org/ Accessed September 2014
    • 20. DA Freitas, AD Caballero, MM Pereira et al (2011) Oral sequalae of head and neck radiotherapy CEFAC, vol 13 (6); 1103-1108
    • 21. L Franzen, U Funeg rd, T Ericson, R Henriksson (1992) Parotid Gland Function During and Following Radiotherapy of Malignancies in the Head and Neck: A consecutive study of salivary flow and patient discomfort Eur J Cancer, 28 (2-3); 457-462,
    • 22. Dreizen S, Daly TE, Drane JB, Brown LR (1977) Oral complications of cancer radiotherapy Postgrad Med, 61 (2), 85-92
    • 23. Wescott WB, Mira JG, Starcke EN, Shannon IL, Thornby JI (1978) Alterations in whole saliva flow rate induced by fractionated radiotherapy Am J Roentgenol 130 (1), 145-149.
    • 24. Shannon IL, Trodahl JN, Starcke EN (1978) Radio sensitivity of the human parotid gland Proc Soc Exp Biol Med, 157 (1), 50-53
    • 25. JG Mira, WB Wescott, EN Starcke, IL Shannon (1981)Some factors influencing salivary function when treating with radiotherapy Int J Radiat Oncol Biol Phys, 7 (4), 535-541
    • 26. AWT Konings, RP Coppes, A Vissink (2005) On the mechanism of salivary gland radio sensitivity Int. J. Radiation Oncology Biol. Phys., Vol. 62, No. 4, 1187-1194,
    • 27. Porter S, Scully C, Hegarty AM (2004) An update of the etiology and management of xerostomia Oral medicine, oral surgery, oral pathology Vol. 97 No. 1: 28-46
    • 28. Villa A, Abati S* (2011) Risk factors and symptoms associated with xerostomia: a crosssectional study Australian Dental Journal; 56: 290-295
    • 29. Thomson WM (2015) Dry mouth and older people Australian Dental Journal; 60:(1 Suppl): 54-63
    • 30. Zuabi O, Machtei EE, Ben Aryeh H et al (1999) The effect of smoking and periodontal treatment on salivary composition in patients with established periodontitis. J Periodontal.70:1240-6
    • 31. Kolte AP, Kolte RA, Laddha RK (2012) Effect of smoking on salivary composition and periodontal status Indian Soc Periodontol. Jul-Sep; 16(3): 350-353.
    • 32. https://clinicaltrials.gov/ct2/show/NCT02123511?term=GRIX&rank=1https:// clinicaltrials.gov/ct2/show/NCT01823445?term=GRIX&rank=2ogy Biol. Phys., Accessed October 2014
    • 33. MS Tiwana, MK Mahajan, B Uppal, G Koshy , J Sachdeva, HN Lee, SD Talole (2011) Whole saliva physico-biochemical changes and quality of life in head and neck cancer patients following conventional radiation therapy: a prospective longitudinal study Indian journal of cancer, 48(3), 289-295
    • 34. Meirovitz A, Murdoch-Kinch CA, Schipper M, C Pan, A Eisbruch (2006) Grading xerostomia by physicians or by patients after intensitymodulated radiotherapy of head-and-neck cancer. Int J Radiat Oncol Biol Phys 66(2):445-453.
    • 35. TL Lovelace, NF Fox, AJ Sood et al (2014) Management of radiotherapy-induced salivary hypofunction and consequent xerostomia in patients with oral or head and neck cancer: metaanalysis and literature review Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117(5); 595- 607
    • 36. G Chaushu, M Bercovici, S Dori, A Waller, S Taicher, J Kronenberg, YP Talmi (2000) Salivary flow and its relation with oral symptoms in terminally ill patients Cancer, 88(5) 984-7
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