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Rubenwolf, Peter C.; Thomas, Christian; Denzinger, Stefan; Hartmann, Arndt; Burger, Maximilian; Georgopoulos, Nikolaos T.; Otto, Wolfgang (2015)
Publisher: Springer
Languages: English
Types: Article
Subjects: Q1, QD
Purpose\ud Urothelial carcinoma has recently been shown to express several aquaporins (AQP), with AQP3 being of particular interest as its expression is reduced or lost in tumours of higher grade and stage. Loss of AQP3 expression was associated with worse progression-free survival (PFS) in patients with pT1 bladder cancer. The objective of this study was to investigate the prognostic value of AQP3 expression in patients with muscle-invasive bladder carcinoma (MIBC).\ud Methods\ud Retrospective single-centre analysis of the oncological outcome of patients following radical cystectomy (Cx) due to MIBC. Immunohistochemistry was used to assess AQP3 protein expression in 100 Cx specimens. Expression levels of AQP3 were related to clinicopathological variables. The impact of biomarker expression on progression-free, cancer-specific and overall survival was determined by multivariate Cox regression analysis (MVA).\ud Results\ud High expression of AQP3 by the tumour was associated with a statistically significantly improved PFS (75 vs. 19 %, p = 0.043) and CSS (75 vs. 18 %, p = 0.030) and, alongside lymph node involvement, was an independent predictor of PFS (HR 2.871, CI 1.066–7.733, p = 0.037), CSS (HR 3.325, CI 1.204–8.774, p = 0.019) and OS (HR 2.001, CI 1.014–3.947) in MVA.\ud Conclusions\ud Although the results of the study would be strengthened by a larger, more appropriately powered, prospective, multi-institutional study, our findings strongly suggest that AQP3 expression status may represent an independent predictor of PFS and CSS in MIBC and may help select patients in need for (neo-)adjuvant chemotherapy.
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    • 6.  Otto, W., Rubenwolf, P. C., Burger, M. et al.: Loss of aquaporin 3 protein expression  constitutes  an  independent  prognostic  factor  for  progression‐free  survival:  an  immunohistochemical study on stage pT1 urothelial bladder cancer. BMC Cancer, 12: 459  7.  Cheng,  L.,  Davison,  D.  D.,  Adams,  J.  et  al.:  Biomarkers  in  bladder  cancer:  Translational and clinical implications. Crit Rev Oncol Hematol, 89: 73  8.  Frantzi,  M.,  Makridakis,  M.,  Vlahou,  A.:  Biomarkers  for  bladder  cancer  aggressiveness. Curr Opin Urol, 22: 390  9.  Hautmann,  R.  E.,  de  Petriconi,  R.  C.,  Pfeiffer,  C.  et  al.:  Radical  cystectomy  for  urothelial  carcinoma  of  the  bladder  without  neoadjuvant  or  adjuvant  therapy:  long‐term  results in 1100 patients. Eur Urol, 61: 1039  12.  Huang,  Y.,  Zhu,  Z.,  Sun,  M.  et  al.:  Critical  role  of  aquaporin‐3  in  the  human  epidermal  growth  factor‐induced  migration  and  proliferation  in  the  human  gastric  adenocarcinoma cells. Cancer Biol Ther, 9: 1000  13.  Jablonski,  E.  M.,  Mattocks,  M.  A.,  Sokolov,  E.  et  al.:  Decreased  aquaporin  expression leads  to increased resistance to apoptosis in hepatocellular carcinoma. Cancer  Lett, 250: 36, 2007 
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