Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Soutter, Francesca; Kennedy, Lorna J.; Ollier, William E.R.; Solano-Gallego, Laia; Catchpole, Brian (2015)
Publisher: Balliere Tindall
Journal: Veterinary Journal (London, England : 1997)
Languages: English
Types: Article
Subjects: veterinary(all), Beagle, Animal Science and Zoology, Major histocompatibility complex, Short Communication, Dog leucocyte antigen
Beagles are commonly used in vaccine trials as part of the regulatory approval process. Genetic restriction within this breed and the impact this might have on vaccine responses are rarely considered. This study was designed to characterise diversity of dog leucocyte antigen (DLA) class II genes in a breeding colony of laboratory Beagles, whose offspring are used in vaccine studies. DLA haplotypes were determined by PCR and sequence-based typing from genomic DNA extracted from blood. Breeding colony Beagles had significantly different DLA haplotype frequencies in comparison with pet Beagles and both groups showed limited DLA diversity. Restricted DLA class II genetic variability within Beagles might result in selective antigen presentation and vaccine responses that are not necessarily representative of those seen in other dog breeds.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • Calboli, F.C., Sampson, J., Fretwell, N., Balding, D.J., 2008. Population structure and inbreeding from pedigree analysis of purebred dogs. Genetics 179, 593-601.
    • Carrington, M., Nelson, G.W., Martin, M.P., Kissner, T., Vlahov, D., Goedert, J.J., Kaslow, R., Buchbinder, S., Hoots, K., O'Brien, S.J., 1999. HLA and HIV-1: Heterozygote advantage and B*35-Cw*04 disadvantage. Science 283, 1748-1752.
    • Kennedy, L.J., Barnes, A., Happ, G.M., Quinnell, R.J., Bennett, D., Angles, J.M., Day, M.J., Carmichael, N., Innes, J.F., Isherwood, D., et al., 2002a. Extensive interbreed, but minimal intrabreed, variation of DLA class II alleles and haplotypes in dogs. Tissue Antigens 59, 194-204.
    • Kennedy, L.J., Barnes, A., Happ, G.M., Quinnell, R.J., Courtenay, O., Carter, S.D., Ollier, W.E., Thomson, W., 2002b. Evidence for extensive DLA polymorphism in different dog populations. Tissue Antigens 60, 43-52.
    • Kennedy, L.J., Barnes, A., Short, A., Brown, J.J., Lester, S., Seddon, J., Fleeman, L., Francino, O., Brkljacic, M., Knyazev, S., et al., 2007a. Canine DLA diversity: 1. New alleles and haplotypes. Tissue Antigens 69 (Suppl. 1), 272-288.
    • Kennedy, L.J., Lunt, M., Barnes, A., McElhinney, L., Fooks, A.R., Baxter, D.N., Ollier, W.E., 2007b. Factors influencing the antibody response of dogs vaccinated against rabies. Vaccine 25, 8500-8507.
    • Lindblad-Toh, K., Wade, C.M., Mikkelsen, T.S., Karlsson, E.K., Jaffe, D.B., Kamal, M., Clamp, M., Chang, J.L., Kulbokas, E.J., 3rd, Lander, E.S., 2005. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438, 803-819.
    • Thursz, M.R., Thomas, H.C., Greenwood, B.M., Hill, A.V., 1997. Heterozygote advantage for HLA class-II type in hepatitis B virus infection. Nature Genetics 17, 11-12.
    • Wagner, J.L., 2003. Molecular organisation of the canine major histocompatibility complex. The Journal of Heredity 94, 23-26.
  • No related research data.
  • No similar publications.

Share - Bookmark

Funded by projects

Cite this article