LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Estrada, K.; Styrkarsdottir, U; E; Evangelou; Hsu, Y.H.; Duncan, E. L.; Ntzani, E. E.; Oei, L.; Albagha, O.M.; Amin, N.; Kemp, J.P.; Koller, D.L.; Li, G.; Liu, C. T.; Minster, R.L.; Moayyeri, A.; Vandenput, L; Willner, D.; Xiao, S. M.; Yerges-Armstrong, L.M.; Zheng, H.F.; ALONSO, N.; J. Eriksson; Kammerer, C.M.; Kaptoge, S. K.; Leo, P.J.; Thorleifsson, G.; Wilson, S. G.; Wilson, J. F.; Aalto, V.; Alen, M. (Markku) ... view all 181 authors View less authors (2012)
Publisher: Nature Publishing Group
Languages: English
Types: Article
Subjects:
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.

Share - Bookmark

Cite this article