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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Languages: English
Types: Doctoral thesis
Subjects: RG, QP

Classified by OpenAIRE into

mesheuropmc: nutritional and metabolic diseases
T2DM is a growing health problem worldwide. It is now increasingly being diagnosed\ud earlier in life. The factors involved in such an epidemic are complex. The intrauterine\ud environment has long been known as an important contributor to many diseases\ud including metabolic disorders such as T2DM. Recently, there is emerging evidence for\ud maternal micronutrients affecting vital developmental processes in utero which can\ud adversely “programme” the offspring to develop metabolic disorders in later life. Thus,\ud “gene-diet” interaction during foetal development is likely to be a significant\ud contributor to the epidemic of T2DM. In particular, the intrauterine imbalance between\ud the two related vitamins, vitamin B12 and folate, affect DNA methylation and in turn\ud programme the foetus for the whole life. Evidence from mandatory folic acid\ud fortification studies suggests that in the presence of adequate folate, neural tube defects\ud due to vitamin B12 insufficiency have tripled. In India, children born to mothers with\ud “high folate and low vitamin B12” had higher adiposity and insulin resistance.\ud Therefore, micronutrient status during pregnancy is likely to have a significant impact\ud on the metabolic risk of the offspring. This thesis examines whether vitamin B12\ud insufficiency is prevalent in pregnancy, especially in a non-vegetarian population across\ud the world as well as the Saudi pregnant population. As estimated intake is an accepted\ud measure for micronutrient levels, we also examined the relationship between estimated\ud vitamin B12 and folate intake with actual levels in the blood. We have found that\ud vitamin B12 insufficiency was not uncommon during pregnancy across the world even\ud in the non-vegetarian population and is also common in the Saudi population.\ud Surprisingly, vitamin B12 insufficiency was observed in 50% of the tested population\ud even in the presence of adequate vitamin B12 intake. In addition, we have also shown\ud for the first time in the Saudi population that maternal BMI is inversely related to vitamin B12 levels, particularly in pregnancy. Even though we have shown a similar (or\ud worse) picture in mothers with gestational diabetes, this study needs to be replicated, as\ud our numbers are too small. Prospective studies linking the role of vitamin B12\ud insufficiency especially in the presence of high folate on birth outcomes in the Saudi\ud population as well as intervention studies investigating the role of vitamin B12\ud supplementation in women of childbearing age and in pregnancy are urgently needed.
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    • Allen, L. H., J. L. Rosado, et al. (1995). Vitamin B12 deficiency and malabsorption are highly prevalent in rural Mexican communities. Am J Clin Nutr. 62(5): 1013-1019.
    • ADA (2010). Diagnosis and classification of diabetes mellitus. Diabetes Care 33(Suppl.1): S62-S69.
    • ADA (2011). Diagnosis 34(Suppl. 1): S62-S68.
    • Andersson, A., B. Hultberg, et al. (1992). Decreased serum homocysteine in pregnancy. Eur J Clin Chem Clin Biochem. 30(6): 377-379.
    • Andres, E., N. H. Loukili, et al. (2004). Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 171: 251-259.
    • Ardawi, M. S. M., H. A. Nasrat, et al. (2000). Screening for gestational diabetes mellitus in pregnant females. Saudi Med J. 21(2): 155-160.
    • Ardawi, M. S. M., A. A. Rouzi, et al. (2002). Influence of age, sex, folate and vitamin B12 status on plasma homocysteine in Saudis. Saudi Med J. 23(8): 959-968.
    • Areekul, S., K. Ukoskit, et al. (1976). Prevalence of anaemia in pregnant Thai women. J Med Assoc Thai. 59(12): 525-531.
    • Ariens, M., W. Van Mechelen, et al. (2000). Physical risk factors for neck pain. Scand J Work Environ Health 26(1): 7-19.
    • Aubard, Y., N. Darodes, et al. (2000). Hyperhomocysteinemia and pregnancy--review of our present understanding and therapeutic implications. Eur J Obstet Gynecol Reprod Biol. 93(2): 157-165.
    • Baer, H., R. Blum, et al. (2005). Use of a food frequency questionnaire in American Indian and Caucasian pregnant women: a validation study. BMC Public Health 5(1): 135-146.
    • Baik, H. and R. Russell (1999). Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 19(1): 357-377.
    • Bailey, L. B. (2000). New standard for dietary folate intake in pregnant women. Am J Clin Nutr. 71(5): S1304-S1307.
    • Bailey, L. B. (2004). Folate and vitamin B12 recommended intakes and status in the United States. Nutr Rev. 62: S14-S20.
    • Bailey, L. B. and J. F. Gregory (1999). Folate metabolism and requirements. J Nutr. 129(4): 779-782.
    • Baker, H., B. DeAngelis, et al. (2002). Vitamin profile of 563 gravidas during trimesters of pregnancy. J Am Coll Nutr. 21(1): 33-37.
    • Baker, H., O. Frank, et al. (1975). Vitamin profile of 174 mothers and newborns at parturition. Am J Clin Nutr. 28(1): 59-65.
    • Ball, E. W. and C. Giles (1964). Folic acid and vitamin B12 levels in pregnancy and their relation to megaloblastic anaemia. J Clin Pathol. 17(2): 165-174.
    • Ball, G. (1998). Vitamin B12. In: Bioavailability and analysis of vitamins in foods. London: Chapman & Hall, (pp.497-515).
    • Ball, G. F. M. (2004a). Folate. In: Vitamins: their role in the human body. London, UK: Blackwell science,(pp.347-377).
    • Ball, G. F. M. (2004b). Vitamin B12. In: Vitamins: their role in the human body. London, UK: Blackwell Science,(pp.383-392).
    • Barbosa, P. R., S. P. Stabler, et al. (2008). Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women. European J Clin Nutr. 62(8): 1010-1021.
    • Barker, D. J. P. (1995). Intrauterine programming of adult disease. Mol Med Today. 1(9): 418-423.
    • Barker, D. J. P. (2004). The developmental origins of adult disease. J Am Coll Nutr. 23(Suppl. 6): S588-S595.
    • Bazzano, L. A., K. Reynolds, et al. (2006). Effect of folic acid supplementation on risk of cardiovascular diseases. JAMA 296(22): 2720-2726.
    • Bellamy, L., J. P. Casas, et al. (2009). Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 373(9677): 1773-1779.
    • Bender, D. A. (2003). Folate and other pterins and vitamin B12. In: Nutritional biochemistry of the vitamins. Cambridge, UK: Cambridge Univ Press, (pp.270- 323).
    • Bhargava, S. K., H. S. Sachdev, et al. (2004). Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. New Engl J Med. 350(9): 865-875.
    • Bhate, V., S. Deshpande, et al. (2008). Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children. Food Nutr Bull. 29(4): 249- 254.
    • Bingham, S. A. and J. H. Cummings (1985). Urine nitrogen as an independent validatory measure of dietary intake: a study of nitrogen balance in individuals consuming their normal diet. Am J Clin Nutr. 42(6): 1276-1289.
    • Bjorke, A. L. A., P. M. Ueland, et al. (2001). Determinants of cobalamin status in newborns. Pediatrics 108(3): 624-630.
    • Black, A. K., L. H. Allen, et al. (1994). Iron, vitamin B12 and folate status in Mexico: associated factors in men and women and during pregnancy and lactation. J Nutr. 124(8): 1179-1188.
    • Black, M. M. (2008). Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull. 29(Suppl. 1): 126-131.
    • Block, G. and A. M. Hartman (1989). Issues in reproducibility and validity of dietary studies. Am J Clin Nutr. 50(5): 1133-1138.
    • Block, G., A. M. Hartman, et al. (1986). A data-based approach to diet questionnaire design and testing. Am J Epidemiol. 124(3): 453-469.
    • Block, G., A. M. Hartman, et al. (1990). A reduced dietary questionnaire: development and validation. Epidemiology 1(1): 58-64.
    • Blount, B. C., M. M. Mack, et al. (1997). Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci. 94(7): 3290-3295.
    • Bolton-Smith, C., C. Casey, et al. (1991). Antioxidant vitamin intakes assessed using a food-frequency questionnaire: correlation with biochemical status in smokers and non-smokers. Br J Nutr. 65(3): 337-346.
    • Bondevik, G. T., J. Schneede, et al. (2001). Homocysteine and methylmalonic acid levels in pregnant Nepali women. Should cobalamin supplementation be considered? Eur J Clin Nutr. 55(10): 856-864.
    • Bor, M. V., E. Nexo, et al. (2004). Holo-transcobalamin concentration and transcobalamin saturation reflect recent vitamin B12 absorption better than does serum vitamin B12. Clin Chem. 50(6): 1043-1049.
    • Brabin, B., H. van den Berg, et al. (1986). Folacin, cobalamin, and hematological status during pregnancy in rural Kenya: the influence of parity, gestation, and Plasmodium falciparum malaria. Am J Clin Nutr. 43(5): 803-815.
    • Brantsaeter, A. L., M. Haugen, et al. (2007). Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa). Ann Nutr Metab. 51(2): 146-154.
    • Broadfield, E., T. McKeever, et al. (2007). Measuring dietary fatty acid intake: validation of a food-frequency questionnaire against 7d weighed records. Br J Nutr. 90(01): 215-220.
    • Bruinse, H. W. and H. Van den Berg (1995). Changes of some vitamin levels during and after normal pregnancy. Eur J Obstet Gynecol Reprod Biol. 61(1): 31-37.
    • Butterworth, C. and T. Tamura (1989). Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 50(2): 353-358.
    • Buzzard, M. (1998). 24-hour dietary recall and food record methods. In: Nutritional epidemiology. W. Willett New york: Oxford University Press, (pp.50-73).
    • Carmel, R. (2000). Current concepts in cobalamin deficiency. Ann Rev Med. 51(1): 357-375.
    • Carmel, R. (2008). Efficacy and safety of fortification and supplementation with vitamin B12: biochemical and physiological effects. Food Nutr Bull. 29(Suppl. 1): 177-187.
    • Carmel, R. (2009). Does high folic acid intake affect unrecognized cobalamin deficiency, and how will we know it if we see it? Am J Clin Nutr. 90(6): 1449- 1450.
    • Carmel, R. and D. S. Karnaze (1985). The deoxyuridine suppression test identifies subtle cobalamin deficiency in patients without typical megaloblastic anemia. JAMA 253(9): 1284.
    • Carretti, N., G. A. Eremita, et al. (1994). Pattern of vitamin B12 and folic acid during pregnancy. Gynecol Obstet Invest. 38(2): 78-81.
    • Catalano, P. M., L. Presley, et al. (2009). Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care 32(6): 1076-1080.
    • Center for Disease Control and Prevention. (2008). Trends in wheat-flour fortification with folic acid and iron - Worldwide, 2004 and 2007 MMWRMorbidity and Mortality Weekly Report Retrieved 12 August, 2011, from http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5701a4.htm.
    • Choumenkovitch, S. F., J. Selhub, et al. (2002). Folic acid intake from fortification in United States exceeds predictions. J Nutr. 132(9): 2792-2798.
    • Chu, S. Y., W. M. Callaghan, et al. (2007). Maternal obesity and risk of gestational diabetes mellitus. Diabetes Care 30(8): 2070-2076.
    • Church, S. (2006). The history of food composition databases. Nutr Bull. 31(1): 15-20.
    • Clarke, R., P. Sherliker, et al. (2008). Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK. Br J Nutr. 100(05): 1054-1059.
    • Cole, J. K., R. J. Kimber, et al. (1974). Serum folic acid levels and pregnancy in South Australia. A study of the factors associated with low serum folic acid levels with particular reference to racial groups and lactation. Med J Aust. 1(12): 421-424.
    • Colman, N., E. A. Barker, et al. (1975). Prevention of folate deficiency by food fortification. IV. Identification of target groups in addition to pregnant women in an adult rural population. Am J Clin Nutr. 28(5): 471-476.
    • Cook, J. D., J. Alvarado, et al. (1971). Nutritional deficiencey and anemia in Latin America: A collaborative study. Blood 38(5): 591-603.
    • Coustan, D. R. (2000). Making the diagnosis of gestational diabetes mellitus. Clin Obstet Gynecol. 43(1): 99-105.
    • Cuskelly, G. J., H. McNulty, et al. (1996). Effect of increasing dietary folate on redcell folate: implications for prevention of neural tube defects. Lancet 347(9002): 657-659.
    • Dabelea, D. (2007). The predisposition to obesity and diabetes in offspring of diabetic mothers. Diabetes Care 30(Suppl. 2): 169-174.
    • Dabelea D, H. R., PH. Bennett , et al. (1998). Increasing prevalence of type II diabetes in American Indian children. Diabetologia 41(8): 904-910.
    • Dabelea, D., J. Snell-Bergeon, et al. (2005). Increasing prevalence of gestational diabetes mellitus (GDM) over time and by birth cohort - Kaiser permanente of Colorado GDM screening program. Diabetes Care 28(3): 579-584.
    • Dali-Youcef, N. and E. Andrès (2009). An update on cobalamin deficiency in adults. QJM. 102(1): 17-28.
    • De Wals, P., F. Tairou, et al. (2007). Reduction in neural-tube defects after folic acid fortification in Canada. New Engl J Med. 357(2): 135-142.
    • Diamant, M., E. Blaak, et al. (2011). Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes? Obesity Rev. 12(4): 272-281.
    • Diez-Ewald, M. and R. A. Molina (1972). Iron and folic acid deficiency during pregnancy in Western Venezuela. Am J Trop Med Hyg. 21(5): 587-591.
    • Doscherholmen, A., J. McMahon, et al. (1978). Vitamin B12 assimilation from chicken meat. Am J Clin Nutr. 31(5): 825-830.
    • Elhadd, T. A., A. A. Al-Amoudi, et al. (2007). Epidemiology, clinical and complications profile of diabetes in Saudi Arabia: A review. Ann Saudi Med. 27(4): 241-250.
    • Fenech, M. (2001). The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat Res Fund Mol Mech Mut. 475(1-2): 57-67.
    • Fenech, M. (2002). Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs). Food Chem Toxicol. 40(8): 1113- 1117.
    • Fenech, M., C. Aitken, et al. (1998). Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis 19(7): 1163.
    • Fenech, M. and L. R. Ferguson (2001). Vitamins/minerals and genomic stability in humans. Mutat Res Fund Mol Mech Mut. 475(1-2): 1-6.
    • Fernández-Bañares, F., H. Monzón, et al. (2009). A short review of malabsorption and anemia. World J Gastroentero. 15(37): 4644.
    • Food Safety Authority of Ireland (2006). Report of the national committee on folic acid food fortification. Dublin. Retreived 15 September, 2011, from http://www.fsai.ie/uploadedFiles/folic_acid.pdf
    • Ganji, V. and M. R. Kafai (2006). Trends in serum folate, RBC folate, and circulating total homocysteine concentrations in the United States: analysis of data from National Health and Nutrition Examination Surveys, 1988-1994, 1999-2000, and 2001-2002. J Nutr. 136(1): 153-158.
    • Garcia-Casal, M., C. Osorio, et al. (2005). High prevalence of folic acid and vitamin B12 deficiencies in infants, children, adolescents and pregnant women in Venezuela. Eur J Clin Nutr. 59(9): 1064-1070.
    • Garcia, V., R. J. Rona, et al. (2003). Effect of the choice of food composition table on nutrient estimates: a comparison between the British and American (Chilean) tables. Public Health Nutr. 7(04): 577-583.
    • Gibson, R. S., Y. Abebe, et al. (2008). Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern Ethiopia. J Nutr. 138(3): 581-586.
    • Giugliani, E. R., S. M. Jorge, et al. (1984). Folate and vitamin B12 deficiency among parturients from Porto Alegre, Brazil. Rev Invest Clin 36(2): 133-136.
    • Glew, R. H., D. M. McCarthy, et al. (2006). Vitamin B12 deficiency: Is it underestimated in pregnant women? Acta Obstet Gyn Scan. 85(2): 241-242.
    • Godfrey, K. M. and D. J. Barker (2000). Foetal nutrition and adult disease. Am J Clin Nutr. 71(5; SUPPl. 1): 1344-1352.
    • Goedhart, G., M. F. M. van, et al. (2011). Maternal vitamin B-12 and folate status during pregnancy and excessive infant crying. Early Hum Dev. 87(4): 309-314.
    • Goldberg, G. R. and A. E. Black (1998). Assessment of the validity of reported energy intakes-review and recent developments. Food Nutr Res. 42(0): 6-9.
    • Goldberg, G. R., A. E. Black, et al. (1991). Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-recording. Eur J Clin Nutr. 45(12): 569-581.
    • Goldenberg, R. L., T. Tamura, et al. (1992). Serum folate and foetal growth retardation: a matter of compliance? Obstet Gynecol. 79(5): 719-722.
    • Green R (2009). Is it time for vitamin B-12 fortifications? What are the questions? Am J Clin Nutr. 89(suppl): S712-S716.
    • Green, T. J., O. B. Allen, et al. (1998). A three-day weighed food record and a semiquantitative food-frequency questionnaire are valid measures for assessing the folate and vitamin B12 intakes of women aged 16 to 19 years. J Nutr. 128(10): 1665-1671.
    • Guerra-Shinohara, E. M., O. E. Morita, et al. (2004). Low ratio of Sadenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newborns. Am J Clin Nutr. 80(5): 1312-1322.
    • Gunarathne, A., J. Patel, et al. (2008). Increased 5 year mortality in the migrant South Asian stroke patients with diabetes mellitus in the United Kingdom: The West Birmingham Stroke Project. Int J Clin Pract. 62(2): 197-201.
    • Guven, M. A., M. Kilinc, et al. (2006). Elevated second trimester serum homocysteine levels in women with gestational diabetes mellitus. Arch Gynecol Obstet. 274(6): 333-337.
    • Hales, C. N. and D. J. P. Barker (1992). Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35(7): 595-601.
    • Hales, C. N. and D. J. P. Barker (2001). The thrifty phenotype hypothesis. Br Med Bull. 60(1): 5-20.
    • Haliloglu, B., F. B. Aksungar, et al. (2010). Negative correlation between D-dimer and homocysteine levels during pregnancy and the postpartum period: a prospective study. Eur J Obstet Gynecol Reprod Biol. 153(1): 23-26.
    • Hall, M., M. Gamble, et al. (2007). Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs. Environ Health Perspect. 115(10): 1503.
    • Harrington, K. E., P. J. Robson, et al. (2008). The North/South Ireland food consumption survey: survey design and methodology. Public Health Nutr. 4(5a): 1037-1042.
    • Harris, M. I., R. Klein, et al. (1992). Onset of NIDDM occurs at least 4-7 yr before clinical diagnosis. Diabetes Care 15(7): 815-819.
    • Harrison, G. G., O. M. Galal, et al. (2000). Underreporting of food intake by dietary recall is not universal: a comparison of data from Egyptian and American women. J Nutr. 130(8): 2049-2054.
    • Hassan, S. M., D. Fakhry, et al. (2008). Relationship between Homocysteine Level and Gestational Diabetes. J Appl Sci Res. 4(12): 2169-2174.
    • Hattersley, A. T. and J. E. Tooke (1999). The foetal insulin hypothesis: an alternative explanation of the association of low bir thweight with diabetes and vascular disease. Lancet 353(9166): 1789-1792.
    • Hay, G., T. Clausen, et al. (2010). Maternal folate and cobalamin status predicts vitamin status in newborns and 6-month-old infants. J Nutr. 140(3): 557-564.
    • Herbert, V. (1987). Recommended dietary intakes (RDI) of vitamin B12 in humans. Am J Clin Nutr. 45(4): 671-678.
    • Herbig, K., E. P. Chiang, et al. (2002). Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and Sadenosylmethionine biosyntheses. J Biol Chem. 277(41): 38381-38389.
    • Heyssel, R., R. BOZAN, et al. (1966). Vitamin B12 Turnover in Man: The Assimulation of Vitamin B12 from Natural Foodstuff by Man and Estimates of Minimal Daily Dietary Requirements. Am J Clin Nutr. 18(3): 176-184.
    • Hill, R. J. and P. S. W. Davies (2001). The validity of self-reported energy intake as determined using the doubly labelled water technique. Br J Nutr. 85(04): 415- 430.
    • Hill, T. R., M. M. O'Brien, et al. (2004). Vitamin D intakes in 18-64-y-old Irish adults. Eur J Clin Nutr. 58(11): 1509-1517.
    • Hinderaker, S. G., B. E. Olsen, et al. (2002). Anemia in pregnancy in rural Tanzania: associations with micronutrients status and infections. Eur J Clin Nutr. 56(3): 192-199.
    • Ho, C. H., C. C. Yuan, et al. (1987). Serum ferritin, folate and cobalamin levels and their correlation with anemia in normal full-term pregnant women. Eur J Obstet Gynecol Reprod Biol. 26(1): 7-13.
    • Hogeveen, M., H. J. Blom, et al. (2010). Maternal homocysteine and related B vitamins as risk factors for low birthweight. Am J Obstet Gynecol. 202(6): 572. e1-6.
    • Jacques, P. F., J. Selhub, et al. (1999). The effect of folic acid fortification on plasma folate and total homocysteine concentrations. New Engl J Med. 340(19): 1449- 1454.
    • Jiang, T., P. Christian, et al. (2005). Micronutrient deficiencies in early pregnancy are common, concurrent, and vary by season among rural Nepali pregnant women. J Nutr. 135(5): 1106-1112.
    • Jimenez-Moleon, J. J., A. Bueno-Cavanillas, et al. (2000). Predictive value of a screen for gestational diabetes mellitus: influence of associated risk factors. Acta Obstet Gynecol Scand. 79(11): 991-998.
    • Johansson, G., A. Wikman, et al. (2001). Underreporting of energy intake in repeated 24-hour recalls related to gender, age, weight status, day of interview, educational level, reported food intake, smoking habits and area of living. Public Health Nutr. 4(4): 919-927.
    • Jones, K. M., M. Ramirez-Zea, et al. (2007). Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet. J Nutr. 137(5): 1307-1313.
    • Jovanovic, L. and D. J. Pettitt (2001). Gestational diabetes mellitus. JAMA 286(20): 2516-2518.
    • Kaaks, R. (1997). Biochemical markers as additional measurements in studies of the accuracy of dietary questionnaire measurements: conceptual issues. Am J Clin Nutr. 65(4): S1232-S1239.
    • Kabagambe, E. K., A. Baylin, et al. (2001). Application of the method of triads to evaluate the performance of food frequency questionnaires and biomarkers as indicators of long-term dietary intake. Am J Epidemiol. 154(12): 1126-1135.
    • Kafatos, A. G., I. G. Vlachonikolis, et al. (1989). Nutrition during pregnancy: the effects of an educational intervention program in Greece. Am J Clin Nutr. 50(5): 970-979.
    • Kamen, B. (1997). Folate and antifolate pharmacology. Semin Oncol. 24(Suppl. 18): 30-39.
    • Kang, S. S., P. W. K. Wong, et al. (1986). Total homocyst(e)ine in plasma and amniotic fluid of pregnant women. Metabolism 35(10): 889-891.
    • Katre, P., D. Bhat, et al. (2010). Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate status. Asia Pac J Clin Nutr. 19(3): 335-343.
    • Khan, M. A. and M. A. Al-Kanhal (1998). Dietary energy and protein requirements for Saudi Arabia: a methodological approach. East Mediterr Health J. 4: 68-75.
    • Kimmons, J. E., H. M. Blanck, et al. (2006). Associations between body mass index and the prevalence of low micronutrient levels among US adults. MedGenMed 8(4): 59.
    • Kjos SL, B. T. (1999). Gestational diabetes mellitus. N Engl J Med. 341(23): 1749- 1756.
    • Knight, E. M., B. G. Spurlock, et al. (1991). Hematologic and vitamin status of African American women and their relationships to pregnancy outcome. Nutr Res. 11(12): 1357-1375.
    • Koc, A., A. Kocyigit, et al. (2006). High frequency of maternal vitamin B12 deficiency as an important cause of infantile vitamin B12 deficiency in Sanliurfa province of Turkey. Eur J Nutr. 45(5): 291-297.
    • Koebnick, C., U. A. Heins, et al. (2002). Longitudinal concentrations of vitamin B12 and vitamin B12-binding proteins during uncomplicated pregnancy. Clin Chem. 48(6): 928-933.
    • Krishnaveni, G. V., J. C. Hill, et al. (2009). Low plasma vitamin B 12 in pregnancy is associated with gestational 'diabesity'and later diabetes. Diab5et2o(l1o1g)i:a 2350-2358.
    • Kuzminski, A. M., E. J. Del Giacco, et al. (1998). Effective treatment of cobalamin deficiency with oral cobalamin. Blood 92(4): 1191-1198.
    • Larsen, N., F. K. Vogensen, et al. (2010). Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 5(2): e9085.
    • Leader, A., K. H. Wong, et al. (1981). Maternal nutrition in pregnancy. Part I: a review. Can Med Assoc J. 125(6): 545-549.
    • Levine, A. and A. Doscherholmen (1983). Vitamin B12 bioavailability from egg yolk and egg white: relationship to binding proteins. Am J Clin Nutr. 38(3): 436-439.
    • Levy Marchal, C. and D. Jaquet (2004). Long term metabolic consequences of being born small for gestational age. Pediatr Diabetes 5(3): 147-153.
    • Li, L., E. C. Ekstrom, et al. (2008). Nutritional status has marginal influence on the metabolism of inorganic arsenic in pregnant Bangladeshi women. Environ Health Perspect. 116(3): 315-321.
    • Lillycrop, K. A., E. S. Phillips, et al. (2005). Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 135(6): 1382-1386.
    • Lindstrom, E., M. B. Hossain, et al. (2011). Prevalence of anemia and micronutrient deficiencies in early pregnancy in rural Bangladesh, the MINIMat trial. Acta Obstet Gynecol Scand 90(1): 47-56.
    • Lowenstein, L., M. Lalonde, et al. (1960). Vitamin B12 in pregnancy and the puerperium. Am J Clin Nutr. 8(3): 265.
    • Lumley, J., L. Watson, et al. (2002). Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects (Review). The Cochrane Collaboration: John Wiley & Sons, Lt .
    • Macdiarmid, J. and J. Blundell (1998). Assessing dietary intake: who, what and why of under-reporting. Nutr Res Rev. 11(02): 231-253.
    • Mathews, F., P. Yudkin, et al. (1999). Influence of maternal nutrition on outcome of pregnancy: prospective cohort study. BMJ 319(7206): 339-343.
    • Matthews, J. (1995). Cobalamin and folate deficiency in the elderly. Baillière Clin Haem. 8(3): 679-697.
    • McCance, D. R., D. J. Pettitt, et al. (1994). Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? BMJ 308(6934): 942-945.
    • McCance, R. A., Widdowson, E.M., Holland, B. (1991). McCane and Widdowson's: the composition of foods : London:HMSO.
    • Mcmillen, I. C. and J. S. Robinson (2005). Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev. 85(2): 571- 633.
    • Monsen, A. L. B., P. M. Ueland, et al. (2001). Determinants of cobalamin status in newborns. Pediatrics 108(3): 624-630.
    • Morris, M. S., P. F. Jacques, et al. (2007). Folate and vitamin B12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr. 85(1): 193-200.
    • Mouratidou, T., F. Ford, et al. (2006). Validation of a food-frequency questionnaire for use in pregnancy. Public Health Nutrition 9(4): 515-522.
    • Murphy, M. M., A. M. Molloy, et al. (2007). Longitudinal study of the effect of pregnancy on maternal and foetal cobalamin status in healthy women and their offspring. J Nutr. 137(8): 1863-1867.
    • Murphy, M. M., J. M. Scott, et al. (2002). The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study. Am J Clin Nutr. 76(3): 614-619.
    • Musaiger, A. O. (2002). Diet and prevention of coronary heart disease in the Arab Middle East countries. Med Princ Pract. 11(2): 9-16.
    • Musaiger, A. O. (2004). Overweight and obesity in the Eastern Mediterranean Region: can we control it. East Mediterr Health J. 10(6): 789-793.
    • Muthayya, S. (2009). Maternal nutrition & low birth weight-what is really important? Indian J Med Res 130: 600-608.
    • Muthayya, S., P. Dwarkanath, et al. (2006a). The relationship of neonatal serum vitamin B12 status with birth weight. Asia Pac J Clin Nutr. 15(4): 538-543.
    • Muthayya, S., A. Kurpad, et al. (2006b). Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians. Eur J Clin Nutr. 60(6): 791-801.
    • Oh, R. C. and D. L. Brown (2003). Vitamin B12 Deficiency. Am Fam Physician 67(5): 979-996.
    • Ortiz-Andrellucchi, A., J. Doreste-Alonso, et al. (2009). Dietary assessment methods for micronutrient intake in pregnant women: a systematic review. Br J Nutr. 102(S1): S64-S86.
    • Osifo, B. and A. Onifade (1976). Maternal and foetal vitamin B12 concentration at parturition among Nigerians. Trop Geogr Med. 28(1): 37-40.
    • Pagán, K., J. Hou, et al. (2002). Mid-pregnancy serum homocysteine and B-vitamin concentrations and foetal growth. Nutr Res. 22(10): 1133-1141.
    • Pardo, J., Y. Peled, et al. (2000). Evaluation of low serum vitamin B12 in the nonanemic pregnant women. Hum Reprod. 15: 224-226.
    • Park, H., Y. J. Kim, et al. (2004). The Risk of Folate and Vitamin B12 Deficiencies Associated with Hyperhomocysteinemia among Pregnant Women. Am J Perinatol. 21(8): 469-476.
    • Ray, J. G. and H. J. Blom (2003). Vitamin B12 insufficiency and the risk of foetal neural tube defects. QJM. 96(4): 289-295.
    • Ray, J. G., P. R. Wyatt, et al. (2007). Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population. Epidemiology 18(3): 362-366.
    • Refsum, H. (2001). Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome. Br J Nutr. 85(S2): 109-113.
    • Relton, C. L., M. S. Pearce, et al. (2005). The influence of erythrocyte folate and serum vitamin B12 status on birth weight. Br J Nutr. 93(5): 593-600.
    • Roberts, P. D., H. James, et al. (1973). Vitamin B 12 status in pregnancy among immigrants to Britain. British Medical Journal 3(5871): 67-72.
    • Scholl, T. O., M. Hediger, et al. (1996). Dietary and serum folate: their influence on the outcome of pregnancy. Am J Clin Nutr. 63(4): 520-525.
    • Scholl, T. O. and W. G. Johnson (2000). Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr. 71(5): S1295-S1303.
    • Schulpis, K., A. Spiropoulos, et al. (2004). Maternal-neonatal folate and vitamin B12 serum concentrations in Greeks and in Albanian immigrants. J Hum Nutr Diet. 17(5): 443-448.
    • Tooth, L., R. Ware, et al. (2005). Quality of reporting of observational longitudinal research. Am J Epidemiol. 161(3): 280.
    • Ubbink, J. B., W. Vermaak, et al. (1994). Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr. 124(10): 1927.
    • Ueland, P. M., H. Refsum, et al. (1993). Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem. 39(9): 1764-1933.
    • Ueland, P. M. and S. E. Vollset (2004). Homocysteine and folate in pregnancy. Clin Chem. 50(8): 1293-1295.
    • Ulrich, C. M. (2008). Folate and cancer prevention-where to next? Counterpoint. Cancer Epidemiol Biomarkers Prev. 17(9): 2226-2230.
    • van der Windt, D. A. W. M., E. Thomas, et al. (2000). Occupational risk factors for shoulder pain: a systematic review. J Occup Environ Med. 57(7): 433-442.
    • Willett, W. C. (1994). Future directions in the development of food-frequency questionnaires. Am J Clin Nutr. 59(1): S171-S174.
    • Willett, W. C., L. Sampson, et al. (1985). Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol. 122(1): 51.
    • Willett, W. C., M. J. Stampfer, et al. (1983). Vitamins A, E, and carotene: effects of supplementation on their plasma levels. Am J Clin Nutr. 38(4): 559.
    • Yajnik, C. S. and J. S. Yudkin (2004). The Y-Y paradox. Lancet. 363: 163.
    • Yang, Q., L. D. Botto, et al. (2006). Improvement in stroke mortality in Canada and the US, 1990 to 2002. Circulation 113(10): 1335-1343.
    • Yusufji, D., V. I. Mathan, et al. (1973). Iron, folate, and vitamin B12 nutrition in pregnancy: a study of 1 000 women from southern India. Bull W.H.O. 48(1): 15-22.
    • Zachau-Christiansen, Z. A. C., H. O. F. Hoff-Jorgensen, et al. (1962). The relative haemoglobin, iron, vitamin B12 and folic acid values in the blood of mothers and their newborn infants. Dan Med Bull. 9: 157-166.
    • Zhou, J. and R. C. Austin (2009). Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms. Biofactors 35(2): 120-129.
    • Zimmet, P. (1999). Diabetes epidemiology as a tool to trigger diabetes research and care. Diabetologia 42(5): 499-518.
    • Zimmet, P., K. Alberti, et al. (2001). Global and societal implications of the diabetes epidemic. Nature 414(6865): 782-787.
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