OpenAIRE is about to release its new face with lots of new content and services.
During September, you may notice downtime in services, while some functionalities (e.g. user registration, login, validation, claiming) will be temporarily disabled.
We apologize for the inconvenience, please stay tuned!
For further information please contact helpdesk[at]

fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Adebisi, Adeola O.; Conway, Barbara R (2011)
Publisher: Informa Healthcare
Languages: English
Types: Article
Subjects: Q1, QD
Many strategies have been proposed to explore the possibility of exploiting gastroretention for drug delivery. Such systems would be useful for local delivery, for drugs that are poorly soluble at higher pH or primarily absorbed from the proximal small intestine. Generally, the requirements of such strategies are that the vehicle maintains controlled drug release and exhibits prolonged residence time in the stomach. Despite widespread reporting of technologies, many have an inherent drawback of variability in transit times. Microparticulate systems, capable of distributing widely through the gastrointestinal tract, can potentially minimise this variation. While being retained in the stomach, the drug content is released slowly at a desired rate, resulting in reduced fluctuations in drug levels. This review summarises the promising role of microencapsulation in this field, exploring both floating and mucoadhesive microparticles and their application in the treatment of Helicobacter pylori, highlighting the clinical potential of eradication of this widespread infection
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • ADEBISI, A. O. & CONWAY, B. R. 2010. Development of gastro-retentive systems for the eradication of H-pylori infections in the treatment of peptic ulcer. ABSTRACTS FROM THE UK-PHARMSCI CONFERENCE, 1-3 SEPTEMBER 2010. Journal of Pharmacy and Pharmacology, , 62, 1201- 1516.
    • AHMED, M. G., SATISH, K. B. P. & KIRAN, K. B. P. 2010. Formulation and evaluation of gastricmucoadhesive drug delivery systems of captopril. Journal of Current Pharmaceutical Research, 2, 26-32.
    • AKBUGA, J. 1993. Use of chitosonium malate as a matrix in sustained-release tablets. International Journal of Pharmaceutics, 89, 19-24.
    • AKIYAMA, Y., NAGAHARA, N., KASHIHARA, T., HIRAI, S. & TOGUCHI, H. 1995. In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acid esters of fatty acids and a poly(acrylic acid) derivatives. Pharm. Res., 12, 397-405.
    • ANILKUMAR, S. J. 2008. Gastro retentive Drug Delivery Systems: An Overview. [Online], 6. [Accessed 12 October 2010].
    • ANNESE, V., BASSOTTI, G., NAPOLITANO, G., FRUSCIANTE, V., BRUNO, M., CONOSCITORE, P., GERMANI, U., MORELLI, A. & ANDRIULLI, A. 1995. Gastric emptying of solids in patients with nonobstructive Crohn's disease is sometimes delayed. J Clin Gastroenterol., 21, 279-82.
    • ASHWELL, G. & HARFORD, J. 1982. Carbohydrate-specific receptors of the liver. Annu. Rev. Biochem, 51, 531-554.
    • ASPDEN, T. J., ILLUM, L. & SKAUGRUD, O. 1996. Chitosan as a nasal delivery system-evaluation of insulin absorption enhancement and effect on nasal memebrane integrity using rat models Eur. J. Pharm. Sci., 4, 23-31.
    • ATYABI, F., SHARMA, H. L., MOHAMMAD, H. A. H. & FELL, J. T. 1996a. Controlled drug release from coated floating ion exchange resin beads. Journal of Controlled Release, 42, 25-28.
    • ATYABI, F., SHARMA, H. L., MOHAMMAD, H. A. H. & FELL, J. T. 1996b. In vivo evaluation of a novel gastric retentive formulation based on ion exchange resins. Journal of Controlled Release, 42, 105-113.
    • BATCHELOR, H., CONWAY, B. & WILLIAMS, R. O. 2007. Targeting the infections within the gastrointestinal tract. In: R.O., I. W., TAFT D.R & J.T., M. (eds.) Advanced drug formulation design to optimize therapeutic outcomes (Drugs and the Pharmaceutical Sciences) New York:: Informa Healthcare.
    • BECHGAARD, H. & LADEFOGED, K. 1978. Distribution of pellets in the gastrointestinal tract. The influence on transit time exerted by the density or diameter of pellets. J Pharm Pharmacol, 30, 690-2.
    • BENITA, S., BENOIT, J. P., PUISIEUX, F. & THIES, C. 1984. Characterization of drug-loaded poly(d,llactide) microspheres. J Pharm Sci, 73, 1721-4.
    • BERNKOP-SCHNÜRCH, A., GABOR, F., SZOSTAK, M. P. & LUBITZ, W. 1995. An adhesive drug delivery system based on K99-fimbriae. European Journal of Pharmaceutical Sciences, 3, 293-299.
    • BHASKARA, R. S. & SHARMA, C. P. 1997. Use of chitosan as biomaterial:studies on its safety and hemostatic potential. J . Biomed. Mater. Res., 34, 21-28.
    • BODMEIER, R. & MCGINITY, J. W. 1987a. Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique. I. Methods and morphology. J Microencapsul, 4, 279-88.
    • BODMEIER, R. & MCGINITY, J. W. 1987b. Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique. II. Some process parameters influencing the preparation and properties of microspheres. J Microencapsul, 4, 289-97.
    • DESHPANDE, A. A., RHODES, C. T., SHAH, N. H. & MALICK, A. W. 1996. Controlled-Release Drug Delivery Systems for Prolonged Gastric Residence : An Overview. Drug Development and Industrial Pharmacy., 22, 531-539.
    • DHALIWAL, S., JAIN, S., SINGH, H. P. & TIWARY, A. K. 2008. Mucoadhesive microspheres for gastroretentive delivery of acyclovir: in vitro and in vivo evaluation. AAPS J, 10, 322-30.
    • DUBEY, R. & PARIKH, R. 2004. Two-stage optimization process for formulation of chitosan microspheres. AAPS PharmSciTech, 5, 20-28.
    • EL-GIBALY, I. 2002. Development and in vitro evaluation of novel floating chitosan microcapsules for oral use: comparison with non-floating chitosan microspheres. Int J Pharm, 249, 7-21.
    • ERNI, W. & HELD, K. 1987. The hydrodynamically balanced system: a novel principle of controlled drug release. Eur Neurol, 27 Suppl 1, 21-7.
    • FABREGAS, J. L., CLARAMUNT, J., CUCALA, J., POUS, R. & SILES, A. 1994. “In-Vitro” Testing of an Antacid Formulation with Prolonged Gastric Residence Time (Almagate Flot-Coat®). Drug Development and Industrial Pharmacy, 20, 1199-1212.
    • FELL, J. T. & DIGENIS, G. A. 1984. Imaging and behaviour of solid oral dosage forms in vivo. International Journal of Pharmaceutics, 22, 1-15.
    • FIEBRIG, I., HARDING, S. E., ROWE, A. J., HYMAN, S. C. & DAVIS, S. S. 1995. Transmission electron microscopy studies on pig gastric mucin and its interactions with chitosan. Carbohydrate Polymers, 28, 239-244.
    • FIX, J. A., CARGILL, R. & ENGLE, K. 1993. Controlled gastric emptying. III. Gastric residence time of a nondisintegrating geometric shape in human volunteers. Pharm Res, 10, 1087-9.
    • FRANZ, M. R. & OTH, M. P. 1992. Sustained release: Bilayer buoyant dosage form. US patent application US Patent 5232704. August 3,1992.
    • GABA , P. 2008. Floating Microspheres: A review. [Online], 6. Available:
    • GABOR, F., WIRTH, M., JURKOVICH, B., HABERL, I., THEYER, G., WALCHER, G. & HAMILTON, G. 1997. Lectin-mediated bioadhesion: Pro-teolytic stability and binding-characteristics of wheat germagglu-tinin and Solanum tuberosumlectin on Caco-2, HT-29 and human colonocytes.
    • . J. Control. Rel., 49, 27-37.
    • GAD, S. C. 2008. Pharmaceutical Manufacturing Handbook. In: GAD, S. C. (ed.) Production and Processes. New York: Wiley Interscience.
    • GAO, Y., CUI, F., GUAN, Y., YANG, L., WANG, Y. & ZHANG, L. 2006. Preparation of roxithromycinpolymeric microspheres by the emulsion solvent diffusion method for taste masking. Int. J. Pharm, 318, 62-69.
    • GARG, R. & GUPTA, G. D. 2008. Progress in controlled gastroretentive delivery systems Tropical Journal of Pharmaceutical Research, 7, 1055-1066.
    • GARG, R. & GUPTA, G. D. 2010. Gastroretentive Floating Microspheres of Silymarin: Preparation and In Vitro Evaluation. Tropical Journal of Pharmaceutical Research, 9, 59-66.
    • GARG, S. & SHARMA, S. 2003. Gastroretentive drug delivery systems. Business Briefing. Pharmatech [Online].
    • GÅSERØD, O., JOLLIFFE, I. G., HAMPSON, F. C., DETTMAR, P. W. & SKJÅK-BRÆK, G. 1998. The enhancement of the bioadhesive properties of calcium alginate gel beads by coating with chitosan. International Journal of Pharmaceutics, 175, 237-246.
    • GATTANI, S. G., SAVALIYA, P. J. & BELGAMWAR, V. S. 2010. Floating-mucoadhesive beads of clarithromycin for the treatment of Helicobacter pylori infection. Chem Pharm Bull (Tokyo). 58, 782-7.
    • GIBLEY, I. E. 2002. Development and in vitro evaluation of novel floating chitosan microcapsule for oral use: comparison with nonfloating chitosan microspheres. Int J Pharm, 249, 7-21.
    • GOHEL, M. C. & AMIN, A. F. 1998. Formulation optimization of controlled release diclofenac sodium microspheres using factorial design. J Control Release, 51, 115-22. 52
    • Drugs, 145, 15-28.
    • GRILL, B. B., LANGE, R., MARKOWITZ, R., HILLEMEIER, A. C., MCCALLUM, R. W. & GRYBOSKI, J. D. 1985. Delayed gastric emptying in children with Crohn's disease. J Clin Gastroenterol., 7, 216- 26.
    • GRONING, R., CLOER, C., GEORGARAKIS, M. & MULLER, R. S. 2007. Compressed collagen sponges as gastroretentive dosage forms: in vitro and in vivo studies. Eur J Pharm Sci, 30, 1-6.
    • GRÖNING, R. & HEUN, G. 1984. Oral Dosage Forms with Controlled Gastrointestinal Transit. Drug Development and Industrial Pharmacy, 10, 527-539.
    • GRUBER, P., RUBENSTEIN, A., LI, V. H., BASS, P. & ROBINSON, J. R. 1987. Gatric emtying of nondigestible solids in the fasted dog. Journal of Pharmaceutical Sciences., 76, 117-122.
    • GU, T. H., CHEN, S. X., ZHU, J. B., SONG, D. J., GUO, J. Z. & HOU, H. M. 1992. [Pharmacokinetics and pharmacodynamics of diltiazem floating tablets]. Zhongguo Yao Li Xue Bao, 13, 527-31.
    • GUPTA, P. K. & HUNG, C. T. 1989. Albumin microspheres. II: Applications in drug delivery. J Microencapsul, 6, 463-72.
    • HAAS, J. & LEHR, C. M. 2002. Developments in the area of bioadhesive drug delivery systems. Expert Opin Biol Ther., 2, 287-98.
    • HARI, P. R., CHANDY, T. & SHARMA, C. P. 1996. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. J Microencapsul, 13, 319-29.
    • HARRIGAN, R. M. 1977. Drug delivery device for preventing contact of undissolved drug with the stomach lining. . United States patent application. October 25, 1977.
    • HASSAN, E. E., PARISH, R. C. & GALLO, J. M. 1992. Optimized formulation of magnetic chitosan microspheres containing the anticancer agent, oxantrazole. Pharm Res., 9, 390-7.
    • HE, P., DAVIS, S. S. & ILLUM, L. 1998. In vitro evaluation of the mucoadhesive properties of chitosan microspheres. International Journal of Pharmaceutics, 166, 75-88.
    • HENRIKSEN, I., GREEN, K. L., SMART, J. D., SMISTAD, G. & KARLSEN, J. 1996. Bioadhesion of hydrated chitosans: An in vitro and in vivo study. International Journal of Pharmaceutics, 145, 231- 240.
    • HIRTZ, J. 1985. The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation. Br J Clin Pharmacol., 19, 77S-83S.
    • HOROWITZ, M., WISHART, J. M., JONES, K. L. & HEBBARD, G. S. 1996. Gastric emptying in diabetes: an overview. Diabet Med., 13, S16-22.
    • HOU, W. M., MIYAZAKI, S., TAKADA, M. & KOMAI, T. 1985. Sustained release of indomethacin from chitosan granules. Chem Pharm Bull (Tokyo). 33, 3986-92.
    • HUANG, K., LEE, B. P., INGRAM, D. R. & MESSERSMITH, P. B. 2002. Synthesis and characterization of self-assembling block copolymers containing bioadhesive end groups. Biomacromolecules., 3, 397-406.
    • HUNT, J. N. 1968. Regulation of gastric emptying. In: SOCIETY, A. P. (ed.) Handbook of Physiology. Washington DC: American Physiology Society.
    • HWANG, S. J., PARK, H. & PARK, K. 1998. Gastric retentive drug-delivery systems. Crit Rev Ther Drug Carrier Syst, 15, 243-84.
    • IANNUCCELLI, V., COPPI, G., BERNABEI, M. T. & CAMERONI, R. 1998. Air compartment multiple-unit system for prolonged gastric residence. Part I. Formulation study. International Journal of Pharmaceutics, 174, 47-54.
    • ICHIKAWA, M., KATO, T., KAWAHARA, M., WATANABE, S. & KAYANO, M. 1991a. A new multiple-unit oral floating dosage system. II: In vivo evaluation of floating and sustained-release 53
    • MURATA, Y., SASAKI, N., MIYAMOTO, E. & KAWASHIMA, S. 2000. Use of floating alginate gel beads for stomach-specific drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 50, 221-226.
    • NAGAHARA, N., AKIYAMA, Y., NAKAO, M., TADA, M., KITANO, M. & OGAWA, Y. 1998. Mucoadhesive microspheres containing amoxicillin for clearance of Helicobacter pylori. Antimicrob Agents Chemother., 42, 2492-4.
    • NAGAI, T., NISHIMOTO, Y., NAMBU, N., SUZUKI, Y. & SEKINE, K. 1984. Powder dosage form of insulin for nasal administration. J Controlled Release, 1, 15-22.
    • NAISBETT, B. & JOHN, W. 1995. The potential use of tomato lectin for oral drug delivery:3.Bioadhesion in vivo. Int. J. Pharm, 114, 227-236.
    • NAYAK, A. K., MAJI, R. & DAS, B. K. 2010. Gastro retentive drug delivery systems: a review. Journal of Pharmaceutical and Clinical Research, Vol3 Issue 1 January- March 2010 pg 2, 3.
    • NUR, A. O. & ZHANG, J. S. 2000. Captopril floating and/or bioadhesive tablets: design and release kinetics. Drug Dev Ind Pharm., 26, 965-9.
    • OBEIDAT, W., M. & PRICE, J. C. 2006. Preparation and evaluation of Eudragit S 100 microspheres as pH-sensitive release preparations for piroxicam and theophylline using the emulsion-solvent evaporation method. Journal of Microencapsulation, 23, 195-202.
    • OHYA, Y., TAKEI, T., KOBAYASHI, H. & OUCHI, T. 1993. Release behaviour of 5-fluorouracil from chitosan-gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition. J Microencapsul., 10, 1-9.
    • OTH, M., FRANZ, M., TIMMERMANS, J. & MOES, A. 1992. The bilayer floating capsule: a stomachdirected drug delivery system for misoprostol. Pharm Res, 9, 298-302.
    • PARK, H. & ROBINSON, J. R. 1987. Mechanisms of mucoadhesion of poly(acrylic acid) hydrogels. Pharm Res, 4, 457-64.
    • PARK, K. & ROBINSON, J. R. 1984. Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion. International Journal of Pharmaceutics, 19, 107-127.
    • PATEL, G. M. 2007. Floating Drug Delivery System: An innovative approach to prolong gastric retention., 5.
    • PATEL, J. K., BODAR, M. S., AMIN, A. F. & PATEL, M. M. 2004. Formulation and optimization of mucoadhesive microspheres of metoclopramide. Ind. J. Pharm.Sci, 66, 300-305. 56
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article

Cookies make it easier for us to provide you with our services. With the usage of our services you permit us to use cookies.
More information Ok