Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Rizi, K; Green, Rebecca J.; Donaldson, M. X.; Williams, Adrian C. (2011)
Publisher: Springer Verlag
Languages: English
Types: Article
Abstract\ud Purpose: The pH discrepancy between healthy and atopic dermatitis skin was identified as a site specific trigger for delivering hydrocortisone from microcapsules. \ud Methods: Using Eudragit L100, a pH-responsive polymer which dissolves at pH 6, hydrocortisone-loaded microparticles were produced by oil-in-oil microencapsulation or spray drying. Release and permeation of hydrocortisone from microparticles alone or in gels was assessed and preliminary stability data was determined.\ud Results: Drug release from microparticles was pH-dependent though the particles produced by spray drying also gave significant non-pH dependent burst release, resulting from their porous nature or from drug enrichment on the surface of these particles. This pH-responsive release was maintained upon incorporation of the oil-in-oil microparticles into Carbopol- and HPMC-based gel formulations. In-vitro studies showed 4 to 5-fold higher drug permeation through porcine skin from the gels at pH 7 compared to pH 5. \ud Conclusions: Permeation studies showed that the oil-in-oil generated particles deliver essentially no drug at normal (intact) skin pH (5.0 – 5.5) but that delivery can be triggered and targeted to atopic dermatitis skin where the pH is elevated. The incorporation of these microparticles into Carbopol- and HPMC-based aqueous gel formulations demonstrated good stability and pH-responsive permeation into porcine skin.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 19. Jenning V, Gysler A, Schafer-Korting M, Gohla S. Vitamin A loaded solid lipid nanoparticles for topical use:occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm. 2000;49:211-8.
    • 20. Alvarez-Roman R, Naik A, Kalia YN, Guy RH, Fessi H. Skin penetration and distribution of polymeric nanoparticles. J Controlled Release. 2004;99(1):53.
    • 21. Zhao Y, Brown MB, Jones SA. Pharmaceutical foams: are they the answer to the dilemma of topical nanoparticles? Nanomed Nanotechnol Biol Med. 2010;6(2):227-36.
    • 22. Knorr F, Lademann J, Patzelt A, Sterry W, Blume-Peytavi U, Vogt A. Follicular transport route - Research progress and future perspectives. Eur J Pharm Biopharm. 2008;71(2):173-80.
    • 23. Lademann J, Richter H, Teichmann A, Otberg N, Blume-Peytavi U, Luengo J, et al. Nanoparticles - An efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm. 2007;66(2):159.
    • 24. Flynn GL. Comparision between in vivo techniques. Acta Pharm Suce. 1983;20:54-9.
    • 25. Poulsen BJ, Flynn GL. In vitro methods to study dermal delivery and percutaneous absorption. In: Bronaugh RL, Maibach HI, editors. Percutaneous absorption: Mechanism, absorption and drug delivery. New York: Marcel Dekker; 1985. p. 431-59.
    • 26. Salama RO, Traini D, Chan H-K, Young PM. Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. Eur J Pharm Biopharm. 2008;70(1):145-52.
    • 27. British National Formulary. 59 ed: British Medical Association & Royal Pharmaceutical Society of Great Britain; March 2010.
    • 28. Barry BW. Dermatological formulations:percutaneous absorption. 1st ed. New York: Marcel Dekker Inc; 1993.
    • 29. Stankler L. Diseases of the skin. Br Med J. 1974;1:27-9.
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article