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Roth, C.; Petricevic, M.; John, A.; Goddard-Borger, E. D.; Davies, G. J.; Williams, S. J. (2016)
Languages: English
Types: Article
Subjects: 1503, 2504, 2503, 1600, 2508, 2506, 2505

Classified by OpenAIRE into

mesheuropmc: fluids and secretions
Bacteroides vulgatus is a member of the human microbiota whose abundance is increased in patients with Crohn's disease. We show that a B. vulgatus glycoside hydrolase from the carbohydrate active enzyme family GH123, BvGH123, is an N-acetyl-β-galactosaminidase that acts with retention of stereochemistry, and, through a 3-D structure in complex with Gal-thiazoline, provide evidence in support of a neighbouring group participation mechanism.
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    • P. G. Falk, L. V. Hooper, T. Midtvedt and J. I. Gordon, Microbiol. Mol. Biol. Rev., 1998, 62, 1157.
    • D. P. Bojanova and S. R. Bordenstein, PLoS Biol., 2016, 14, e1002503.
    • C. van Lieshout, FEMS Microbiol. Lett., 1989, 58, 37.
    • a) B. A. White, R. Lamed, E. A. Bayer and H. J. Flint, Annu. Rev. Microbiol., 2014, 68, 279; b) N. Terrapon, V.
    • Lombard, H. J. Gilbert and B. Henrissat, Bioinformatics, 2015, 31, 647; c) J. Larsbrink, T. E. Rogers, G. R.
    • Davies, E. C. Martens and H. Brumer, Nature, 2014, 506, 498; d) J. Larsbrink, A. J. Thompson, M. Lundqvist, J.
    • G. Gardner, G. J. Davies and H. Brumer, Mol. Microbiol., 2014, 94, 418; e) G. R. Hemsworth, G. Dejean, G. J.
    • 5 6 7 8 9 10 11 12 13 Davies and H. Brumer, Biochem. Soc. Trans., 2016, 44, 94.
    • Mills and E. C. Martens, mBio, 2015, 6.
    • T. Sumida, K. Fujimoto and M. Ito, J. Biol. Chem., 2011, 286, 14065.
    • Alteen, D. J. Vocadlo and A. B. Boraston, J. Mol. Biol., 2016.
    • D. J. Vocadlo and G. J. Davies, Curr. Opin. Chem. Biol., 2008, 12, 539.
    • S. J. Williams, B. Mark, D. J. Vocadlo, M. N. James and S. G. Withers, J. Biol. Chem., 2002, 277, 40055.
    • Chin and D. J. Vocadlo, J. Biol. Chem., 2005, 280, 25313; b) G. E. Whitworth, M. S. Macauley, K. A. Stubbs, R.
    • Vocadlo, J. Am. Chem. Soc., 2007, 129, 635.
    • R. J. Dennis, E. J. Taylor, M. S. Macauley, K. A. Stubbs, J. P. Turkenburg, S. J. Hart, G. N. Black, D. J. Vocadlo and G. J. Davies, Nat. Struct. Mol. Biol., 2006, 13, 365.
    • Paton and A. B. Boraston, J. Biol. Chem., 2015, 290, 30888.
    • a) E. C. Lai and S. G. Withers, Biochemistry, 1994, 33, 14743; b)S. Drouillard, S. Armand, G. J. Davies, C. E.
    • Vorgias and B. Henrissat, Biochem J, 1997, 328, 945; c) B. L. Mark, D. J. Vocadlo, S. Knapp, B. L. Triggs-Raine, S. G. Withers and M. N. G. James, J. Biol. Chem., 2001, 276, 10330.
    • S. Knapp and D. S. Myers, J. Org. Chem., 2002, 67, 2995.
    • F. BŠckhed, R. E. Ley, J. L. Sonnenburg, D. A. Peterson and J. I. Gordon, Science, 2005, 307, 1915.
    • E. Krissinel, Nucleic Acids Res., 2015, 43, W314.
    • Y. He, M. S. Macauley, K. A. Stubbs, D. J. Vocadlo and G. J. Davies, J Am Chem Soc, 2010, 132, 1807.
    • Biomol. Chem., 2012, 10, 2607.
    • J. M. Macdonald, C. A. Tarling, E. J. Taylor, R. J. Dennis, D. S. Myers, S. Knapp, G. J. Davies and S. G. Withers, Angew. Chem. Int. Ed., 2010, 49, 2599.
    • Turkenburg, G. J. Davies, K. S. Wilson and E. J. Taylor, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 66, 973.
    • Boraston, J. Biol. Chem., 2009, 284, 11676.
    • J. F. Darby, J. Landstrom, C. Roth, Y. He, G. J. Davies and R. E. Hubbard, Angew Chem Int Ed Engl, 2014, 53, 13419.
    • R. R. Copley and P. Bork, J. Mol. Biol., 2000, 303, 627; ) A. D. Goldman, J. T. Beatty and L. F. Landweber, J.
    • Mol. Evolution, 2016, 82, 17.
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