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Adekanmbi, Isaiah; Tanner, K. Elizabeth; Kubba, Haytham; Lu, Helen (2015)
Languages: English
Types: Other
Subjects: Q1, RF, RJ
Stents provide biological support in body conduits and are useful for counteracting stenosis (constriction) in cardiovascular, gastrointestinal, uretheral and airway passages1. However, the current widespread use of permanent metal stents that remain throughout the lifespan of a patient, threaten restenosis, thrombosis, or physical irritation if not surgically removed.\ud In infants the clinical requirement is for a stent that retains structural integrity for periods of several weeks up to many months in vivo during host tissue restoration2 and from a materials perspective this requires an implant with appropriate mechanical and degradation characteristics. \ud Bioresorbable phosphate glass fibres have shown enormous potential for temporary implants and tissue repair, owing to their mechanical properties and solubility in aqueous media which can be modified by addition of various oxide compounds3,4. Further, when combined with degradable polymers the resulting glass fibre polymer composites (GFRP) become ductile allowing them to be forged into supporting scaffolds with suitable mechanical and dissolution properties. To date however, their use for stenting applications has not been investigated possibly due to major difficulties of processing these compositions into fibre form.\ud In this study, two phosphate glass fibre compositions containing SiO2 (silica) and B2O3 (Boron) were fabricated to test the hypothesis that B2O3 containing phosphate glass fibres present enhanced mechanical and dissolution behaviour for use as a degradable stent.
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