LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Roseanne Rosario; Panagiotis Filis; Victoria Tessyman; Hazel Kinnell; Andrew J Childs; Nicola K Gray; Richard A Anderson
Publisher: Public Library of Science (PLoS)
Journal: PLoS ONE
Languages: English
Types: Article
Subjects: Mouse Models, Protein Translation, Animal Models, Research Article, Meiosis, Ovaries, Anatomy, Reproductive System, Cell Processes, Cytoplasm, Genetics, Chromosome Biology, OVA, Germ Cells, Cellular Types, Biology and Life Sciences, RNA, Oocytes, Research and Analysis Methods, Animal Cells, Medicine, Nucleic acids, Q, R, Cell Biology, Model Organisms, Messenger RNA, Cellular Structures and Organelles, Biochemistry, Science, Medicine and Health Sciences, Gene Expression, Cell Cycle and Cell Division

Classified by OpenAIRE into

mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities, nervous system diseases
Germ cell development and primordial follicle formation during fetal life is critical in establishing the pool of oocytes that subsequently determines the reproductive lifespan of women. Fragile X-associated primary ovarian insufficiency (FXPOI) is caused by inheritance of the FMR1 premutation allele and approximately 20% of women with the premutation allele develop ovarian dysfunction and premature ovarian insufficiency. However, the underlying disease mechanism remains obscure, and a potential role of FMRP in human ovarian development has not been explored. We have characterised the expression of FMR1 and FMRP in the human fetal ovary at the time of germ cell entry into meiosis through to primordial follicle formation. FMRP expression is exclusively in germ cells in the human fetal ovary. Increased FMRP expression in germ cells coincides with the loss of pluripotency-associated protein expression, and entry into meiosis is associated with FMRP granulation. In addition, we have uncovered FMRP association with components of P-bodies and stress granules, suggesting it may have a role in mRNA metabolism at the time of onset of meiosis. Therefore, this data support the hypothesis that FMRP plays a role regulating mRNAs during pivotal maturational processes in fetal germ cells, and ovarian dysfunction resulting from FMR1 premutation may have its origins during these stages of oocyte development.

Share - Bookmark

Cite this article