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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Publisher: American Diabetes Association
Languages: English
Types: Article
Subjects:
Identifiers:doi:10.2337/db15-0021
Obesity is increasing, yet despite the necessity to maintain muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown. Eleven obese (BMI 31.9 ±1.1) and 15 healthy weight (HW; BMI 23.4 ±0.3) older men (55-75 years old) participated in a study that determined muscle protein synthesis (MPS) and leg protein breakdown (LPB) under post-absorptive (hypoinsulinaemic euglycaemic clamp) and post-prandial (hyperinsulinemic hyperaminoacidaemic euglycaemic clamp) conditions. Obesity was associated with systemic inflammation, greater leg fat mass, and patterns of mRNA expression consistent with muscle deconditioning, whilst leg lean mass, strength and work done during maximal exercise were no different. Under post-absorptive conditions, MPS and LPB were equivalent between groups, while insulin and amino acid administration increased MPS in only HW subjects and was associated with lower leg glucose disposal (LGD, 63%) in obese. Blunting of MPS in the obese was offset by an apparent decline in LPB, which was absent in HW subjects. Lower post-prandial LGD in obese subjects and blunting of MPS responses to amino acids suggests obesity in older adults is associated with diminished muscle metabolic quality. However this doesn’t appear to be associated with lower leg lean mass or strength.
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    • Metabolism 1992;41:1028-1034 28. Bruce AC, McNurlan MA, McHardy KC, Broom J, Buchanan KD, Calder AG, Milne E, McGaw BA, Garlick PJ, James WP: Nutrient oxidation patterns and protein metabolism in lean and obese subjects. Int J Obes 1990;14:631-646 29. Stephens FB, Chee C, Wall BT, Murton AJ, Shannon CE, van Loon LJ, Tsintzas K: Lipid induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men. Diabetes 10.2337/db14-0961 30. Breen L, Stokes KA, Churchward-Venne TA, Moore DR, Baker SK, Smith K, Atherton PJ, Phillips SM: Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab 2013;98:2604-2612 31. Sonne MP, Alibegovic AC, Hojbjerre L, Vaag A, Stallknecht B, Dela F: Effect of 10 days of bedrest on metabolic and vascular insulin action: a study in individuals at risk for type 2 diabetes. J Appl Physiol 2010;108:830-837 32. Duvivier BM, Schaper NC, Bremers MA, van Crombrugge G, Menheere PP, Kars M, Savelberg HH: Minimal intensity physical activity (standing and walking) of longer duration improves insulin action and plasma lipids more than shorter periods of moderate to vigorous
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