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Calder, Ewen D.D.; Sharif, Salaheddin A.I.; McGonagle, Fiona I.; Sutherland, Andrew (2015)
Publisher: American Chemical Society
Languages: English
Types: Article
Subjects:
A one-pot multibond-forming process involving a thermally mediated Overman rearrangement and a ring closing metathesis reaction of allylic trichloroacetimidates bearing a 2-allyloxyaryl group has been developed for the synthesis of 5-amino-substituted 2,5-dihydro-1-benzoxepines. Chemoselective reduction and functionalization of these compounds allowed access to a range of pharmacologically active 5-amino-2,3,4,5-tetrahydro-1-benzoxepine scaffolds.
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