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Loomis, A. Katrina; Kabadi, Shaum; Preiss, David; Hyde, Craig; Bonato, Vinicius; St. Louis, Matthew; Desai, Jigar; Gill, Jason M. R.; Welsh, Paul; Waterworth, Dawn; Sattar, Naveed (2015)
Publisher: Endocrine Society
Languages: English
Types: Article
Subjects: Original Articles

Classified by OpenAIRE into

mesheuropmc: nutritional and metabolic diseases, digestive system diseases, digestive system
Context:\ud The relationship between rising body mass index (BMI) and prospective risk of non-alcoholic fatty liver disease (NAFLD) / non-alcoholic steatohepatitis (NASH) is virtually absent.\ud Objective:\ud Determine the extent of the association between BMI and risk of future NAFLD diagnosis, stratifying by sex and diabetes.\ud Design:\ud Two prospective studies using Humedica and THIN with 1.54 and 4.96 years of follow-up respectively.\ud Setting:\ud Electronic health record databases\ud Participants:\ud Patients with had a recorded BMI measurement between 15–60kg/m2, and smoking status, and one year of active status prior to baseline BMI. Patients with a diagnosis or history of chronic diseases were excluded.\ud Interventions:\ud None\ud Main Outcome Measure:\ud Recorded diagnosis of NAFLD/NASH during follow-up (Humedica ICD-9 code 571.8, and read codes for NAFLD and NASH in THIN).\ud Results:\ud Hazard ratios (HR) were calculated across BMI categories using BMI of 20–22.5kg/m2 as the reference category, adjusting for age, sex and smoking status. Risk of recorded NAFLD/NASH increased linearly with BMI and was approximately 5-fold higher in Humedica (HR=4.78, 95% CI 4.17–5.47) and 9-fold higher in THIN (HR=8.93, 7.11–11.23) at a BMI of 30–32.5 kg/m2 rising to around 10-fold higher in Humedica (HR=9.80, 8.49–11.32) and 14-fold higher in THIN (HR=14.32, 11.04–18.57) in the 37.5–40 kg/m2 BMI category. Risk of NAFLD/NASH was approximately 50% higher in men, and approximately double in those with diabetes.\ud Conclusions:\ud These data quantify the consistent and strong relationships between BMI and prospectively recorded diagnoses of NAFLD/NASH and emphasize the importance of weight reduction strategies for prevention and management of NAFLD.

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Funded by projects

  • EC | EMIF

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