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Publisher: Elsevier Ireland Ltd
Languages: English
Types: Article
Subjects:
Objective: The association of the circulating serum vitamin D metabolite 25-hydroxyvitamin D (25OHD) with atherosclerotic burden is unclear, with previous studies reporting disparate results.\ud \ud

Method: Psychological, social and biological determinants of ill health (pSoBid) is a study of participants aged 35–64 years from Glasgow who live at extremes of the socioeconomic spectrum. Vitamin D deficiency was defined as 25OHD < 25nmol/L, as per convention. Cross-sectional associations between circulating 25OHD concentrations and a range of socioeconomic, lifestyle, and biochemistry factors, as well as carotid intima media thickness (cIMT) and plaque presence were assessed in 625 participants.\ud \ud

Results: Geometric mean levels of circulating 25OHD were higher among the least deprived (45.6 nmol/L, 1-SD range 24.4–85.5) versus most deprived (34.2 nmol/L, 1-SD range 16.9–69.2; p < 0.0001). In the least deprived group 15% were “deficient” in circulating 25OHD versus 30.8% in the most deprived (χ2p < 0.0001). Log 25OHD was 27% lower among smokers (p < 0.0001), 20% higher among the physically active versus inactive (p = 0.01), 2% lower per 1 kg/m2 increase in body mass index (BMI) (p < 0.0001), and showed expected seasonal variation (χ2p < 0.0001). Log 25OHD was 13% lower in the most versus least deprived independent of the aforementioned lifestyle confounding factors (p = 0.03). One unit increase in log 25OHD was not associated with atherosclerotic burden in univariable models; cIMT (effect estimate 0.000 mm [95% CI −0.011, 0.012]); plaque presence (OR 0.88 [0.75, 1.03]), or in multivariable models.\ud \ud

Conclusion: There is no strong association of 25OHD with cIMT or plaque presence, despite strong evidence 25OHD associates with lifestyle factors and socioeconomic deprivation.

  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • [11] [12] [13] [14] [15] [16] [17] [18] Velupillai YN, Packard CJ, Batty GD, et al. Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study. BMC Public Health 2008; 8:126.
    • Scottish Government. Scottish Index of Multiple Deprivation 2006: General Report.
    • Edinburgh, 2006. (http://www.scotland.gov.uk/Topics/Statistics/SIMD) [accessed T 25/4/12] P Woodward M, Brindle P, Tunstall-Pedoe H. Adding social deprivation and faImily history to cardiovascular risk assessment: the ASSIGN score from the Scottish HReart Health Extended Cohort (SHHEC). Heart 2007; 93:172-6. C S
    • socioeconomic deprivation: cross sectional, population based study. BMJ 2009; 339:b4170. N A
    • Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study. CirculaDtion 2004; 109:1089-94.
    • Knox S, Harris J, Calton L, Wallace EAM. A simple automated solid-phase extraction procedure for measurement of 25T-hydroxyvitamin D3 and D2 by liquid chromatographytandem mass spectrometry. APnn Clin Biochem 2009; 46:226-30.
    • Targher G, Bertolini L, Padovani R, et al. Serum 25-hydroxyvitamin D3 concentrations C
    • and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol C
    • (Oxf) 2006; 65:593-7.
    • Mehrotra R, Budoff M, Christenson P, et al. Determinants of coronary artery calcification in diabetics with and without nephropathy. Kidney Int 2004; 66:2022-31.
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