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Publisher: Springer Berlin Heidelberg
Journal: Immunogenetics
Languages: English
Types: Article
Subjects: Major histocompatibility complex, Original Article, Texel breed, Class II region, Sheep, Polymorphism
Understanding the structure of the major histocompatibility complex, especially the number and frequency of alleles, loci and haplotypes, is crucial for efficient investigation of the way in which the MHC influences susceptibility to disease. Nematode infection is one of the most important diseases suffered by sheep, and the class II region has been repeatedly associated with differences in susceptibility and resistance to infection. Texel sheep are widely used in many different countries and are relatively resistant to infection. This study determined the number and frequency of MHC class II genes in a small flock of Texel sheep. There were 18 alleles at DRB1, 9 alleles at DQA1, 13 alleles at DQB1, 8 alleles at DQA2 and 16 alleles at DQB2. Several haplotypes had no detectable gene products at DQA1, DQB1 or DQB2, and these were defined as null alleles. Despite the large numbers of alleles, there were only 21 distinct haplotypes in the population. The relatively small number of observed haplotypes will simplify finding disease associations because common haplotypes provide more statistical power but complicate the discrimination of causative mutations from linked marker loci. Electronic supplementary material The online version of this article (doi:10.1007/s00251-016-0962-6) contains supplementary material, which is available to authorized users.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • Atlija M, Gutíerrez-Gil B, Arranz J-J, Semmer J, Stear M, Buitkamp J (2015) Major histocompatibility complex class IIB polymorphism in an ancient Spanish breed. Immunogenetics 67:531-537
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    • Bishop SC, Jackson F, Coop RL, Stear MJ (2004) Genetic parameters for resistance to nematode infections in Texel lambs and their utility in breeding programmes. Anim Sci 78:185-194
    • Dukkipati VSR, Blair HT, Garrick DJ, Murray A (2006) BOvar-MHC^- ovine major histocompatibility complex: role in genetic resistance to diseases. N Z Vet J 54:153-160
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    • Hassan M, Good B, Hanrahan JP, Campion D, Sayers G, Mulcahy G, Sweeney T (2011) The dynamic influence of the DRB1*1101 allele on the resistance of sheep to experimental Teladorsagia circumcincta infection. Vet Res 42:46
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    • Nikbakht G, Rezaii H, Stear MJ, Talebi MA, Mahmoudzadeh H (2012) Allelic polymorphism in the second exon of Ovar-DRB1 in fattailed sheep. Vet J 192:547-549
    • Sayers G, Good B, Hanrahan JP, Ryan M, Angles JM, Sweeney T (2005) Major histocompatibility complex DRB1 gene: its role in nematode resistance in Suffolk and Texel sheep breeds. Parasitology 131:403-409
    • Scott PC, Maddox JF, Gogolin-Ewens KJ, Brandon MR (1992) The nucleotide sequence and evolution of ovine MHC class II B genes: DQB and DRB. Immunogenetics 35:217-217
    • Siva Subramaniam N, Morgan E, Wetherall J, Stear M, Groth D (2015) A comprehensive mapping of the structure and gene organisation in the sheep MHC class I region. BMC Genomics 16:1-17
    • Snibson KJ, Maddox JF, Fabb SA, Brandon MR (1998) Allelic variation of ovine MHC class II DQA1 and DQA2 genes. Anim Genet 29:356-362
    • Stear MJ, Innocent GT, Buitkamp J (2005) The evolution and maintenance of polymorphism in the major histocompatibility complex. Vet Immunol Immunopathol 108:53-57
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    • Wegner KM, Reusch TBH, Kalbe M (2003) Multiple parasites are driving major histocompatibility complex polymorphism in the wild. J Evol Biol 16:224-232
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