LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Publisher: Springer-Verlag
Journal: Diabetologia
Languages: English
Types: Article
Subjects: Abdominal obesity, Obesity, Case–cohort study, Physical activity, Article, Incident diabetes
Aims/hypothesis We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. Methods The InterAct case–cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were stratified according to physical activity level, BMI and WC. Results A one-category difference in physical activity (equivalent to approximately 460 and 365 kJ/day in men and women, respectively) was independently associated with a 13% (HR 0.87, 95% CI 0.80, 0.94) and 7% (HR 0.93, 95% CI 0.89, 0.98) relative reduction in the risk of type 2 diabetes in men and women, respectively. Lower levels of physical activity were associated with an increased risk of diabetes across all strata of BMI. Comparing inactive with active individuals, the HRs were 1.44 (95% CI 1.11, 1.87) and 1.38 (95% CI 1.17, 1.62) in abdominally lean and obese inactive men, respectively, and 1.57 (95% CI 1.19, 2.07) and 1.19 (95% CI 1.01, 1.39) in abdominally lean and obese inactive women, respectively. Conclusions/interpretation Physical activity is associated with a reduction in the risk of developing type 2 diabetes across BMI categories in men and women, as well as in abdominally lean and obese men and women. Electronic supplementary material The online version of this article (doi:10.1007/s00125-012-2532-2) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Colditz GA, Willett WC, Stampfer MJ et al (1990) Weight as a risk factor for clinical diabetes in women. Am J Epidemiol 132:501-513
    • 2. Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC (1994) Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 17:961-969
    • 3. Folsom AR, Kushi LH, Hong CP (2000) Physical activity and incident diabetes mellitus in postmenopausal women. Am J Public Health 90:134-138
    • 4. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr (1991) Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 325:147-152
    • 5. Manson JE, Rimm EB, Stampfer MJ et al (1991) Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338:774-778
    • 6. Hu FB, Sigal RJ, Rich-Edwards JW et al (1999) Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. JAMA 282:1433-1439
    • 7. Weinstein AR, Sesso HD, Lee IM et al (2004) Relationship of physical activity vs body mass index with type 2 diabetes in women. JAMA 292:1188-1194
    • 8. Siegel LC, Sesso HD, Bowman TS, Lee IM, Manson JE, Gaziano JM (2009) Physical activity, body mass index and diabetes risk in men: a prospective study. Am J Med 122:1115-1121
    • 9. Hu G, Lindström J, Valle TT et al (2004) Physical activity, body mass index and risk of type 2 diabetes in patients with normal or impaired glucose regulation. Arch Int Med 164:892-896
    • 10. Rana JS, Li TY, Manson JE, Hu FB (2007) Adiposity compared with physical inactivity and risk of type 2 diabetes in women. Diabetes Care 30:53-58
    • 11. Wang Y, Rimm EB, Stampfer MJ, Willett WC, Hu FB (2005) Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr 81:555-563
    • 12. Pischon T, Boeing H, Hoffmann K et al (2008) General and abdominal adiposity and risk of death in Europe. N Engl J Med 359:2105-2120
    • 13. Jeon CY, Lokken RP, Hu FB, van Dam RM (2007) Physical activity of moderate intensity and risk of type 2 diabetes: a systematic review. Diabetes Care 30:744-752
    • 14. The InterAct Consortium (2011) Design and cohort description of the InterAct project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. Diabetologia 54:2272-2282
    • 15. Haftenberger M, Lahmann PH, Panico S et al (2002) Overweight, obesity and fat distribution in 50- to 64-year-old participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutr 5:1147-1162
    • 16. Alberti KG, Zimmet P, Shaw J (2006) Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 23:469-480
    • 17. The InterAct consortium (2012) Validity of a short questionnaire to assess physical activity in 10 European countries (EPIC-InterAct Study). Eur J Epidemiol 27:15-25. doi:10.1007/s10654-011-9625-y
    • 18. Brage S, Brage N, Franks PW et al (2004) Branched equation modelling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure. J Appl Physiol 96:343-351
    • 19. Brage S, Ekelund U, Brage N et al (2007) Hierarchy of individual calibration levels for heart rate and accelerometry to measure physical activity. J Appl Physiol 103:682-692
    • 20. Slimani N, Deharveng G, Unwin I et al (2007) The EPIC nutrient database project (ENDB): a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC Study. Eur J Clin Nutr 61:1037-1056
    • 21. Holloszy JO (2005) Exercise-induced increase in muscle insulin sensitivity. J Appl Physiol 99:338-345
    • 22. Shojaee-Moradie F, Baynes KC, Pentecost C et al (2007) Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism. Diabetologia 50:404-413
    • 23. Williams P (2007) Changes in vigorous physical activity and incident diabetes in male runners. Diabetes Care 30:2838-2842
    • 24. Tuomilehto J, Lindström J, Eriksson JG, Finnish Diabetes Prevention Study Group et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343-1350
    • 25. Knowler WC, Barrett-Connor E, Fowler SE, Diabetes Prevention Program Research Group et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403
  • No related research data.
  • Discovered through pilot similarity algorithms. Send us your feedback.

Share - Bookmark

Cite this article