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Yaqoob, Parveen (1998)
Publisher: Associação Brasileira de Divulgação Científica
Languages: English
Types: Article
Subjects: lipids, fatty acids, adhesion molecules, R5-920, Medicine (General), olive oil, immunity, Biology (General), QH301-705.5
Animal studies suggest that olive oil is capable of modulating functions of cells of the immune system in a manner similar to, albeit weaker than, fish oils. There is some evidence that the effects of olive oil on immune function in animal studies are due to oleic acid rather than to trace elements or antioxidants. Importantly, several studies have demonstrated effects of oleic acid-containing diets on in vivo immune responses. In contrast, consumption of a monounsaturated fatty acid (MUFA)-rich diet by humans does not appear to bring about a general suppression of immune cell functions. The effects of this diet in humans are limited to decreasing aspects of adhesion of peripheral blood mononuclear cells, although there are trends towards decreases in natural killer cell activity and proliferation. The lack of a clear effect of MUFA in humans may be attributable to the higher level of monounsaturated fat used in the animal studies, although it is ultimately of importance to examine the effects of intakes which are in no way extreme. The effects of MUFA on adhesion molecules are potentially important, since these molecules appear to have a role in the pathology of a number of diseases involving the immune system. This area clearly deserves further exploration.
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    • 1. Nestle M (1995). Mediterranean diets: historical and research overview. American Journal of Clinical Nutrition, 61 (Suppl): 1313S-1320S.
    • 2. Keys A (1970). Coronary heart disease in seven countries. Circulation , 41: 1-211.
    • 3. Mensink RP & Katan MB (1987). Effect of monounsaturated fatty acids versus complex carbohydrates on high-density lipoproteins in healthy men and women. Lancet, i: 122-124.
    • 4. Mata P, Alvarez-Silva LA, Rubio MJ, Nuno J & De Oya M (1992). Effects of long-term monounsaturated vs polyunsaturated-enriched diets on lipoproteins in healthy men and women. American Journal of Clinical Nutrition, 55: 846-850.
    • 5. Virella G, Fourspring K, Hyman B, HaskillStroud R, Long L, Virella I, La Via M, Gross AJ & Lopes-Virella M (1991). Immunosuppressive effects of fish oil in normal human volunteers: correlation with the in vitro effects of eicosapentaenoic acid on human lymphocytes. Clinical Immunology and Immunopathology, 61: 161-176.
    • 6. Cleland LG, French JK, Betts WH, Murphy GA & Elliot MJ (1988). Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis. Journal of Rheumatology, 15: 1471-1475.
    • 7. Dehmer GJ, Popma JJ, van den Berg EK, Eichhorn EJ, Prewitt JB, Campbell WB, Jennings L, Willerson JT & Schmitz JM (1988). Reduction in the rate of early restenosis after coronary angioplasty by a diet supplemented with n-3 fatty acids. New England Journal of Medicine, 319: 733-740.
    • 8. Milner MR (1989). Fish oil for preventing coronary restenosis. Lancet, II: 693.
    • 9. Kremer JM, Lawrence DA, Jubiz W, DiGiacomo R, Rynes R, Bartholomew LE & Sherman M (1990). Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Arthritis and Rheumatism, 33: 810-820.
    • 10. Linos A, Kaklamanis E, Kontomerkos A, Koumantaki Y, Gazi S, Vaiopoulos G, Tsokos GC & Kaklamanis PH (1991). The effect of olive oil and fish consumption on rheumatoid arthritis - a case control study. Scandinavian Journal of Rheumatology, 20: 419-426.
    • 11. Yaqoob P & Calder PC (1993). The effects of fatty acids on lymphocyte functions. International Journal of Biochemistry, 25: 1705-1714.
    • 12. Gurr MI (1983). The role of lipids in the regulation of the immune system. Progress in Lipid Research, 22: 257-287.
    • 13. Yaqoob P, Newsholme EA & Calder PC (1994). The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation. Immunology, 82: 603-610.
    • 14. Yaqoob P, Newsholme EA & Calder PC (1995). The effect of fatty acids on leukocytes subsets and proliferation in whole blood. Nutrition Research, 15: 279-287.
    • 15. Yaqoob P, Newsholme EA & Calder PC (1995). Influence of cell culture conditions on diet-induced changes in lymphocyte fatty acid composition. Biochimica et Biophysica Acta , 1255: 333-340.
    • 16. Berger A, German JB, Chiang BL, Ansari AA, Keen CL, Fletcher MP & Gershwin MR (1993). Influence of feeding unsaturated fats on growth and immune status of mice. Journal of Nutrition, 123: 225-233.
    • 17. Gunstone FD, Harwood JL & Padley FB (1994). The Lipid Handbook. 2nd edn. Chapman & Hall, London, 79-82.
    • 18. Jeffery NM, Yaqoob P, Newsholme EA & Calder PC (1996). The effects of olive oil upon rat serum lipid levels and lymphocyte functions are due to oleic acid. Annals of Nutrition and Metabolism, 40: 71- 80.
    • 19. Jeffery NM, Cortina M, Newsholme EA & Calder PC (1997). Effects of variations in the proportions of saturated, monounsaturated and polyunsaturated fatty acids in the rat diet on spleen lymphocyte functions. British Journal of Nutrition, 77: 805- 823.
    • 20. Yaqoob P, Knapper JA, Webb DH, Williams CM, Newsholme EA & Calder PC (1998). The effect of olive oil consumption on immune functions in middle-aged men. American Journal of Clinical Nutrition (in press).
    • 21. Ferro-Luzzi A & Branca F (1995). The Mediterranean diet, Italian style: prototype of a healthy diet. American Journal of Clinical Nutrition, 61 (Suppl): 1338S1345S.
    • 22. Herberman RB (1988). Lymphocytes: Cytotoxic activities. In: Gallin JI, Goldstein IM & Snyderman R (Editors), Inflammation: Basic Principles and Clinical Correlates. Raven Press, New York, 613-630.
    • 23. Yaqoob P, Newsholme EA & Calder PC (1994). Inhibition of natural killer cell activity by dietary lipids. Immunology Letters, 41: 241-247.
    • 24. Munro JM (1993). Endothelial-leukocyte adhesive interactions in inflammatory diseases. European Heart Journal, 14 (Suppl K): 72-77.
    • 25. De Caterina R, Cybulsky MI, Clinton SK, Gimbrone Jr MA & Libby P (1994). The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arteriosclerosis and Thrombosis, 14: 1829-1836.
    • 26. Sanderson P, Yaqoob P & Calder PC (1995). Effects of dietary lipid manipulation upon rat spleen lymphocyte functions and the expression of lymphocyte surface molecules. Journal of Nutritional and Environmental Medicine, 5: 119-132.
    • 27. Chapman PT & Haskard DO (1995). Leukocyte adhesion molecules. British Medical Bulletin, 51: 296-311.
    • 28. Languino LR, Duperray A, Joganic KJ, Fornaro M, Thornton GB & Altieri DC (1995). Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition. Proceedings of the National Academy of Sciences, USA, 92: 1505-1509.
    • 29. Cronstein BN (1994). Adhesion molecules in the pathogenesis of rheumatoid arthritis. Current Opinion in Rheumatology, 6: 300-304.
    • 30. Poston RN, Haskard DO, Coucher JR, Gall NP & Johnson-Tidy RR (1992). Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. American Journal of Pathology, 140: 665-673.
    • 31. Mata P, Alonso R, Lopez-Farre A, Ordovas JM, Lahoz C, Garces C, Caramelo C, Codoceo R, Blazquez E & de Oya M (1996). Effect of dietary fat saturation on LDL oxidation and monocyte adhesion to human endothelial cells in vitro. Arteriosclerosis, Thrombosis, and Vascular Biology , 16: 1347-1355.
    • 32. Mulrooney HM & Grimble RF (1993). Influence of butter and of corn, coconut and fish oils on the effects of recombinant human tumour necrosis factor-α in rats. Clinical Science, 84: 105-112.
    • 33. Besler HT & Grimble RF (1995). Comparison of the modulatory influence of maize and olive oils and butter on metabolic responses to endotoxin in rats. Clinical Science, 88: 59-66.
    • 34. Sanderson P, Yaqoob P & Calder PC (1995). Effects of dietary lipid manipulation upon graft vs host and host vs graft responses in the rat. Cellular Immunology, 164: 240-247.
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