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Publisher: Elsevier
Languages: English
Types: Article
Subjects:

Classified by OpenAIRE into

mesheuropmc: technology, industry, and agriculture, polycyclic compounds, carbohydrates (lipids), lipids (amino acids, peptides, and proteins)
Batch synthesis of sulphobutyl ether β-cyclodextrin (also known as SBE-β-CD or SBECD) is a process effectively divided into three main stages, i.e. initial reagent dissolution, a sulphoalkylation reaction and final reaction quenching. This reaction is followed by downstream processing and purification, and ultimate isolation of the solid SBECD material. However, a feature associated with using this synthetic method is that a high proportion of lower substituted SBECD is observed. There is therefore a need to provide an improved synthetic method for producing higher substituted cyclodextrins.\ud \ud The authors here present a Continuous Tank Reactor (CTR) method for preparing sulphobutyl ether-cyclodextrins. The method comprises first contacting cyclodextrin with a base to form activated cyclodextrin. The method then involves separately contacting the activated cyclodextrin with an 1,4-butane sultone to form sulphoalkyl ether-cyclodextrin.\ud \ud The activation reaction is carried out in batch synthesis mode and the sulphoalkylation reaction is carried out under continuous flow conditions resulting in a novel method for the synthesis of highly derivatised cyclodextrins.\ud \ud The work is particularly concerned with producing controlled substitution in sulphobutyl ether β-cyclodextrins and novel compositions of highly substituted sulphoalkyl ether β-cyclodextrins are described.
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    • 100 101 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 1993. An AM1 molecular orbital study of a-D-glucose and B-maltose: 6. Jindrich J, Pitha J, Lindberg B, Seffers P, Harata K. 1995, Regioselectivity of 8. Szeman, J. , Csabai, K. , Kekesi, K. , Szente, L. , Varga, G. , 2006, Novel 9. Szeman, J. , Sohajda, T. , Olah, E. , Varga, E. , Csabai, K. , Varga, G. ,
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