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Matthew, Dionne N.Y
Languages: English
Types: Doctoral thesis
Heart rate variability (HRV) reflects the modulation of cardiac function by autonomic and other physiological regulatory systems. HRV is accepted as a reliable and reproducible technique for assessing autonomic activity. Impaired autonomic function (measured through a reduction in HRV) predicts mortality and is associated with several disease states. Excess adiposity is also associated with higher risk of cardiovascular diseases, type 2 diabetes, cancer and other health disorders. Body composition analysis involves the measurement of adipose tissue and other components such as muscle, bone and minerals in the human body. The relationship between excess adiposity and autonomic dysfunction has also been reported. The present thesis is divided into three parts: (i) validation studies, (ii) control studies and (iii) heart failure studies. The first validation study compares HRV (rMSSD) measured simultaneously with a Polar s810i and Ithlete on an iPod touch, in both healthy and heart failure populations. The second study examines measurement options for body composition by comparing several bioelectrical impedance analysis devices in a healthy population. Four studies were then undertaken with control subjects, assessing differences in gender, ethnicity and lifestyle factors using the devices validated in the previous chapters. Finally, Ithlete software was used with heart failure participants to gauge the feasibility of using the device daily and obtaining user feedback. Ithlete was then used in a cardiac rehabilitation programme to help participants get the most out of the programme, by guiding their exercise to rest ratio. The relationships between HRV, HR and body composition have been explored in this research work and have contributed to the knowledge around how these relationships can be used in healthcare. The benefit of novel devices to measure these relationships in both clinical and healthy populations has also been demonstrated, with an emphasis on low cost devices with good reliability.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • APPENDIX V Posters ..........................................................................................395 APPENDIX VI Ethical Clearance letter ................................................................397 Marijon, E., Boveda, S., Chevalier, P., Bulava, A., Winter, J.B., Lambiez, M. & Defaye, P. 2010, 'Monitoring of heart rate variability in heart failure patients with cardiac resynchronisation therapy: Interest of continuous and didactic algorithm', International Journal of Cardiology, vol. 144, no. 1, pp. 166-9.
    • Murad, K., Brubaker, P.H., Fitzgerald, D.M., Morgan, T.M., Goff, D.C., Jr., Soliman, E.Z., Eggebeen, J.D. & Kitzman, D.W. 2012, 'Exercise training improves heart rate variability in older patients with heart failure: a randomized, controlled, single-blinded trial', Congestive Heart Failure, vol. 18, no. 4, pp. 192-7.
    • Nolan, J., Batin, P.D., Andrews, R., Lindsay, S.J., Brooksby, P., Mullen, M., Baig, W., Flapan, A.D., Cowley, A., Prescott, R.J., Neilson, J.M.M. & Fox, K.A.A. 1998, 'Prospective Study of Heart Rate Variability and Mortality in Chronic Heart Failure', Circulation, vol. 98, pp. 1510-6.
    • Ponikowski, P., Anker, S.D., Chua, T.P., Szelemej, R., Piepoli, M., Adamopoulos, S., Webb-Peploe, K., Harrington, D., Banasiak, W., Wrabec, K. & Coats, A.J. 1997, 'Depressed heart rate variability as an independent predictor of death in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy', The American Journal of Cardiology, vol. 79, no. 12, pp. 1645-50.
    • Routledge, F.S., Campbell, T.S., McFetridge-Durdle, J.A. & Bacon, S.L. 2010, 'Improvements in heart rate variability with exercise therapy', Canadian Journal of Cardiology, vol. 26, no. 6, pp. 303-12.
    • Sandercock, G.R.H. & Brodie, D.A. 2006, 'The Role of Heart Rate Variability in Prognosis for Different Modes of Death in Chronic Heart Failure', Pacing and Clinical Electrophysiology, vol. 29, no. 8, pp. 892-904.
    • Scherr, D., Kastner, P., Kollmann, A., Hallas, A., Auer, J., Krappinger, H., Schuchlenz, H., Stark, G., Grander, W., Jakl, G., Schreier, G. & Fruhwald, F.M. 2009, 'Effect of home-based telemonitoring using mobile phone technology on the outcome of heart failure patients after an episode of acute decompensation: randomized controlled trial', Journal of Medical Internet Research, vol. 11, no. 3, p. e34.
    • Selig, S.E., Carey, M.F., Menzies, D.G., Patterson, J., Geerling, R.H., Williams, A.D., Bamroongsuk, V., Toia, D., Krum, H. & Hare, D.L. 2004, 'Moderateintensity resistance exercise training in patients with chronic heart failure improves strength, endurance, heart rate variability, and forearm blood flow', Journal of Cardiac Failure, vol. 10, no. 1, pp. 21-30.
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