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Muller-Pebody, B; Crowcroft, NS; Zambon, MC; Edmunds, WJ (2006)
Publisher: Cambridge University Press (CUP)
Languages: English
Types: Article
Despite the importance of lower respiratory-tract infection (LRI) in causing hospitalizations in elderly patients (>or=65 years of age) and recent advances in vaccine development, a complete picture of the causative organisms is not available. All hospital discharge diagnoses (ICD-10 code) for LRI in elderly patients in England during 1995-1998 were reviewed. Using known seasonality in potential causative agents of LRI, the contribution of different respiratory pathogens to hospitalizations coded as 'unspecified LRI' was estimated by multiple linear regression analysis. Ninety-seven per cent of 551633 LRI-associated diagnoses had no specific organism recorded. From the statistical model the estimated proportions of admissions attributable to different pathogens were applied to calculate estimated hospitalization rates: 93.9 hospitalizations/10000 population aged >or=65 years due to S. pneumoniae, 22.9 to influenza virus, 22.3 to H. influenzae, 17.0 to whooping cough, and 12.8 to respiratory syncytial virus. There is enormous potential to improve health using existing vaccines and those under development.
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    • 1. Falsey AR, et al. Viral respiratory infections in institutionalized elderly : clinical and epidemiological findings. Journal of the American Geriatrics Society 2001 ; 40 : 115-119.
    • 2. Han LL, James PA, Anderson LJ. Respiratory syncytial virus pneumonia among the elderly : an assessment of disease burden. Journal of Infectious Diseases 1999 ; 179 : 25-30.
    • 3. Sorvillo FJ, et al. An outbreak of respiratory syncytial virus pneumonia in a nursing home for the elderly. Journal of Infection 1984 ; 9 : 252-256.
    • 4. Gu¨ ris D, et al. Changing epidemiology of pertussis in the United States : increasing reported incidence among adolescents and adults, 1990-1996. Clinical Infectious Diseases 1999 ; 28 : 1230-1237.
    • 5. Duthie EH, Abbasi AA. Laboratory testing : current recommendations for older adults. Geriatrics 1991 ; 46 : 41-45, 49-50.
    • 6. Dudas RA, Karron RA. Respiratory syncytial virus vaccines. Clinical Microbiology Reviews 1998 ; 11 : 430-439.
    • 7. Department of Health. Flu key documents (http:// www.dh.gov.uk/PolicyAndGuidance/HealthAndSocial CareTopics/Flu/FluGeneralInformation/fs/en). Accessed 4 May 2005.
    • 8. Johnson S, et al. Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus (RSV). Journal of Infectious Diseases 1997 ; 176 : 1215-1224.
    • 9. Marston BJ, et al. Incidence of community-acquired pneumonia requiring hospitalization. Archives of Internal Medicine 1997 ; 157 : 1709-1718.
    • 10. Crowcroft NS, Cutts F, Zambon MC. Respiratory syncytial virus : an underestimated cause of respiratory infection, with prospects for a vaccine. Communicable Diseases and Public Health 1999 ; 2 : 234-241.
    • 11. Ryan MJ, et al. Hospital admissions attributable to rotavirus infection in England and Wales. Journal of Infectious Diseases 1996 ; 174 (Suppl. 1) : S12-S18.
    • 12. Mu¨ ller-Pebody B, et al. Contribution of RSV to bronchiolitis and pneumonia-associated hospitalisations in English children, April 1995-March 1998. Epidemiology and Infection 2002 ; 129 : 99-106.
    • 13. Smith MD, et al. Invasive pneumococcal infection in South and West England. Epidemiology and Infection 1998 ; 120 : 117-123.
    • 14. Fleming DM, Cross KW. Respiratory syncytial virus or influenza ? Lancet 1993 ; 342 : 1507-1510.
    • 15. Van den Hoogen BG, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nature Medicine 2001 ; 7 : 719-724.
    • 16. Lim WS, et al. Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital : implications for management guidelines. Thorax 2001 ; 56 : 296-301.
    • 17. Falsey AR, et al. Respiratory syncytial virus infection in elderly and high-risk adults. New England Journal of Medicine 2005 ; 352 : 1749-1759.
    • 18. Butler JC, Schuchat A. Epidemiology of pneumococcal infections in the elderly. Drugs and Aging 1999 ; 15 (Suppl. 1) : 11-19.
    • 19. Gupta S, Ferguson N, Anderson R. Chaos, persistence, and evolution of strain structure in antigenically diverse infectious agents. Science 1998 ; 280 : 912-915.
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