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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Publisher: The Company of Biologists Ltd.
Languages: English
Types: Article
Subjects: QH301
Roughly half of all animal somatic cell spindles assemble by the\ud classical prophase pathway, in which the centrosomes separate\ud ahead of nuclear envelope breakdown (NEBD). The remainder\ud assemble by the prometaphase pathway, in which the\ud centrosomes separate following NEBD. Why cells use dual\ud pathway spindle assembly is unclear. Here, by examining the\ud timing of NEBD relative to the onset of Eg5-mEGFP loading to\ud centrosomes, we show that a time window of 9.2 ± 2.9 min is\ud available for Eg5-driven prophase centrosome separation ahead\ud of NEBD, and that those cells that succeed in separating their\ud centrosomes within this window subsequently show .3-fold\ud fewer chromosome segregation errors and a somewhat faster\ud mitosis. A longer time window would allow more cells to\ud complete prophase centrosome separation and further reduce\ud segregation errors, but at the expense of a slower mitosis. Our\ud data reveal dual pathway mitosis in a new light, as a substantive\ud strategy that increases both the speed and the fidelity of mitosis.

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