LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Publisher: Society for Neuroscience
Languages: English
Types: Article
Subjects: QH301
The striatum has a well documented role in procedural learning and memory. However, the synaptic and molecular mechanisms of acquisition and storage of this form of memory remain poorly understood. We examined procedural memory and plasticity in transgenic mice reversibly expressing a dominant-negative cAMP response element-binding protein (CREB) mutant in the dorsal striatum. In these transgenic mice, corticostriatal long-term potentiation and depression are abolished, indicating that CREB function is essential for bidirectional long-term synaptic plasticity in this structure. Importantly, CREB-deficient animals show reversible alterations in several forms of striatum-dependent memory, including footshock avoidance learning and "response" learning in the cross maze. These findings implicate transcriptional regulation by CREB family transcription factors in striatum-dependent information processing and provide the first clear correlation between procedural learning and memory and synaptic plasticity at the corticostriatal synapse.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • Barco A, Pittenger C, Kandel ER (2003) CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects. Expert Opin Ther Targets 7:101-114.
    • Calabresi P, Pisani A, Mercuri NB, Bernardi G (1992a) Long term potentiation in the striatum is unmasked by removing the voltage-dependent blockade of NMDA receptor channel. Eur J Neurosci 4:929 -935.
    • Calabresi P, Maj R, Pisani A, Mercuri NB, Bernardi G (1992b) Long-term synaptic depression in the striatum: physiological and pharmacological characterization. J Neurosci 12:4224 - 4233.
    • Carlezon Jr WA, Duman RS, Nestler EJ (2005) The many faces of CREB. Trends Neurosci 28:436 - 445.
    • Chao J, Nestler EJ (2004) Molecular neurobiology of drug addiction. Annu Rev Med 55:113-132.
    • Eichenbaum H, Cohen NJ (2001) From conditioning to conscious recollection: memory systems of the brain. Oxford: Oxford UP.
    • Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8:1481-1489.
    • Fasano S, Brambilla R (2002) Cellular mechanisms of striatum-dependent behavioral plasticity and drug addiction. Curr Mol Med 2:649 - 665.
    • Huang YY, Pittenger C, Kandel ER (2004) A form of long-lasting, learningrelated synaptic plasticity in the hippocampus induced by heterosynaptic low-frequency pairing. Proc Natl Acad Sci USA 101:859 - 864.
    • Hyman SE, Malenka RC (2001) Addiction and the brain: the neurobiology of compulsion and its persistence. Nat Rev Neurosci 2:695-703.
    • Malenka RC, Bear MF (2004) LTP and LTD: an embarrassment of riches. Neuron 44:5-21.
    • Martin SJ, Grimwood PD, Morris RG (2000) Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci 23:649 -711.
    • Mazzucchelli C, Vantaggiato C, Ciamei A, Fasano S, Porrazzo A, Orban PC, Pakhotin P, Krezel W, Wezl H, Wolfer DP, Pages G, Valverde O, Marowsky A, Maldonado R, Ehrengruber MU, Cestari V, Lipp H-P, Chapman PF, Pouyssegur J, Brambilla R (2002) Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron 34:807- 820.
    • Packard MG (1999) Glutamate infused posttraining into the hippocampus or caudate-putamen differentially strengthens place and response learning. Proc Natl Acad Sci USA 96:12881-12886.
    • Packard MG, Knowlton BJ (2002) Learning and memory functions of the basal ganglia. Annu Rev Neurosci 25:563-593.
    • Packard MG, McGaugh JL (1996) Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning. Neurobiol Learn Mem 65:65-72.
    • Passino E, Middei S, Restivo L, Bertaina-Anglade V, Ammassari-Teule M (2002) Genetic approach to variability of memory systems: analysis of place vs. response learning and fos-related expression in hippocampal and striatal areas of C57BL/6 and DBA/2 mice. Hippocampus 12:63-75.
    • Pittenger C, Huang YY, Paletzki RF, Bourtchouladze R, Scanlin H, Vronskaya S, Kandel ER (2002) Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampusdependent spatial memory. Neuron 34:447- 462.
    • Prado-Alcala RA, Grinberg ZJ, Arditti ZL, Garcia MM, Prieto HG, BrustCarmona H (1975) Learning deficits produced by chronic and reversible lesions of the corpus striatum in rats. Physiol Behav 15:283-287.
    • Schutz RA, Izquierdo I (1979) Effect of brain lesions on rat shuttle behavior in four different tests. Physiol Behav 23:97-105.
    • Sgambato V, Pages C, Rogard M, Besson MJ, Caboche J (1998) Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation. J Neurosci 18:8814 - 8825.
    • Voorn P, Vanderschuren LJ, Groenewegen HJ, Robbins TW, Pennartz CM (2004) Putting a spin on the dorsal-ventral divide of the striatum. Trends Neurosci 27:468 - 474.
    • White NM (1997) Mnemonic functions of the basal ganglia. Curr Opin Neurobiol 7:164 -169.
    • White NM, McDonald RJ (2002) Multiple parallel memory systems in the brain of the rat. Neurobiol Learn Mem 77:125-184.
    • Wise RA (2004) Dopamine, learning and motivation. Nat Rev Neurosci 5:483- 494.
    • Yin HH, Knowlton BJ (2004) Contributions of striatal subregions to place and response learning. Learn Mem 11:459 - 463.
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article