LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Adamatzky, A. (2016)
Publisher: Elsevier
Languages: English
Types: Article
Subjects:

Classified by OpenAIRE into

mesheuropmc: fungi
Left-right patterning and lateralized behaviour is an ubiquitous aspect of plants and animals. The mechanisms linking cellular chirality to the large-scale asymmetry of multicellular structures are incompletely understood, and it has been suggested that the chirality of living cells is hardwired in their cytoskeleton. We examined the question of biased asymmetry in a unique organism: the slime mould \emph{Physarum polycephalum}, which is unicellular yet possesses macroscopic, complex structure and behaviour. In laboratory experiment using a T-shape, we found that \emph{Physarum} turns right in more than 74\% of trials.The results are in agreement with previously published studies on asymmetric movement of muscle cells, neutrophils, liver cells and growing neural filaments, and for the first time reveal the presence of consistently-biased laterality in the fungi kingdom. Exact mechanisms of the slime mould’s direction preference remain unknown.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • [1] Tatsuya Abe, Siripong Thitamadee, and Takashi Hashimoto. Microtubule defects and cell morphogenesis in the lefty1lefty2 tubulin mutant of arabidopsis thaliana. Plant and cell physiology, 45(2):211{220, 2004.
    • [2] Andrew Adamatzky. Physarum machines: computers from slime mould. World Scienti c, 2010.
    • [3] Andrew Adamatzky, editor. Advances in Physarum Machines. Springer, 2016.
    • [4] Romas Aleliunas, Richard M Karp, Richard J Lipton, Laszlo Lovasz, and Charles Racko . Random walks, universal traversal sequences, and the complexity of maze problems. In FOCS, volume 79, pages 218{223, 1979.
    • [5] Dean M Anderson and Leigh W Murray. Sheep laterality. Laterality: Asymmetries of Body, Brain and Cognition, 18(2):179{193, 2013.
    • [6] Athanasios Armakolas and Amar JS Klar. Left-right dynein motor implicated in selective chromatid segregation in mouse cells. Science, 315(5808):100{101, 2007.
    • [7] Sherry Aw and Michael Levin. What's left in asymmetry? Developmental Dynamics, 237(12):3453{3463, 2008.
    • [8] Sherry Aw and Michael Levin. Is left-right asymmetry a form of planar cell polarity? Development, 136(3):355{366, 2009.
    • [9] Michal Babula. Simulated maze solving algorithms through unknown mazes. Organizing and Program Committee, page 13, 2009.
    • [10] Basudha Basu and Martina Brueckner. Chapter six cilia: Multifunctional organelles at the center of vertebrate left{right asymmetry. Current topics in developmental biology, 85:151{174, 2008.
    • [11] Aaron J Bell, Peter Satir, and Gary W Grimes. Mirror-imaged doublets of tetmemena pustulata: Implications for the development of left{right asymmetry. Developmental biology, 314(1):150{160, 2008.
    • [12] VL Bianki and IM Sheiman. Preference for a direction of movement in a t-shaped maze by the mealworm. Zhurnal vysshei nervnoy deiatelnosti imeni IP Pavlova. Journal of Higher Nervous Activity, 35(5):988, 1985.
    • [13] VL Bianki, IM Sheiman, and EV Zubina. The preference for movement direction in a t-maze in planarians. Zhurnal vysshei nervnoi deiatelnosti imeni IP Pavlova. Journal of Higher Nervous Activity, 40(1):102{107, 1989.
    • [14] Leonard Bosgraaf and Peter J. M. Van Haastert. The ordered extension of pseudopodia by amoeboid cells in the absence of external cues. PloS one, 4(4):e5253, 2009.
    • [15] ET Brown, SJ Green, and KP Sinha. The in uence of rock anisotropy on hole deviation in rotary drillinga review. In International Journal of Rock Mechanics and Mining Sciences & Geomechanics Abstracts, volume 18, pages 387{401. Elsevier, 1981.
    • [16] NIGEL A Brown and LEWIS Wolpert. The development of handedness in left/right asymmetry. Development, 109(1):1{9, 1990.
    • [17] Peter Brugger, Ervin Macas, and Jurgen Ihlemann. Do sperm cells remember? Behavioural brain research, 136(1):325{328, 2002.
    • [18] LB Buravkova and Yu A Romanov. The role of cytoskeleton in cell changes under condition of simulated microgravity. Acta astronautica, 48(5):647{650, 2001.
    • [19] Brett Casey and Brian P Hackett. Left{right axis malformations in man and mouse. Current opinion in genetics & development, 10(3):257{261, 2000.
    • [20] Ting-Hsuan Chen, Je rey J Hsu, Xin Zhao, Chunyan Guo, Margaret N Wong, Yi Huang, Zongwei Li, Alan Gar nkel, Chih-Ming Ho, Yin Tintut, et al. Leftright symmetry breaking in tissue morphogenesis via cytoskeletal mechanics. Circulation research, 110(4):551{559, 2012.
    • [21] Meryl S Cohen, Robert H Anderson, Mitchell I Cohen, Andrew M Atz, Mark Fogel, Peter J Gruber, Leo Lopez, Jonathan J Rome, and Paul M Weinberg. Controversies, genetics, diagnostic assessment, and outcomes relating to the heterotaxy syndrome. Cardiology in the Young, 17(S4):29{43, 2007.
    • [22] Susan J Crawford-Young. E ects of microgravity on cell cytoskeleton and embryogenesis. International journal of developmental biology, 50(2/3):183, 2006.
    • [23] GA Den Boer, GD Van Albada, LO Hertzberger, C Koburg, and M Mergel. The marie autonomous mobile robot1. 1993.
    • [24] Joseph Frankel. Intracellular handedness in ciliates. Biological asymmetry and handedness, (162):73, 1991.
    • [25] Elisa Frasnelli. Brain and behavioral lateralization in invertebrates. Frontiers in psychology, 4, 2013.
    • [26] Andrew Goldish. Noisy wall following and maze navigation through genetic programming. In Proceedings of the First Annual Conference on Genetic Programming, pages 423{423. MIT Press, 1996.
    • [27] Brian P Hackett. Formation and malformation of the vertebrate left-right axis. Current molecular medicine, 2(1):39{66, 2002.
    • [28] Marnie E Halpern, Onur Gunturkun, William D Hopkins, and Lesley J Rogers. Lateralization of the vertebrate brain: taking the side of model systems. The Journal of neuroscience, 25(45):10351{10357, 2005.
    • [29] Anne M Heacock and Bernard W Agrano . Clockwise growth of neurites from retinal explants. Science, 198(4312):64{66, 1977.
    • [30] Linley K Jesson and Spencer CH Barrett. The comparative biology of mirrorimage owers. International Journal of Plant Sciences, 164(S5):S237{S249, 2003.
    • [31] Akio Katsuki, Keizo Sakuma, Koichi Tabuchi, Hiromichi Onikura, Hisashi Akiyoshi, and Yasushi Nakamuta. The in uence of tool geometry on axial hole deviation in deep drilling: Comparison of single-and multi-edge tools. JSME international journal, 30(265):1167{1174, 1987.
    • [33] Amar JS Klar. A model for speci cation of the left-right axis in vertebrates. Trends in Genetics, 10(11):392{396, 1994.
    • [34] EL Kordyum. A role for the cytoskeleton in plant cell gravisensitivity and ca 2+-signaling in microgravity. Cell biology international, 27(3):219{221, 2003.
    • [35] Yasuhiro Kumei, Sadao Morita, Hisako Katano, Hideo Akiyama, Masahiko Hirano, Kei'ichi Oyha, and Hitoyata Shimokawa. Microgravity signal ensnarls cell adhesion, cytoskeleton, and matrix proteins of rat osteoblasts. Annals of the New York Academy of Sciences, 1090(1):311{317, 2006.
    • [36] Annette K Lewis and Paul C Bridgman. Nerve growth cone lamellipodia contain two populations of actin laments that di er in organization and polarity. The Journal of cell biology, 119(5):1219{1243, 1992.
    • [37] Jing Li, Shu Zhang, Jun Chen, Tingyuan Du, Yongchun Wang, and Zongren Wang. Modeled microgravity causes changes in the cytoskeleton and focal adhesions, and decreases in migration in malignant human mcf-7 cells. Protoplasma, 238(1-4):23{33, 2009.
    • [38] Maria Lobikin, Gang Wang, Jingsong Xu, Yi-Wen Hsieh, Chiou-Fen Chuang, Joan M Lemire, and Michael Levin. Early, nonciliary role for microtubule proteins in left{right patterning is conserved across kingdoms. Proceedings of the National Academy of Sciences, 109(31):12586{12591, 2012.
    • [39] WC Mcgrew. Right hand, left hand. the origins of asymmetry in brains, bodies, atoms and cultures, 2005.
    • [40] MJ Morgan and IC McManus. The relationship between brainedness and handedness. Aphasia, pages 85{130, 1988.
    • [41] Tamara Mun~oz-Nortes, David Wilson-Sanchez, Hector Candela, and Jose Luis Micol. Symmetry, asymmetry, and the cell cycle in plants: known knowns and some known unknowns. Journal of experimental botany, page ert476, 2014.
    • [42] Sundar Ram Naganathan, Sebastian Furthauer, Masatoshi Nishikawa, Frank Julicher, and Stephan W Grill. Active torque generation by the actomyosin cell cortex drives left{right symmetry breaking. eLife, 3:e04165, 2014.
    • [43] Toshiyuki Nakagaki, Hiroyasu Yamada, and Agota Toth. Intelligence: Mazesolving by an amoeboid organism. Nature, 407(6803):470{470, 2000.
    • [44] E MARLO Nelsen, Joseph Frankel, and LESLIE M Jenkins. Non-genic inheritance of cellular handedness. Development, 105(3):447{456, 1989.
    • [45] G Orly, M Naoz, and NS Gov. Physical model for the geometry of actin-based cellular protrusions. Biophysical journal, 107(3):576{587, 2014.
    • [46] A Richard Palmer. From symmetry to asymmetry: phylogenetic patterns of asymmetry variation in animals and their evolutionary signi cance. Proceedings of the National Academy of Sciences, 93(25):14279{14286, 1996.
    • [47] Hilde Peeters and Koen Devriendt. Human laterality disorders. European journal of medical genetics, 49(5):349{362, 2006.
    • [48] Dayong Qiu, Shing-Ming Cheng, Laryssa Wozniak, Megan McSweeney, Emily Perrone, and Michael Levin. Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left-right asymmetry. Developmental dynamics, 234(1):176{189, 2005.
    • [49] Ann F Ramsdell. Left{right asymmetry and congenital cardiac defects: getting to the heart of the matter in vertebrate left{right axis determination. Developmental biology, 288(1):1{20, 2005.
    • [50] Angel Raya and Juan Carlos Izpisua Belmonte. Left{right asymmetry in the vertebrate embryo: from early information to higher-level integration. Nature Reviews Genetics, 7(4):283{293, 2006.
    • [51] Adil MJ Sadik, Maruf Dhali, Hasib MAB Farid, Tafhim U Rashid, A Syeed, et al. A comprehensive and comparative study of maze-solving techniques by implementing graph theory. In Arti cial Intelligence and Computational Intelligence (AICI), 2010 International Conference on, volume 1, pages 52{ 56. IEEE, 2010.
    • [52] Stephan Sauer and Amar JS Klar. Left-right symmetry breaking in mice by left-right dynein may occur via a biased chromatid segregation mechanism, without directly involving the nodal gene. Frontiers in oncology, 2, 2012.
    • [53] Mukesh Sharma and Kaizen Robeonics. Algorithms for micro-mouse. In Future Computer and Communication, 2009. ICFCC 2009. International Conference on, pages 581{585. IEEE, 2009.
    • [54] Hai Song, Jianxin Hu, Wen Chen, Gene Elliott, Philipp Andre, Bo Gao, and Yingzi Yang. Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature, 466(7304):378{382, 2010.
    • [58] Atsushi Tamada, Satoshi Kawase, Fujio Murakami, and Hiroyuki Kamiguchi. Autonomous right-screw rotation of growth cone lopodia drives neurite turning. The Journal of cell biology, 188(3):429{441, 2010.
    • [59] Kiichiro Taniguchi, Reo Maeda, Tadashi Ando, Takashi Okumura, Naotaka Nakazawa, Ryo Hatori, Mitsutoshi Nakamura, Shunya Hozumi, Hiroo Fujiwara, and Kenji Matsuno. Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis. Science, 333(6040):339{341, 2011.
    • [60] Yee Han Tee, Tom Shemesh, Visalatchi Thiagarajan, Rizal Fajar Hariadi, Karen L Anderson, Christopher Page, Niels Volkmann, Dorit Hanein, Sivaraj Sivaramakrishnan, Michael M Kozlov, et al. Cellular chirality arising from the self-organization of the actin cytoskeleton. Nature cell biology, 2015.
    • [61] Siripong Thitamadee, Kazuko Tuchihara, and Takashi Hashimoto. Microtubule basis for left-handed helical growth in arabidopsis. Nature, 417(6885):193{196, 2002.
    • [62] Laura N Vandenberg, Joan M Lemire, and Michael Levin. Its never too early to get it right: A conserved role for the cytoskeleton in left-right asymmetry. Communicative & integrative biology, 6(6):12586{91, 2013.
    • [63] Laura N Vandenberg and Michael Levin. Far from solved: a perspective on what we know about early mechanisms of left{right asymmetry. Developmental Dynamics, 239(12):3131{3146, 2010.
    • [64] Laura N Vandenberg and Michael Levin. A uni ed model for left{right asymmetry? comparison and synthesis of molecular models of embryonic laterality. Developmental biology, 379(1):1{15, 2013.
    • [65] Leo Q Wan, Kacey Ronaldson, Miri Park, Grace Taylor, Yue Zhang, Je rey M Gimble, and Gordana Vunjak-Novakovic. Micropatterned mammalian cells exhibit phenotype-speci c left-right asymmetry. Proceedings of the National Academy of Sciences, 108(30):12295{12300, 2011.
    • [66] Leo Q Wan and Gordana Vunjak-Novakovic. Micropatterning chiral morphogenesis. Communicative & integrative biology, 4(6):745{748, 2011.
    • [67] Michel Wright, Catherine Albertini, Viviane Planques, Isabelle Salles, Bernard Ducommun, Catherine Gely, Haleh Akhavan-Niaki, Luis Mir, Andre Moisand, and Marie-Louise Oustrin. Microtubule cytoskeleton and morphogenesis in the amoebae of the myxomycete physarum polycephalum. Biology of the Cell, 63(2):239{248, 1988.
    • [68] Jingsong Xu, Alexandra Van Keymeulen, Nicole M Wakida, Pete Carlton, Michael W Berns, and Henry R Bourne. Polarity reveals intrinsic cell chirality. Proceedings of the National Academy of Sciences, 104(22):9296{9300, 2007.
    • [69] Hiroaki Yamanaka and Shigeru Kondo. Rotating pigment cells exhibit an intrinsic chirality. Genes to Cells, 20(1):29{35, 2015.
  • No similar publications.

Share - Bookmark

Cite this article