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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Hand, Sadiyah
Languages: English
Types: Doctoral thesis
Subjects: RJ
Asthma is a chronic respiratory disease with a prevalence that has increased worldwide over the past 40 years. Longitudinal cohort studies have been designed to determine associations between early life events and asthma prevalence. One such cohort is the Merthyr Allergy Prevention Study (MAPS). MAPS recruited high risk subjects, before birth, from a deprived population in South Wales. The original study was a randomised controlled trial (RCT) of either normal diet for the first four months of life, or a cows’ milk protein exclusion diet with soya formula milk supplementation if subjects were not breast fed. Subjects were subsequently followed up as part of a cohort study. The findings presented are based on the final follow up at age 23 years.\ud While there was a significant protective effect of breast feeding on wheeze at age 1, there was no evidence of an association with wheeze at age 23 years. The intervention arm of the RCT was associated with an increased risk of asthma and sensitisation at age 23 years.\ud There was tracking of both total serum IgE and positive skin prick test results over the years but there was no clear relationship between these two measures of allergy. Although the prevalence of atopy was low in childhood, there was still a clear association with this and wheeze later in life. Wheeze at age 3 years or older was an important determinant of asthma at age 23 years. There was a significant association between those who wheeze from age of 3 to age 23 years and atopic status at age 7 years.\ud In conclusion we have investigated a birth cohort from a relatively deprived area of South Wales and found characteristics in the first 7 years of life are critical in determining if asthma develops in early adulthood.
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    • 1. Weiss ST. Epidemiology and heterogeneity of asthma. Ann Allergy Asthma Immunol 2001; 87(1 Suppl 1): 5-8.
    • 2. Weiss ST. Environmental risk factors in childhood asthma. Clin Exp Allergy 1998; 28 Suppl 5: 29-34; discussion 50-1.
    • 3. UK A. Asthma Facts and FAQs. 2013. http://www.asthma.org.uk/asthmafacts-and-statistics (accessed 11th August 2013 2013).
    • 4. (ONS) OoNS. Avoidable mortality in England and Wales, 2012 - Reference table 1 (Excel sheet 165Kb) may 2014, 2012. http://www.ons.gov.uk/ons/datasetsandtables/index.html?pageSize=50&sortBy=none&sortDirection=none&newquery=asth ma&content-type=Reference+table&content-type=Dataset (accessed june 2014).
    • 5. Svanes C, Sunyer J, Plana E, et al. Early life origins of chronic obstructive pulmonary disease. Thorax 2010; 65(1): 14-20.
    • 6. Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006; 355(21): 2226-35.
    • 7. Pearce N, Ait-Khaled N, Beasley R, et al. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007; 62(9): 758-66.
    • 8. SIGN/BTS. British guideline on the management of asthma. Asthma priorities: influencing the agenda In: Scotland Hi, editor.; 2013.
    • 9. GINA. Global initiative for asthma2014.
    • http://www.ginasthma.org/local/uploads/files/GINA_Report_2015_May19.pdf (accessed 29th May 2015).
    • 10. Van Wonderen KE, Van Der Mark LB, Mohrs J, Bindels PJ, Van Aalderen WM, Ter Riet G. Different definitions in childhood asthma: how dependable is the dependent variable? Eur Respir J 2010; 36(1): 48-56.
    • 11. Asher MI, Weiland SK. The International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Steering Committee. Clin Exp Allergy 1998; 28 Suppl 5: 52- 66; discussion 90-1.
    • 12. European Community Respiratory Health S. Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS). Eur Respir J 1996; 9(4): 687-95.
    • 13. Burney PG, Laitinen LA, Perdrizet S, et al. Validity and repeatability of the IUATLD (1984) Bronchial Symptoms Questionnaire: an international comparison. Eur Respir J 1989; 2(10): 940-5.
    • 14. Peat JK, Toelle BG, Marks GB, Mellis CM. Continuing the debate about measuring asthma in population studies. Thorax 2001; 56(5): 406-11.
    • 15. Jenkins MA, Clarke JR, Carlin JB, et al. Validation of questionnaire and bronchial hyperresponsiveness against respiratory physician assessment in the diagnosis of asthma. Int J Epidemiol 1996; 25(3): 609-16.
    • 16. ISAAC. The ISAAC story2012, 2012.
    • http://isaac.auckland.ac.nz/story/background/toolbox.php#writtenT (accessed 31st May 2015).
    • 17. Chinn S, Jarvis D, Burney P, et al. Increase in diagnosed asthma but not in symptoms in the European Community Respiratory Health Survey. Thorax 2004; 59(8): 646-51.
    • 18. Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009; 64(6): 476-83.
    • 19. Anto JM, Sunyer J, Basagana X, et al. Risk factors of new-onset asthma in adults: a population-based international cohort study. Allergy 2010; 65(8): 1021-30.
    • 20. Nagel G, Buchele G, Weinmayr G, et al. Effect of breastfeeding on asthma, lung function and bronchial hyperreactivity in ISAAC Phase II. Eur Respir J 2009; 33(5): 993-1002.
    • 21. Beasley R, Clayton T, Crane J, et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme. Lancet 2008; 372(9643): 1039-48.
    • 22. Svanes C, Jarvis D, Chinn S, Omenaas E, Gulsvik A, Burney P. Early exposure to children in family and day care as related to adult asthma and hay fever: results from the European Community Respiratory Health Survey. Thorax 2002; 57(11): 945- 50.
    • 23. Svanes C, Zock JP, Anto J, et al. Do asthma and allergy influence subsequent pet keeping? An analysis of childhood and adulthood. J Allergy Clin Immunol 2006; 118(3): 691-8.
    • 24. Beasley R. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The Lancet 1998; 351(9111): 1225-32.
    • 25. (GNA) GAN. Global Asthma Report. http://www.globalasthmareport.org/burden/burden.php; 2014.
    • 26. Woolcock AaPAJ. Evidence for the increase in asthma worldwide. In: Chadwick DJaC, G, ed. the rising trends in asthma: wiley; 1997: 111-34.
    • 27. Woods RK, Walters EH, Wharton C, Watson N, Abramson M. The rising prevalence of asthma in young Melbourne adults is associated with improvement in treatment. Ann Allergy Asthma Immunol 2001; 87(2): 117-23.
    • 28. Wickens K, Barry D, Friezema A, et al. Obesity and asthma in 11-12 year old New Zealand children in 1989 and 2000. Thorax 2005; 60(1): 7-12.
    • 29. Haahtela T, Lindholm H, Bjorksten F, Koskenvuo K, Laitinen LA. Prevalence of asthma in Finnish young men. BMJ 1990; 301(6746): 266-8.
    • 30. Brogger J, Bakke P, Eide GE, Johansen B, Andersen A, Gulsvik A. Long-term changes in adult asthma prevalence. Eur Respir J 2003; 21(3): 468-72.
    • 31. Anderson HR, Gupta R, Strachan DP, Limb ES. 50 years of asthma: UK trends from 1955 to 2004. Thorax 2007; 62(1): 85-90.
    • 32. Burr ML, Wat D, Evans C, Dunstan FD, Doull IJ. Asthma prevalence in 1973, 1988 and 2003. Thorax 2006; 61(4): 296-9.
    • 33. Johansson SG, Bennich H. Immunological studies of an atypical (myeloma) immunoglobulin. Immunology 1967; 13(4): 381-94.
    • 34. Arshad SH, Tariq SM, Matthews S, Hakim E. Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study. Pediatrics 2001; 108(2): E33.
    • 35. Holt PG, McMenamin C, Nelson D. Primary sensitisation to inhalant allergens during infancy. Pediatric Allergy and Immunology 1990; 1(1): 3-13.
    • 36. Cullinan P, MacNeill SJ, Harris JM, et al. Early allergen exposure, skin prick responses, and atopic wheeze at age 5 in English children: a cohort study. Thorax 2004; 59(10): 855-61.
    • 37. Von Linstow ML, Porsbjerg C, Ulrik CS, Nepper-Christensen S, Backer V. Prevalence and predictors of atopy among young Danish adults. Clin Exp Allergy 2002; 32(4): 520-5.
    • 38. Court CS, Cook DG, Strachan DP. Comparative epidemiology of atopic and non-atopic wheeze and diagnosed asthma in a national sample of English adults. Thorax 2002; 57(11): 951-7.
    • 39. Lau S, Illi S, Platts-Mills TA, et al. Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood--report of the German Multicentre Allergy Study (MAS 90). Allergy 2005; 60(6): 766-73.
    • 40. Warner JA, Miles EA, Jones AC, Quint DJ, Colwell BM, Warner JO. Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema? Clin Exp Allergy 1994; 24(5): 423-30.
    • 41. Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989; 320(5): 271-7.
    • 42. Plaschke PP, Janson C, Norrman EVA, BjÖRnsson E, EllbjÄR S, JÄRvholm B. Onset and Remission of Allergic Rhinitis and Asthma and the Relationship with Atopic Sensitization and Smoking. American Journal of Respiratory and Critical Care Medicine 2000; 162(3): 920-4.
    • 43. WAO. World Allergy Organization white book on allergy 2011-12. 2011.
    • 44. Host A, Halken S. The role of allergy in childhood asthma. Allergy 2000; 55(7): 600-8.
    • 45. Hoppin JA, Jaramillo R, Salo P, Sandler DP, London SJ, Zeldin DC. Questionnaire predictors of atopy in a US population sample: findings from the National Health and Nutrition Examination Survey, 2005-2006. Am J Epidemiol 2011; 173(5): 544-52.
    • 46. Sears MR, Burrows B, Flannery EM, Herbison GP, Holdaway MD. Atopy in childhood. I. Gender and allergen related risks for development of hay fever and asthma. Clin Exp Allergy 1993; 23(11): 941-8.
    • 47. Sears MR, Burrows B, Herbison GP, Holdaway MD, Flannery EM. Atopy in childhood. II. Relationship to airway responsiveness, hay fever and asthma. Clin Exp Allergy 1993; 23(11): 949-56.
    • 48. Simpson BM, Custovic A, Simpson A, et al. NAC Manchester Asthma and Allergy Study (NACMAAS): risk factors for asthma and allergic disorders in adults. Clin Exp Allergy 2001; 31(3): 391-9.
    • 49. Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006; 368(9537): 763-70.
    • 50. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299(6710): 1259-60.
    • 51. Martinez FD. Role of viral infections in the inception of asthma and allergies during childhood: could they be protective? Thorax 1994; 49(12): 1189-91.
    • 52. Holt PG. Environmental factors and primary T-cell sensitisation to inhalant allergens in infancy: reappraisal of the role of infections and air pollution. Pediatr Allergy Immunol 1995; 6(1): 1-10.
    • 53. Matricardi PM, Rosmini F, Riondino S, et al. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 2000; 320(7232): 412-7.
    • 54. Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science 1997; 275(5296): 77-9.
    • 55. Castro-Rodriguez JA, Garcia-Marcos L, Alfonseda Rojas JD, Valverde-Molina J, Sanchez-Solis M. Mediterranean diet as a protective factor for wheezing in preschool children. J Pediatr 2008; 152(6): 823-8, 8 e1-2.
    • 56. Wickens K, Barry D, Friezema A, et al. Fast foods - are they a risk factor for asthma? Allergy 2005; 60(12): 1537-41.
    • 57. Ellwood P, Asher MI, Garcia-Marcos L, et al. Do fast foods cause asthma, rhinoconjunctivitis and eczema? Global findings from the International Study of Asthma and Allergies in Childhood (ISAAC) phase three. Thorax 2013; 68(4): 351-60.
    • 58. Gotshall RW, Mickleborough TD, Cordain L. Dietary salt restriction improves pulmonary function in exercise-induced asthma. Med Sci Sports Exerc 2000; 32(11): 1815-9.
    • 59. Kocyigit A, Armutcu F, Gurel A, Ermis B. Alterations in plasma essential trace elements selenium, manganese, zinc, copper, and iron concentrations and the possible role of these elements on oxidative status in patients with childhood asthma. Biological trace element research 2004; 97(1): 31-41.
    • 60. Allen S, Britton JR, Leonardi-Bee JA. Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis. Thorax 2009; 64(7): 610-9.
    • 61. Troisi RJ, Willett WC, Weiss ST, Trichopoulos D, Rosner B, Speizer FE. A prospective study of diet and adult-onset asthma. Am J Respir Crit Care Med 1995; 151(5): 1401-8.
    • 62. Sin DD, Sutherland ER. Obesity and the lung: 4. Obesity and asthma. Thorax 2008; 63(11): 1018-23.
    • 63. Schwartz J, Slater D, Larson TV, Pierson WE, Koenig JQ. Particulate air pollution and hospital emergency room visits for asthma in Seattle. Am Rev Respir Dis 1993; 147(4): 826-31.
    • 64. MAGAZINE BETE. EarthTalk: Is U.S. air quality getting better or worse? 2013. http://www.lung.org/associations/states/florida/news/top-story-in-thenews/earthtalk-is-us-air.html2014).
    • 65. Lomborg b. Take a deep breath... air quality is getting better. 2001. http://www.theguardian.com/environment/2001/aug/15/physicalsciences.globalwa rming2014).
    • 66. Plumer b. Air pollution now kills more people than high cholesterol. 2012. http://www.washingtonpost.com/blogs/wonkblog/wp/2012/12/20/air-pollutionnow-kills-more-people-than-high-cholesterol/2014).
    • 67. Law BJ, Carbonell-Estrany X, Simoes EAF. An update on respiratory syncytial virus epidemiology: a developed country perspective. Respiratory Medicine 2002; 96, Supplement 2(0): S1-S7.
    • 68. Henderson J, Hilliard TN, Sherriff A, Stalker D, Al Shammari N, Thomas HM. Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatr Allergy Immunol 2005; 16(5): 386-92.
    • 69. Stein RT, Sherrill D, Morgan WJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999; 354(9178): 541-5.
    • 70. Sigurs N, Aljassim F, Kjellman B, et al. Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax 2010; 65(12): 1045-52.
    • 71. Stensballe LG, Simonsen JB, Thomsen SF, et al. The causal direction in the association between respiratory syncytial virus hospitalization and asthma. J Allergy Clin Immunol 2009; 123(1): 131-7 e1.
    • 72. Blanken MO, Rovers MM, Molenaar JM, et al. Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N Engl J Med 2013; 368(19): 1791-9.
    • 73. Kerkhof M, Wijga AH, Brunekreef B, et al. Effects of pets on asthma development up to 8 years of age: the PIAMA study. Allergy 2009; 64(8): 1202-8.
    • 74. Taussig LM, Wright AL, Morgan WJ, Harrison HR, Ray CG. The Tucson Children's Respiratory Study. I. Design and implementation of a prospective study of acute and chronic respiratory illness in children. Am J Epidemiol 1989; 129(6): 1219- 31.
    • 75. Sears MR, Greene JM, Willan AR, et al. Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study. Lancet 2002; 360(9337): 901-7.
    • 76. Henderson J, Granell R, Heron J, et al. Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in midchildhood. Thorax 2008; 63(11): 974-80.
    • 77. Lowe AJ, Carlin JB, Bennett CM, et al. Atopic disease and breast-feeding-- cause or consequence? J Allergy Clin Immunol 2006; 117(3): 682-7.
    • 78. Henderson AJ. What have we learned from prospective cohort studies of asthma in children? Chronic respiratory disease 2008; 5(4): 225-31.
    • 79. Burgess JA, Dharmage SC, Byrnes GB, et al. Childhood eczema and asthma incidence and persistence: a cohort study from childhood to middle age. J Allergy Clin Immunol 2008; 122(2): 280-5.
    • 80. Rasmussen F, Taylor DR, Flannery EM, et al. Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1/vital capacity ratio: a longitudinal population study from childhood to adulthood. Am J Respir Crit Care Med 2002; 165(11): 1480-8.
    • 81. Wright AL, Holberg CJ, Taussig LM, Martinez FD. Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhood. Thorax 2001; 56(3): 192-7.
    • 82. Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 2000; 343(8): 538-43.
    • 83. Lau S, Illi S, Sommerfeld C, et al. Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study Group. Lancet 2000; 356(9239): 1392-7.
    • 84. Illi S, von Mutius E, Lau S, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004; 113(5): 925-31.
    • 85. Illi S, von Mutius E, Lau S, et al. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ 2001; 322(7283): 390-5.
    • 86. Shaheen SO, Newson RB, Sherriff A, et al. Paracetamol use in pregnancy and wheezing in early childhood. Thorax 2002; 57(11): 958-63.
    • 87. Elliott L, Henderson J, Northstone K, Chiu GY, Dunson D, London SJ. Prospective study of breast-feeding in relation to wheeze, atopy, and bronchial hyperresponsiveness in the Avon Longitudinal Study of Parents and Children (ALSPAC). J Allergy Clin Immunol 2008; 122(1): 49-54, e1-3.
    • 88. Maitra A, Sherriff A, Strachan D, Henderson J. Mode of delivery is not associated with asthma or atopy in childhood. Clin Exp Allergy 2004; 34(9): 1349-55.
    • 89. Simpson A, Tan VY, Winn J, et al. Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am J Respir Crit Care Med 2010; 181(11): 1200-6.
    • 90. Scholtens S, Wijga AH, Brunekreef B, et al. Breast feeding, parental allergy and asthma in children followed for 8 years. The PIAMA birth cohort study. Thorax 2009; 64(7): 604-9.
    • 91. Wijga AH, Smit HA, Kerkhof M, et al. Association of consumption of products containing milk fat with reduced asthma risk in pre-school children: the PIAMA birth cohort study. Thorax 2003; 58(7): 567-72.
    • 92. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332(3): 133-8.
    • 93. Sherriff A, Peters TJ, Henderson J, Strachan D, Parents ASTALSo, Children. Risk factor associations with wheezing patterns in children followed longitudinally from birth to 3(1/2) years. Int J Epidemiol 2001; 30(6): 1473-84.
    • 94. Edwards CA, Osman LM, Godden DJ, Douglas JG. Wheezy bronchitis in childhood: a distinct clinical entity with lifelong significance? Chest 2003; 124(1): 18- 24.
    • 95. Mai XM, Almqvist C, Nilsson L, Wickman M. Birth anthropometric measures, body mass index and allergic diseases in a birth cohort study (BAMSE). Arch Dis Child 2007; 92(10): 881-6.
    • 96. Lau S, Illi S, Sommerfeld C, et al. Transient early wheeze is not associated with impaired lung function in 7-yr-old children. Eur Respir J 2003; 21(5): 834-41.
    • 97. Sandin A, Bjorksten B, Braback L. Development of atopy and wheezing symptoms in relation to heredity and early pet keeping in a Swedish birth cohort. Pediatr Allergy Immunol 2004; 15(4): 316-22.
    • 98. Lowe LA, Simpson A, Woodcock A, et al. Wheeze phenotypes and lung function in preschool children. Am J Respir Crit Care Med 2005; 171(3): 231-7.
    • 99. Rusconi F, Galassi C, Corbo GM, et al. Risk factors for early, persistent, and late-onset wheezing in young children. SIDRIA Collaborative Group. Am J Respir Crit Care Med 1999; 160(5 Pt 1): 1617-22.
    • 100. Merrett TG, Burr ML, Butland BK, Merrett J, Miskelly FG, Vaughan-Williams E. Infant feeding and allergy: 12-month prospective study of 500 babies born into allergic families. Ann Allergy 1988; 61(6 Pt 2): 13-20.
    • 101. Tariq SM, Matthews SM, Hakim EA, Stevens M, Arshad SH, Hide DW. The prevalence of and risk factors for atopy in early childhood: a whole population birth cohort study. J Allergy Clin Immunol 1998; 101(5): 587-93.
    • 102. Basagana X, Sunyer J, Kogevinas M, et al. Socioeconomic status and asthma prevalence in young adults: the European Community Respiratory Health Survey. Am J Epidemiol 2004; 160(2): 178-88.
    • 103. Poyser MA, Nelson H, Ehrlich RI, et al. Socioeconomic deprivation and asthma prevalence and severity in young adolescents. Eur Respir J 2002; 19(5): 892- 8.
    • 104. Miskelly FG, Burr ML, Vaughan-Williams E, Fehily AM, Butland BK, Merrett TG. Infant feeding and allergy. Arch Dis Child 1988; 63(4): 388-93.
    • 105. Burr ML, Miskelly FG, Butland BK, Merrett TG, Vaughan-Williams E. Environmental factors and symptoms in infants at high risk of allergy. J Epidemiol Community Health 1989; 43(2): 125-32.
    • 106. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993; 16: 5-40.
    • 107. Burr ML, Limb ES, Maguire MJ, et al. Infant feeding, wheezing, and allergy: a prospective study. Arch Dis Child 1993; 68(6): 724-8.
    • 108. Lowe GL, Burr M. Undiagnosed and untreated wheezing in a cohort of adolescents with a family history of allergic disease. Br J Gen Pract 2001; 51(469): 664-5.
    • 109. Asher MI, Keil U, Anderson HR, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 1995; 8(3): 483- 91.
    • 110. ISAAC. International study of asthma and allergy in childhood. Phase one manual. 1993
    • 111. Berger A. Skin prick testing. BMJ 2002; 325(7361): 414.
    • 112. McGowan EM, Saad S, Bendall LJ, Bradstock KF, Clarke CL. Effect of progesterone receptor a predominance on breast cancer cell migration into bone marrow fibroblasts. Breast Cancer Res Treat 2004; 83(3): 211-20.
    • 113. Lundh A, Gotzsche PC. Recommendations by Cochrane Review Groups for assessment of the risk of bias in studies. BMC Med Res Methodol 2008; 8: 22.
    • 114. Altman DG. Statistics in medical journals: some recent trends. Stat Med 2000; 19(23): 3275-89.
    • 115. Johnston ID, Strachan DP, Anderson HR. Effect of pneumonia and whooping cough in childhood on adult lung function. N Engl J Med 1998; 338(9): 581-7.
    • 116. Sears MR, Greene JM, Willan AR, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003; 349(15): 1414-22.
    • 117. Stern DA, Morgan WJ, Halonen M, Wright AL, Martinez FD. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet 2008; 372(9643): 1058-64.
    • 118. Fewtrell MS, Kennedy K, Singhal A, et al. How much loss to follow-up is acceptable in long-term randomised trials and prospective studies? Arch Dis Child 2008; 93(6): 458-61.
    • 119. Drivsholm T, Eplov LF, Davidsen M, et al. Representativeness in populationbased studies: a detailed description of non-response in a Danish cohort study. Scand J Public Health 2006; 34(6): 623-31.
    • 120. Knudsen AK, Hotopf M, Skogen JC, Overland S, Mykletun A. The health status of nonparticipants in a population-based health study: the Hordaland Health Study. Am J Epidemiol 2010; 172(11): 1306-14.
    • 121. Harald K, Salomaa V, Jousilahti P, Koskinen S, Vartiainen E. Non-participation and mortality in different socioeconomic groups: the FINRISK population surveys in 1972-92. J Epidemiol Community Health 2007; 61(5): 449-54.
    • 122. Bergmann RL, Edenharter G, Bergmann KE, Lau S, Wahn U. Socioeconomic status is a risk factor for allergy in parents but not in their children. Clin Exp Allergy 2000; 30(12): 1740-5.
    • 123. Bousquet J, Chanez P, Lacoste JY, et al. Asthma: a disease remodeling the airways. Allergy 1992; 47(1): 3-11.
    • 124. Security. DoHaS. Inequalities in health: report of a research working group. . London: DHSS, 1980 1980.
    • 125. Shohaimi S, Welch A, Bingham S, et al. Area deprivation predicts lung function independently of education and social class. Eur Respir J 2004; 24(1): 157- 61.
    • 126. Williams HC, Strachan DP, Hay RJ. Childhood eczema: disease of the advantaged? BMJ 1994; 308(6937): 1132-5.
    • 127. Bugiani M, Carosso A, Migliore E, et al. Allergic rhinitis and asthma comorbidity in a survey of young adults in Italy. Allergy 2005; 60(2): 165-70.
    • 128. Strachan DP, Harkins LS, Johnston ID, Anderson HR. Childhood antecedents of allergic sensitization in young British adults. J Allergy Clin Immunol 1997; 99(1 Pt 1): 6-12.
    • 129. Strachan DP, Anderson HR, Limb ES, O'Neill A, Wells N. A national survey of asthma prevalence, severity, and treatment in Great Britain. Arch Dis Child 1994; 70(3): 174-8.
    • 130. Baker D, Henderson J. Differences between infants and adults in the social aetiology of wheeze. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. J Epidemiol Community Health 1999; 53(10): 636-42.
    • 131. Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014; 43(2): 343- 73.
    • 132. Braback L, Hjern A, Rasmussen F. Social class in asthma and allergic rhinitis: a national cohort study over three decades. Eur Respir J 2005; 26(6): 1064-8.
    • 133. Rona RJ, Hughes JM, Chinn S. Association between asthma and family size between 1977 and 1994. J Epidemiol Community Health 1999; 53(1): 15-9.
    • 134. Mitchell EA, Beasley R, Bjorksten B, et al. The association between BMI, vigorous physical activity and television viewing and the risk of symptoms of asthma, rhinoconjunctivitis and eczema in children and adolescents: ISAAC Phase Three. Clin Exp Allergy 2013; 43(1): 73-84.
    • 135. Portsmouth GHGUo. Liverpool through time | Historical Statistics on Social Structure for the District/Unitary Authority | Rate: Percentage of Working-Age Males in Class 1 & 2, A Vision of Britain through Time. 2014. http://www.visionofbritain.org.uk/unit/10105821/rate/RGSOC_12 (accessed Date accessed: 08th April 2014.
    • 136. tradingeconomics. british unemployment rates. 2013. http://www.tradingeconomics.com/united-kingdom/unemployment-rate 137. Holloway JW, Beghe B, Holgate ST. The genetic basis of atopic asthma. Clin Exp Allergy 1999; 29(8): 1023-32.
    • 138. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008; 8(3): 169-82.
    • 139. Kumar A, Ghosh B. Genetics of asthma: a molecular biologist perspective. Clin Mol Allergy 2009; 7: 7.
    • 140. Burke W, Fesinmeyer M, Reed K, Hampson L, Carlsten C. Family history as a predictor of asthma risk. Am J Prev Med 2003; 24(2): 160-9.
    • 141. Sarafino EP. Connections among parent and child atopic illnesses. Pediatr Allergy Immunol 2000; 11(2): 80-6.
    • 142. Duffy DL, Martin NG, Battistutta D, Hopper JL, Mathews JD. Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis 1990; 142(6 Pt 1): 1351- 8.
    • 143. Los H, Postmus PE, Boomsma DI. Asthma genetics and intermediate phenotypes: a review from twin studies. Twin Res 2001; 4(2): 81-93.
    • 144. Litonjua AA, Carey VJ, Burge HA, Weiss ST, Gold DR. Parental history and the risk for childhood asthma. Does mother confer more risk than father? Am J Respir Crit Care Med 1998; 158(1): 176-81.
    • 145. Alford SH, Zoratti E, Peterson EL, Maliarik M, Ownby DR, Johnson CC. Parental history of atopic disease: disease pattern and risk of pediatric atopy in offspring. J Allergy Clin Immunol 2004; 114(5): 1046-50.
    • 146. Jenkins MA, Hopper JL, Bowes G, Carlin JB, Flander LB, Giles GG. Factors in childhood as predictors of asthma in adult life. BMJ 1994; 309(6947): 90-3.
    • 147. Dold S, Wjst M, von Mutius E, Reitmeir P, Stiepel E. Genetic risk for asthma, allergic rhinitis, and atopic dermatitis. Arch Dis Child 1992; 67(8): 1018-22.
    • 148. Patino CM, Martinez FD. Interactions between genes and environment in the development of asthma. Allergy 2001; 56(4): 279-86.
    • 149. Somerville SM, Rona RJ, Chinn S. Obesity and respiratory symptoms in primary school. Arch Dis Child 1984; 59(10): 940-4.
    • 150. Ford ES. The epidemiology of obesity and asthma. J Allergy Clin Immunol 2005; 115(5): 897-909; quiz 10.
    • 151. Rodriguez MA, Winkleby MA, Ahn D, Sundquist J, Kraemer HC. Identification of population subgroups of children and adolescents with high asthma prevalence: findings from the Third National Health and Nutrition Examination Survey. Arch Pediatr Adolesc Med 2002; 156(3): 269-75.
    • 152. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000; 320(7244): 1240-3.
    • 153. Chinn S, Jarvis D, Burney P, European Community Respiratory Health S. Relation of bronchial responsiveness to body mass index in the ECRHS. European Community Respiratory Health Survey. Thorax 2002; 57(12): 1028-33.
    • 154. Shaheen SO, Sterne JA, Montgomery SM, Azima H. Birth weight, body mass index and asthma in young adults. Thorax 1999; 54(5): 396-402.
    • 155. Murray CS, Canoy D, Buchan I, Woodcock A, Simpson A, Custovic A. Body mass index in young children and allergic disease: gender differences in a longitudinal study. Clin Exp Allergy 2011; 41(1): 78-85.
    • 156. Litonjua AA, Sparrow D, Celedon JC, DeMolles D, Weiss ST. Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study. Thorax 2002; 57(7): 581-5.
    • 157. Celedon JC, Palmer LJ, Litonjua AA, et al. Body mass index and asthma in adults in families of subjects with asthma in Anqing, China. Am J Respir Crit Care Med 2001; 164(10 Pt 1): 1835-40.
    • 158. Delgado J, Barranco P, Quirce S. Obesity and asthma. J Investig Allergol Clin Immunol 2008; 18(6): 420-5.
    • 159. Group TES. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Respiratory Journal 2003; 22(3): 470-7.
    • 160. Mosen DM, Schatz M, Magid DJ, Camargo CA, Jr. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol 2008; 122(3): 507-11 e6.
    • 161. Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010; 181(4): 315-23.
    • 162. Dixon JB, Chapman L, O'Brien P. Marked improvement in asthma after LapBand surgery for morbid obesity. Obes Surg 1999; 9(4): 385-9.
    • 163. Schmidt ME, Steindorf K. Statistical methods for the validation of questionnaires--discrepancy between theory and practice. Methods Inf Med 2006; 45(4): 409-13.
    • 164. Korkeila K, Suominen S, Ahvenainen J, et al. Non-response and related factors in a nation-wide health survey. Eur J Epidemiol 2001; 17(11): 991-9.
    • 165. Martin PE, Matheson MC, Gurrin L, et al. Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: a prospective cohort study over 4 decades. J Allergy Clin Immunol 2011; 127(6): 1473-9 e1.
    • 166. Punekar YS, Sheikh A. Establishing the sequential progression of multiple allergic diagnoses in a UK birth cohort using the General Practice Research Database. Clin Exp Allergy 2009; 39(12): 1889-95.
    • 167. Davies H, Joshi, H, Clarke, L. Is it cash that the deprived are short of? Journal of the Royal Statistical Society 1997; 160 (1): 107-26.
    • 168. Chen Y, Dales R, Krewski D, Breithaupt K. Increased effects of smoking and obesity on asthma among female Canadians: the National Population Health Survey, 1994-1995. Am J Epidemiol 1999; 150(3): 255-62.
    • 169. Castro-Rodriguez JA, Holberg CJ, Morgan WJ, Wright AL, Martinez FD. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med 2001; 163(6): 1344-9.
    • 170. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444(7121): 860-7.
    • 171. Boulet LP. Obesity and atopy. Clinical & Experimental Allergy 2015; 45(1): 75-86.
    • 172. Appleton SL, Adams RJ, Wilson DH, Taylor AW, Ruffin RE. Central obesity is associated with nonatopic but not atopic asthma in a representative population sample. Journal of Allergy and Clinical Immunology; 118(6): 1284-91.
    • 173. Mead J. Dysanapsis in normal lungs assessed by the relationship between maximal flow, static recoil, and vital capacity. Am Rev Respir Dis 1980; 121(2): 339- 42.
    • 174. Wheeldon NM, Newnham DM, Coutie WJ, Peters JA, McDevitt DG, Lipworth BJ. Influence of sex-steroid hormones on the regulation of lymphocyte beta 2- adrenoceptors during the menstrual cycle. British journal of clinical pharmacology 1994; 37(6): 583-8.
    • 175. PASQUALI R, ANTENUCCI D, CASIMIRRI F, et al. Clinical and Hormonal Characteristics of Obese Amenorrheic Hyperandrogenic Women Before and After Weight Loss. The Journal of Clinical Endocrinology & Metabolism 1989; 68(1): 173-9.
    • 176. Delacourt C, Labbe D, Vassault A, Brunet-Langot D, de Blic J, Scheinmann P. Sensitization to inhalant allergens in wheezing infants is predictive of the development of infantile asthma. Allergy 1994; 49(10): 843-7.
    • 177. Hammad H, Lambrecht BN. Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation. J Allergy Clin Immunol 2006; 118(2): 331-6.
    • 178. Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 2008; 8(3): 183-92.
    • 179. Deamer WC. Asthma and mites: An early theory. Journal of Allergy and Clinical Immunology 1971; 48(4): 251-2.
    • 180. Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med 1990; 323(8): 502-7.
    • 181. Sherrill D, Stein R, Kurzius-Spencer M, Martinez F. On early sensitization to allergens and development of respiratory symptoms. Clin Exp Allergy 1999; 29(7): 905-11.
    • 182. Illi S, von Mutius E, Lau S, et al. The pattern of atopic sensitization is associated with the development of asthma in childhood. J Allergy Clin Immunol 2001; 108(5): 709-14.
    • 183. Kulig M, Bergmann R, Tacke U, Wahn U, Guggenmoos-Holzmann I. Longlasting sensitization to food during the first two years precedes allergic airway disease. The MAS Study Group, Germany. Pediatr Allergy Immunol 1998; 9(2): 61-7.
    • 184. Lazic N, Roberts G, Custovic A, et al. Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts. Allergy 2013; 68(6): 764-70.
    • 185. Morgan WJ, Stern DA, Sherrill DL, et al. Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. Am J Respir Crit Care Med 2005; 172(10): 1253-8.
    • 186. Haahtela T, Bjorksten F, Heiskala M, Suoniemi I. Skin prick test reactivity to common allergens in Finnish adolescents. Allergy 1980; 35(5): 425-31.
    • 187. de Jong AB, Dikkeschei LD, Brand PL. Sensitization patterns to food and inhalant allergens in childhood: a comparison of non-sensitized, monosensitized, and polysensitized children. Pediatr Allergy Immunol 2011; 22(2): 166-71.
    • 188. Gergen PJT, Turkeltaub PC. P. C. Prevalence of Percutaneous Immediate Hypersensitivity and Histamine Reactivity in the U. S. Population: Data from the Second National Health and Nutrition Examination Survey. . In: Marsh DG B, M. N., editor. , ed. Genetic and environmental factors in clinical allergy: minnesota; 1990.
    • 189. Gergen PJT, P. C. Prevalence of Percutaneous Immediate Hypersensitivity and Histamine Reactivity in the U. S. Population: Data from the Second National Health and Nutrition Examination Survey. In: Marsh DG, Blumenthal, M. N., ed. Genetic and environmental factors in clinical allergy minnesota; 1990.
    • 190. Arbes SJ, Jr., Gergen PJ, Elliott L, Zeldin DC. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy Clin Immunol 2005; 116(2): 377-83.
    • 191. Barbee RA, Kaltenborn W, Lebowitz MD, Burrows B. Longitudinal changes in allergen skin test reactivity in a community population sample. J Allergy Clin Immunol 1987; 79(1): 16-24.
    • 192. Broadfield E, McKeever TM, Scrivener S, Venn A, Lewis SA, Britton J. Increase in the prevalence of allergen skin sensitization in successive birth cohorts. J Allergy Clin Immunol 2002; 109(6): 969-74.
    • 193. Stern DA, Lohman IC, Wright AL, Taussig LM, Martinez FD, Halonen M. Dynamic changes in sensitization to specific aeroallergens in children raised in a desert environment. Clin Exp Allergy 2004; 34(10): 1563-669.
    • 194. Asarnoj A, Ostblom E, Kull I, et al. Sensitization to inhalant allergens between 4 and 8 years of age is a dynamic process: results from the BAMSE birth cohort. Clin Exp Allergy 2008; 38(9): 1507-13.
    • 195. Burney P, Malmberg E, Chinn S, Jarvis D, Luczynska C, Lai E. The distribution of total and specific serum IgE in the European Community Respiratory Health Survey. J Allergy Clin Immunol 1997; 99(3): 314-22.
    • 196. Janson C, Anto J, Burney P, et al. The European Community Respiratory Health Survey: what are the main results so far? European Community Respiratory Health Survey II. Eur Respir J 2001; 18(3): 598-611.
    • 197. Leynaert B, Neukirch C, Jarvis D, et al. Does living on a farm during childhood protect against asthma, allergic rhinitis, and atopy in adulthood? Am J Respir Crit Care Med 2001; 164(10 Pt 1): 1829-34.
    • 198. Chan-Yeung M, Anthonisen NR, Becklake MR, et al. Geographical variations in the prevalence of atopic sensitization in six study sites across Canada. Allergy 2010; 65(11): 1404-13.
    • 199. Aslund N, Thomsen SF, Molgaard E, Nolte H, Backer V. Changes in skin test reactivity among adults with atopic disease: a 3-year prospective study. Ann Allergy Asthma Immunol 2008; 101(5): 524-8.
    • 200. Bodtger U, Linneberg A. Remission of allergic rhinitis: An 8-year observational study. J Allergy Clin Immunol 2004; 114(6): 1384-8.
    • 201. Matricardi PM, Bockelbrink A, Keil T, et al. Dynamic evolution of serum immunoglobulin E to airborne allergens throughout childhood: results from the Multi-Centre Allergy Study birth cohort. Clin Exp Allergy 2009; 39(10): 1551-7.
    • 202. Wahn U, Lau S, Bergmann R, et al. Indoor allergen exposure is a risk factor for sensitization during the first three years of life. J Allergy Clin Immunol 1997; 99(6 Pt 1): 763-9.
    • 203. Woodcock A, Lowe LA, Murray CS, et al. Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med 2004; 170(4): 433-9.
    • 204. Brown WG, Halonen MJ, Kaltenborn WT, Barbee RA. The relationship of respiratory allergy, skin test reactivity, and serum IgE in a community population sample. J Allergy Clin Immunol 1979; 63(5): 328-35.
    • 205. Klink M, Cline MG, Halonen M, Burrows B. Problems in defining normal limits for serum IgE. J Allergy Clin Immunol 1990; 85(2): 440-4.
    • 206. Sears MR, Burrows B, Flannery EM, Herbison GP, Hewitt CJ, Holdaway MD. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 1991; 325(15): 1067-71.
    • 207. Sunyer J, Anto JM, Castellsague J, Soriano JB, Roca J. Total serum IgE is associated with asthma independently of specific IgE levels. The Spanish Group of the European Study of Asthma. Eur Respir J 1996; 9(9): 1880-4.
    • 208. Sunyer J, Antó JM, Sabrià J, et al. Relationship between serum IgE and airway responsiveness in adults with asthma. Journal of Allergy and Clinical Immunology 1995; 95(3): 699-706.
    • 209. Brunekreef B, Smit J, de Jongste J, et al. The prevention and incidence of asthma and mite allergy (PIAMA) birth cohort study: design and first results. Pediatr Allergy Immunol 2002; 13 Suppl 15: 55-60.
    • 210. Custovic A, Simpson BM, Murray CS, Lowe L, Woodcock A. The National Asthma Campaign Manchester Asthma and Allergy Study. Pediatr Allergy Immunol 2002; 13 Suppl 15: 32-7.
    • 211. Corver K, Kerkhof M, Brussee JE, et al. House dust mite allergen reduction and allergy at 4 yr: follow up of the PIAMA-study. Pediatr Allergy Immunol 2006; 17(5): 329-36.
    • 212. Scott M, Roberts G, Kurukulaaratchy RJ, Matthews S, Nove A, Arshad SH. Multifaceted allergen avoidance during infancy reduces asthma during childhood with the effect persisting until age 18 years. Thorax 2012; 67(12): 1046-51.
    • 213. Cline MG, Burrows B. Distribution of allergy in a population sample residing in Tucson, Arizona. Thorax 1989; 44(5): 425-31.
    • 214. Perkins NJ, Schisterman EF, Vexler A. Receiver operating characteristic curve inference from a sample with a limit of detection. Am J Epidemiol 2007; 165(3): 325- 33.
    • 215. Bewick V, Cheek L, Ball J. Statistics review 13: receiver operating characteristic curves. Crit Care 2004; 8(6): 508-12.
    • 216. Roberts G, Zhang H, Karmaus W, et al. Trends in cutaneous sensitization in the first 18 years of life: results from the 1989 Isle of Wight birth cohort study. Clin Exp Allergy 2012; 42(10): 1501-9.
    • 217. Holt PG. Immunoprophylaxis of atopy: light at the end of the tunnel? Immunol Today 1994; 15(10): 484-9.
    • 218. Nilsson L, Bjorksten B, Hattevig G, Kjellman B, Sigurs N, Kjellman NI. Season of birth as predictor of atopic manifestations. Arch Dis Child 1997; 76(4): 341-4.
    • 219. Oryszczyn MP, Annesi I, Neukirch F, Doré MF, Kauffmann F. Longitudinal observations of serum IgE and skin prick test response. American Journal of Respiratory and Critical Care Medicine 1995; 151(3): 663-8.
    • 220. Matricardi PM, Bockelbrink A, Gruber C, et al. Longitudinal trends of total and allergen-specific IgE throughout childhood. Allergy 2009; 64(7): 1093-8.
    • 221. Kurukulaaratchy RJ, Fenn M, Matthews S, Arshad SH. Characterisation of atopic and non-atopic wheeze in 10 year old children. Thorax 2004; 59(7): 563-8.
    • 222. Garcia-Marcos L, Castro-Rodriguez JA, Suarez-Varela MM, et al. A different pattern of risk factors for atopic and non-atopic wheezing in 9-12-year-old children. Pediatr Allergy Immunol 2005; 16(6): 471-7.
    • 223. Gergen PJ, Turkeltaub PC, Kovar MG. The prevalence of allergic skin test reactivity to eight common aeroallergens in the U.S. population: results from the second National Health and Nutrition Examination Survey. J Allergy Clin Immunol 1987; 80(5): 669-79.
    • 224. Douwes J, Gibson P, Pekkanen J, Pearce N. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002; 57(7): 643-8.
    • 225. Burrows B, Martinez FD, Cline MG, Lebowitz MD. The relationship between parental and children's serum IgE and asthma. Am J Respir Crit Care Med 1995; 152(5 Pt 1): 1497-500.
    • 226. Morahan G, Huang D, Wu M, et al. Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet 2002; 360(9331): 455-9.
    • 227. Holgate ST, Djukanovic R, Casale T, Bousquet J. Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy. Clin Exp Allergy 2005; 35(4): 408-16.
    • 228. Custovic A. To what extent is allergen exposure a risk factor for the development of allergic disease? Clin Exp Allergy 2015; 45(1): 54-62.
    • 229. Sunyer J, Jarvis D, Pekkanen J, et al. Geographic variations in the effect of atopy on asthma in the European Community Respiratory Health Study. J Allergy Clin Immunol 2004; 114(5): 1033-9.
    • 230. Weinmayr G, Weiland SK, Bjorksten B, et al. Atopic sensitization and the international variation of asthma symptom prevalence in children. Am J Respir Crit Care Med 2007; 176(6): 565-74.
    • 231. Ring J, Brockow K, Abeck D. The therapeutic concept of "patient management" in atopic eczema. Allergy 1996; 51(4): 206-15.
    • 232. Host A. Frequency of cow's milk allergy in childhood. Ann Allergy Asthma Immunol 2002; 89(6 Suppl 1): 33-7.
    • 233. Lucas A, Brooke OG, Morley R, Cole TJ, Bamford MF. Early diet of preterm infants and development of allergic or atopic disease: randomised prospective study. BMJ 1990; 300(6728): 837-40.
    • 234. Host A, Husby S, Osterballe O. A prospective study of cow's milk allergy in exclusively breast-fed infants. Incidence, pathogenetic role of early inadvertent exposure to cow's milk formula, and characterization of bovine milk protein in human milk. Acta Paediatr Scand 1988; 77(5): 663-70.
    • 235. Sinn J, Osborn DA. Primary prevention with hydrolysed formula: does it change natural onset of allergic disease? Clin Exp Allergy 2010; 40(4): 534-5.
    • 236. Kramer MS. Does breast feeding help protect against atopic disease? Biology, methodology, and a golden jubilee of controversy. J Pediatr 1988; 112(2): 181-90.
    • 237. Zeiger RS. Dietary manipulations in infants and their mothers and the natural course of atopic disease. Pediatr Allergy Immunol 1994; 5(6 Suppl): 33-43.
    • 238. de Jong MH, Scharp-Van Der Linden VT, Aalberse R, Heymans HS, Brunekreef B. The effect of brief neonatal exposure to cows' milk on atopic symptoms up to age 5. Arch Dis Child 2002; 86(5): 365-9.
    • 239. Matheson MC, Erbas B, Balasuriya A, et al. Breast-feeding and atopic disease: a cohort study from childhood to middle age. J Allergy Clin Immunol 2007; 120(5): 1051-7.
    • 240. Kull I, Almqvist C, Lilja G, Pershagen G, Wickman M. Breast-feeding reduces the risk of asthma during the first 4 years of life. J Allergy Clin Immunol 2004; 114(4): 755-60.
    • 241. Oddy WH, Peat JK, de Klerk NH. Maternal asthma, infant feeding, and the risk of asthma in childhood. J Allergy Clin Immunol 2002; 110(1): 65-7.
    • 242. Mihrshahi S, Ampon R, Webb K, et al. The association between infant feeding practices and subsequent atopy among children with a family history of asthma. Clin Exp Allergy 2007; 37(5): 671-9.
    • 243. Saarinen UM, Kajosaari M. Breastfeeding as prophylaxis against atopic disease: prospective follow-up study until 17 years old. Lancet 1995; 346(8982): 1065-9.
    • 244. Zutavern A, von Mutius E, Harris J, et al. The introduction of solids in relation to asthma and eczema. Arch Dis Child 2004; 89(4): 303-8.
    • 245. Hanson LA, Soderstrom T. Human milk: Defense against infection. Prog Clin Biol Res 1981; 61: 147-59.
    • 246. Prescott SL, Macaubas C, Holt BJ, et al. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 1998; 160(10): 4730-7.
    • 247. Halpern SR, Sellars WA, Johnson RB, Anderson DW, Saperstein S, Reisch JS. Development of childhood allergy in infants fed breast, soy, or cow milk. J Allergy Clin Immunol 1973; 51(3): 139-51.
    • 248. Johnstone DE, Dutton AM. Dietary prophylaxis of allergic disease in children. N Engl J Med 1966; 274(13): 715-9.
    • 249. Lowe AJ, Hosking CS, Bennett CM, et al. Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: a randomized controlled trial. J Allergy Clin Immunol 2011; 128(2): 360-5 e4.
    • 250. Berg A, Kramer U, Link E, et al. Impact of early feeding on childhood eczema: development after nutritional intervention compared with the natural course - the GINIplus study up to the age of 6 years. Clin Exp Allergy 2010; 40(4): 627-36.
    • 251. Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 1997; 159(4): 1739-45.
    • 252. Adkins B, Bu Y, Cepero E, Perez R. Exclusive Th2 primary effector function in spleens but mixed Th1/Th2 function in lymph nodes of murine neonates. J Immunol 2000; 164(5): 2347-53.
    • 253. Wickens KL, Crane J, Kemp TJ, et al. Family size, infections, and asthma prevalence in New Zealand children. Epidemiology 1999; 10(6): 699-705.
    • 254. Remes ST, Castro-Rodriguez JA, Holberg CJ, Martinez FD, Wright AL. Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. J Allergy Clin Immunol 2001; 108(4): 509-15.
    • 255. Kim JH, Ellwood PE, Asher MI. Diet and asthma: looking back, moving forward. Respir Res 2009; 10: 49.
    • 256. Becklake MR, Ernst P. Environmental factors. Lancet 1997; 350 Suppl 2: SII10-3.
    • 257. Miller RL, Ho SM. Environmental epigenetics and asthma: current concepts and call for studies. Am J Respir Crit Care Med 2008; 177(6): 567-73.
    • 258. Smith JM, Harding LK, Cumming G. The changing prevalence of asthma in school children. Clinical & Experimental Allergy 1971; 1(1): 57-61.
    • 259. Gregg I, editor. Epidemiological aspects Second ed: Chapman and Hall;; 1983.
    • 260. Kuehni CE, Strippoli MP, Low N, Silverman M. Asthma in young south Asian women living in the United Kingdom: the importance of early life. Clin Exp Allergy 2007; 37(1): 47-53.
    • 261. von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell G, Thiemann HH. Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med 1994; 149(2 Pt 1): 358-64.
    • 262. Frye C, Heinrich J, Wjst M, Wichmann HE, Bitterfeld Study G. Increasing prevalence of bronchial hyperresponsiveness in three selected areas in East Germany. Bitterfeld Study Group. Eur Respir J 2001; 18(3): 451-8.
    • 263. Waser M, Schierl R, von Mutius E, et al. Determinants of endotoxin levels in living environments of farmers' children and their peers from rural areas. Clin Exp Allergy 2004; 34(3): 389-97.
    • 264. Heinrich J, Gehring U, Douwes J, et al. Pets and vermin are associated with high endotoxin levels in house dust. Clin Exp Allergy 2001; 31(12): 1839-45.
    • 265. Doreswamy V, Peden DB. Modulation of asthma by endotoxin. Clin Exp Allergy 2011; 41(1): 9-19.
    • 266. Riedler J, Braun-Fahrlander C, Eder W, et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358(9288): 1129-33.
    • 267. Gehring U, Strikwold M, Schram-Bijkerk D, et al. Asthma and allergic symptoms in relation to house dust endotoxin: Phase Two of the International Study on Asthma and Allergies in Childhood (ISAAC II). Clin Exp Allergy 2008; 38(12): 1911- 20.
    • 268. Munir AK, Bjorksten B, Einarsson R, et al. Cat (Fel d I), dog (Can f I), and cockroach allergens in homes of asthmatic children from three climatic zones in Sweden. Allergy 1994; 49(7): 508-16.
    • 269. Perzanowski MS, Ronmark E, Platts-Mills TA, Lundback B. Effect of cat and dog ownership on sensitization and development of asthma among preteenage children. Am J Respir Crit Care Med 2002; 166(5): 696-702.
    • 270. de Marco R, Pattaro C, Locatelli F, Svanes C, Group ES. Influence of early life exposures on incidence and remission of asthma throughout life. J Allergy Clin Immunol 2004; 113(5): 845-52.
    • 271. Svanes C, Heinrich J, Jarvis D, et al. Pet-keeping in childhood and adult asthma and hay fever: European community respiratory health survey. J Allergy Clin Immunol 2003; 112(2): 289-300.
    • 272. Apelberg BJ, Aoki Y, Jaakkola JJ. Systematic review: Exposure to pets and risk of asthma and asthma-like symptoms. J Allergy Clin Immunol 2001; 107(3): 455-60.
    • 273. Mandhane PJ, Sears MR, Poulton R, et al. Cats and dogs and the risk of atopy in childhood and adulthood. J Allergy Clin Immunol 2009; 124(4): 745-50 e4.
    • 274. Carrer P, Maroni M, Alcini D, et al. Assessment through environmental and biological measurements of total daily exposure to volatile organic compounds of office workers in Milan, Italy. Indoor Air 2000; 10(4): 258-68.
    • 275. Hirsch T, Hering M, Burkner K, et al. House-dust-mite allergen concentrations (Der f 1) and mold spores in apartment bedrooms before and after installation of insulated windows and central heating systems. Allergy 2000; 55(1): 79-83.
    • 276. Blanc PD, Yen IH, Chen H, et al. Area-level socio-economic status and health status among adults with asthma and rhinitis. European Respiratory Journal 2006; 27(1): 85-94.
    • 277. Franchi M, Carrer P, Kotzias D, et al. Working towards healthy air in dwellings in Europe. Allergy 2006; 61(7): 864-8.
    • 278. Denning DW, O'Driscoll BR, Hogaboam CM, Bowyer P, Niven RM. The link between fungi and severe asthma: a summary of the evidence. Eur Respir J 2006; 27(3): 615-26.
    • 279. Nicolai T, Illi S, von Mutius E. Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence. Thorax 1998; 53(12): 1035-40.
    • 280. Williamson IJ, Martin CJ, McGill G, Monie RD, Fennerty AG. Damp housing and asthma: a case-control study. Thorax 1997; 52(3): 229-34.
    • 281. Burr ML, Matthews IP, Arthur RA, et al. Effects on patients with asthma of eradicating visible indoor mould: a randomised controlled trial. Thorax 2007; 62(9): 767-72.
    • 282. USA EpaE. An introduction to indoor air quality (IAQ). 2012. http://www.epa.gov/iaq/no2.html#Sources (accessed 4th January 2014.
    • 283. Lin W, Brunekreef B, Gehring U. Meta-analysis of the effects of indoor nitrogen dioxide and gas cooking on asthma and wheeze in children. Int J Epidemiol 2013.
    • 284. Withers NJ, Low L, Holgate ST, Clough JB. The natural history of respiratory symptoms in a cohort of adolescents. Am J Respir Crit Care Med 1998; 158(2): 352-7.
    • 285. Garrett MH, Hooper MA, Hooper BM, Abramson MJ. Respiratory symptoms in children and indoor exposure to nitrogen dioxide and gas stoves. Am J Respir Crit Care Med 1998; 158(3): 891-5.
    • 286. Ponsonby AL, Dwyer T, Kemp A, Couper D, Cochrane J, Carmichael A. A prospective study of the association between home gas appliance use during infancy and subsequent dust mite sensitization and lung function in childhood. Clin Exp Allergy 2001; 31(10): 1544-52.
    • 287. Phoa LL, Toelle BG, Ng K, Marks GB. Effects of gas and other fume emitting heaters on the development of asthma during childhood. Thorax 2004; 59(9): 741-5.
    • 288. Sherriff A, Golding J, Alspac Study T. Hygiene levels in a contemporary population cohort are associated with wheezing and atopic eczema in preschool infants. Arch Dis Child 2002; 87(1): 26-9.
    • 289. Korhonen L, Kondrashova A, Tauriainen S, et al. Enterovirus infections in early childhood and the risk of atopic disease--a nested case-control study. Clin Exp Allergy 2013; 43(6): 625-32.
    • 290. Burgess JA, Abramson MJ, Gurrin LC, et al. Childhood infections and the risk of asthma: a longitudinal study over 37 years. Chest 2012; 142(3): 647-54.
    • 291. von Mutius E, Illi S, Hirsch T, Leupold W, Keil U, Weiland SK. Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children. Eur Respir J 1999; 14(1): 4-11.
    • 292. Collier CH, Risnes K, Norwitz ER, Bracken MB, Illuzzi JL. Maternal Infection in Pregnancy and Risk of Asthma in Offspring. Maternal & Child Health Journal 2013; 17(10): 1940-50.
    • 293. Bodner C, Godden D, Seaton A. Family size, childhood infections and atopic diseases. The Aberdeen WHEASE Group. Thorax 1998; 53(1): 28-32.
    • 294. McKeever TM, Lewis SA, Smith C, et al. Siblings, multiple births, and the incidence of allergic disease: a birth cohort study using the West Midlands general practice research database. Thorax 2001; 56(10): 758-62.
    • 295. Braback L, Hedberg A. Perinatal risk factors for atopic disease in conscripts. Clin Exp Allergy 1998; 28(8): 936-42.
    • 296. Sunyer J, Anto JM, Kogevinas M, et al. Risk factors for asthma in young adults. Spanish Group of the European Community Respiratory Health Survey. Eur Respir J 1997; 10(11): 2490-4.
    • 297. Pekkanen J, Remes S, Kajosaari M, Husman T, Soininen L. Infections in early childhood and risk of atopic disease. Acta Paediatr 1999; 88(7): 710-4.
    • 298. Ponsonby AL, Couper D, Dwyer T, Carmichael A, Kemp A. Relationship between early life respiratory illness, family size over time, and the development of asthma and hay fever: a seven year follow up study. Thorax 1999; 54(8): 664-9.
    • 299. Adams M, Doull I. Birth by caesarean section and asthma. Clin Exp Allergy 2008; 38(4): 554-6.
    • 300. Martignon G, Oryszczyn MP, Annesi-Maesano I. Does childhood immunization against infectious diseases protect from the development of atopic disease? Pediatr Allergy Immunol 2005; 16(3): 193-200.
    • 301. Thomson JA, Widjaja C, Darmaputra AAP, et al. Early childhood infections and immunisation and the development of allergic disease in particular asthma in a high-risk cohort: A prospective study of allergy-prone children from birth to six years. Pediatric Allergy and Immunology 2010; 21(7): 1076-85.
    • 302. McDonald KL, Huq SI, Lix LM, Becker AB, Kozyrskyj AL. Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma. J Allergy Clin Immunol 2008; 121(3): 626-31.
    • 303. Nakajima K, Dharmage SC, Carlin JB, et al. Is childhood immunisation associated with atopic disease from age 7 to 32 years? Thorax 2007; 62(3): 270-5.
    • 304. Thomson JA, Widjaja C, Darmaputra AA, et al. Early childhood infections and immunisation and the development of allergic disease in particular asthma in a highrisk cohort: A prospective study of allergy-prone children from birth to six years. Pediatr Allergy Immunol 2010; 21(7): 1076-85.
    • 305. NICE. NICE guidance on Caesarean section. http://wwwniceorguk/nicemedia/live/13620/57162/57162pdf, 2011. (accessed 12th May 2013).
    • 306. Thavagnanam S, Fleming J, Bromley A, Shields MD, Cardwell CR. A metaanalysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy 2008; 38(4): 629-33.
    • 307. Bager P, Wohlfahrt J, Westergaard T. Caesarean delivery and risk of atopy and allergic disease: meta-analyses. Clin Exp Allergy 2008; 38(4): 634-42.
    • 308. Pistiner M, Gold DR, Abdulkerim H, Hoffman E, Celedon JC. Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy. J Allergy Clin Immunol 2008; 122(2): 274-9.
    • 309. Roduit C, Scholtens S, de Jongste JC, et al. Asthma at 8 years of age in children born by caesarean section. Thorax 2009; 64(2): 107-13.
    • 310. Breton MC, Beauchesne MF, Lemiere C, Rey E, Forget A, Blais L. Risk of perinatal mortality associated with asthma during pregnancy. Thorax 2009; 64(2): 101-6.
    • 311. Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 2001; 163(2): 429-36.
    • 312. Gilliland FD, Berhane K, McConnell R, et al. Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax 2000; 55(4): 271-6.
    • 313. Cook DG, Strachan DP. Health effects of passive smoking. 3. Parental smoking and prevalence of respiratory symptoms and asthma in school age children. Thorax 1997; 52(12): 1081-94.
    • 314. Tinuoye O, Pell JP, Mackay DF. Meta-analysis of the association between secondhand smoke exposure and physician-diagnosed childhood asthma. Nicotine Tob Res 2013; 15(9): 1475-83.
    • 315. Burke H, Leonardi-Bee J, Hashim A, et al. Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and metaanalysis. Pediatrics 2012; 129(4): 735-44.
    • 316. Agabiti N, Mallone S, Forastiere F, et al. The impact of parental smoking on asthma and wheezing. SIDRIA Collaborative Group. Studi Italiani sui Disturbi Respiratori nell'Infanzia e l'Ambiente. Epidemiology 1999; 10(6): 692-8.
    • 317. Al Mamun A, O'Callaghan FV, Alati R, et al. Does maternal smoking during pregnancy predict the smoking patterns of young adult offspring? A birth cohort study. Tob Control 2006; 15(6): 452-7.
    • 318. Jaakkola MS, Piipari R, Jaakkola N, Jaakkola JJ. Environmental tobacco smoke and adult-onset asthma: a population-based incident case-control study. Am J Public Health 2003; 93(12): 2055-60.
    • 319. (ASH) Aosah. Smoking statistics who smokes and how much. 2013. http://ash.org.uk/files/documents/ASH_106.pdf2014).
    • 320. Busse WW, Lemanske RF, Jr., Gern JE. Role of viral respiratory infections in asthma and asthma exacerbations. Lancet; 376(9743): 826-34.
    • 321. Renz H, Herz U. The bidirectional capacity of bacterial antigens to modulate allergy and asthma. Eur Respir J 2002; 19(1): 158-71.
    • 322. Lane J, Siebers R, Pene G, Howden-Chapman P, Crane J. Tokelau: a unique low allergen environment at sea level. Clin Exp Allergy 2005; 35(4): 479-82.
    • 323. Gereda JE, Leung DY, Thatayatikom A, et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000; 355(9216): 1680-3.
    • 324. Park JH, Gold DR, Spiegelman DL, Burge HA, Milton DK. House dust endotoxin and wheeze in the first year of life. Am J Respir Crit Care Med 2001; 163(2): 322-8.
    • 325. Braun-Fahrlander C, Riedler J, Herz U, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347(12): 869-77.
    • 326. Bernsen RM, van der Wouden JC, Nagelkerke NJ, de Jongste JC. Early life circumstances and atopic disorders in childhood. Clin Exp Allergy 2006; 36(7): 858- 65.
    • 327. Nymand G. Letter: Maternal smoking and immunity. Lancet 1974; 2(7893): 1379-80.
    • 328. Feleszko W, Ruszczynski M, Jaworska J, Strzelak A, Zalewski BM, Kulus M. Environmental tobacco smoke exposure and risk of allergic sensitisation in children: a systematic review and meta-analysis. Arch Dis Child 2014.
    • 329. Holt PG. Immune and inflammatory function in cigarette smokers. Thorax 1987; 42(4): 241-9.
    • 330. Reed CE. The natural history of asthma. J Allergy Clin Immunol 2006; 118(3): 543-8; quiz 9-50.
    • 331. Bai TR, Vonk JM, Postma DS, Boezen HM. Severe exacerbations predict excess lung function decline in asthma. Eur Respir J 2007; 30(3): 452-6.
    • 332. Guerra S, Wright AL, Morgan WJ, Sherrill DL, Holberg CJ, Martinez FD. Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty. Am J Respir Crit Care Med 2004; 170(1): 78-85.
    • 333. Vonk JM, Postma DS, Boezen HM, et al. Childhood factors associated with asthma remission after 30 year follow up. Thorax 2004; 59(11): 925-9.
    • 334. Panhuysen CI, Vonk JM, Koeter GH, et al. Adult patients may outgrow their asthma: a 25-year follow-up study. Am J Respir Crit Care Med 1997; 155(4): 1267-72.
    • 335. Dijkstra A, Vonk JM, Jongepier H, et al. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex. Thorax 2006; 61(2): 105- 10.
    • 336. Vonk JM, Jongepier H, Panhuysen CI, Schouten JP, Bleecker ER, Postma DS. Risk factors associated with the presence of irreversible airflow limitation and reduced transfer coefficient in patients with asthma after 26 years of follow up. Thorax 2003; 58(4): 322-7.
    • 337. Stern DA, Morgan WJ, Wright AL, Guerra S, Martinez FD. Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study. Lancet 2007; 370(9589): 758-64.
    • 338. Sporik R, Holgate ST, Cogswell JJ. Natural history of asthma in childhood--a birth cohort study. Arch Dis Child 1991; 66(9): 1050-3.
    • 339. Mochizuki H, Shigeta M, Arakawa H, Kato M, Tokuyama K, Morikawa A. Bronchial hyperresponsiveness before and after the diagnosis of bronchial asthma in children. Pediatrics 2000; 106(6): 1442-6.
    • 340. Porsbjerg C, von Linstow ML, Ulrik CS, Nepper-Christensen SC, Backer V. Outcome in adulthood of asymptomatic airway hyperresponsiveness to histamine and exercise-induced bronchospasm in childhood. Ann Allergy Asthma Immunol 2005; 95(2): 137-42.
    • 341. Jones A. Asymptomatic bronchial hyperreactivity and the development of asthma and other respiratory tract illnesses in children. Thorax 1994; 49(8): 757-61.
    • 342. Rasmussen F, Lambrechtsen J, Siersted HC, Hansen HS, Hansen NC. Asymptomatic bronchial hyperresponsiveness to exercise in childhood and the
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