LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Abdulkadir, Bashir; Nelson, Andrew; Skeath, Tom; Marrs, Emma; Perry, John; Cummings, Stephen; Embleton, Nicholas; Berrington, Janet; Stewart, Christopher (2016)
Publisher: Karger
Languages: English
Types: Article
Subjects: A100, C500

Classified by OpenAIRE into

mesheuropmc: digestive system, food and beverages
Identifiers:doi:10.1159/000442936
Objective - Probiotics are live microbial supplements that colonize the gut and potentially exert health benefit to the host. We aimed to determine the impact of probiotic (Infloran®: Lactobacillus acidophilus-NCIMB701748 and Bifidobacterium bifidum-ATCC15696) on the bacterial and metabolic function of the preterm gut while on the neonatal intensive care unit (NICU) and following discharge. \ud \ud Patients - Stool samples (n = 88) were collected before, during, and after probiotic intake from 7 patients, along with time-matched controls from 3 patients. Samples were also collected following discharge home from the NICU. \ud \ud Methods - Samples underwent bacterial profiling analysis by 16S rRNA gene sequencing and quantitative PCR (qPCR), as well as metabolomics profiling using liquid chromatography mass spectrometry (LCMS). \ud \ud Results - Bacterial profiling showed greater Bifidobacterium (15.1%) and Lactobacillus (4.2%) during supplementation compared to the control group (4.0% and 0%, respectively). While Lactobacillus reduced after probiotic was stopped, Bifidobacterium remained high following discharge, suggestive of successful colonisation. qPCR analysis showed a significant increase (P = <0.01) of B. bifidum in infants who received probiotic treatment compared to controls, but no significant increase was observed for L. acidophilus (P = 0.153). Metabolite profiling showed clustering based on receiving probiotic or matched controls, with distinct metabolites associated with probiotic administration.\ud \ud Conclusions - Probiotic species successfully colonise the preterm gut, reducing the relative abundance of potentially pathogenic bacteria, and affecting gut functioning. Bifidobacterium (but not Lactobacillus) colonized the gut long-term; suggesting the possibility that therapeutically administered probiotics may continue to exert important functional effects on gut microbial communities in early infancy.
  • No references.
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article