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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Zhang, Ran; Naughton, Declan P (2010)
Publisher: BioMed Central
Journal: Nutrition Journal
Languages: English
Types: Article
Subjects: Nutrition. Foods and food supply, Nutritional diseases. Deficiency diseases, alliedhealth, TX341-641, Review, RC620-627


Despite the numerous reports of the association of vitamin D with a spectrum of development, disease treatment and health maintenance, vitamin D deficiency is common. Originating in part from the diet but with a key source resulting from transformation by exposure to sunshine, a great deal of the population suffers from vitamin D deficiency especially during winter months. It is linked to the treatment and pathogenesis and/or progression of several disorders including cancer, hypertension, multiple sclerosis, rheumatoid arthritis, osteoporosis, muscle weakness and diabetes. This widespread deficiency of Vitamin D merits consideration of widespread policies including increasing awareness among the public and healthcare professionals.

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    • 1. Wolpowitz D, Gilchrest BA: The vitamin D questions: how much do you need and how should you get it? J Am Acad Dermatol 2006, 54:301-317.
    • 2. Holick MF: The use and interpretation of assays for vitamin D and its metabolites. J Nutr 1990, 120(Suppl):1464-1469.
    • 3. Vieth R: Why ''vitamin D'' is not a hormone, and not a synonym for 1,25 dihydroxy-vitamin D, its analogs or deltanoids. J Steroid Biochem Mol Biol 2004, 89-90:571-573.
    • 4. Holick MF: The role of vitamin D for bone health and fracture prevention. Curr Osteoporos Rep 2006, 4:96-102.
    • 5. Malone RW, Kessenich C: Vitamin D deficiency: implications across the lifespan, the journal for nurse practitioners. J Nurse Practitioners 2008, 6:448-454.
    • 6. Holick MF: Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 2004, 79:362-371.
    • 7. Tangpricha V, Koutkia P, Rieke SM, Chen TC, Perez AA, Holick MF: Fortification of orange juice with vitamin D: a novel approach to enhance vitamin D nutritional health. Am J Clin Nutr 2003, 77:1478-1483.
    • 8. Holick MF, Garabedian M: Vitamin D: photobiology, metabolism, mechanism of action, and clinical applications. In Primer on the metabolic bone diseases and disorders of mineral metabolism. 6 edition. Edited by: Favus MJ. Washington, DC: American Society for Bone and Mineral Research; 2006:129-137.
    • 9. Bouillon R: Vitamin D: from photosynthesis, metabolism, and action to clinical applications. In Endocrinology. Edited by: DeGroot LJ, Jameson JL. Philadelphia: W.B. Saunders; 2001:1009-1028.
    • 10. DeLuca HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004, 80:1689S-1696S.
    • 11. Adams JS, Clemens TL, Parrish JA, Holick MF: Vitamin-D synthesis and metabolism after ultraviolet irradiation of normal and vitamin-Ddeficient subjects. N Engl J Med 1982, 306:722-725.
    • 12. Reichel H, Koeffler HP, Norman AW: The role of the vitamin D endocrine system in health and disease. N Engl J Med 1989, 320:980-991.
    • 13. Michael F: Vitamin D Deficiency. N Engl J Med 2007, 357:266-281.
    • 14. Holick MF, Siris ES, Binkley N, Beard MK, Khan A, Katzer JT, Petruschke RA, Chen E, de Papp AE: Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab 2005, 90:3215-3224.
    • 15. Lips P, Hosking D, Lippuner K, Norquist JM, Wehren L, Maalouf G, Ragi-Eis S, Chandler J: The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Intern Med 2006, 260:245-254.
    • 16. Thomas KK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS: Hypovitaminosis D in medical inpatients. N Engl J Med 1998, 338:777-783.
    • 17. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R: Estimates of optimal vitamin D status. Osteoporos Int 2005, 16:713-716.
    • 18. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Food and Nutrition Board, Institute of Medicine. Vitamin D. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride Washington, DC: National Academy Press; 1999, 250-287.
    • 19. Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Thomsen J, Charles P, Eriksen EF: Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med 2000, 247:260-268.
    • 20. Boonen S, Bischoff-Ferrari HA, Cooper C, Lips P, Ljunggren O, Meunier PJ, Reginster JY: Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence. Calcif Tissue Int 2006, 78:257-270.
    • 21. Larsen ER, Mosekilde L, Foldspang A: Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study. J Bone Miner Res 2004, 19:370-378.
    • 22. Staud R: Vitamin D: more than just affecting calcium and bone. Curr Rheumatol Rep 2005, 7:356-364.
    • 23. Holick MF: Resurrection of vitamin D deficiency and rickets. J Clin Invest 2006, 116:2062-2072.
    • 24. Vieth R: Why the optimal requirement for vitamin D3 is probably much higher than what is officially recommended for adults. J Steroid Biochem Mol Biol 2004, 89-90:575-579.
    • 25. Bell NH: Vitamin D metabolism, aging, and bone loss. J Clin Endocrinol Metab 1995, 80:1051.
    • 26. Need AG, Morris HA, Horowitz M, Nordin C: Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D. Am J Clin Nutr 1993, 58:882-885.
    • 27. Clemens TL, Henderson SL, Adams JS, Holick MF: Increased skin pigment reduces the capacity of skin to synthesis vitamin D3. Lancet 1982, 1:74-76.
    • 28. Webb AR, Kline L, Holick MF: Influence of season and latitude on the cutaneous synthesis of vitaminD3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 1988, 67:373-378.
    • 29. Lu Z, Chen TC, Kline L, Markestad T, Pettifor J, Ladizesky M, Mautalen C, Holick MF: Photosynthesis of previtamin D3 in cities around the world. In Biologic effects of light. Edited by: Holick MF, Kligman A. Symposium proceedings, October 13-15:1991. Berlin: Walter De Gruyter 1992:48-51.
    • 30. Matsuoka LY, Ide L, Wortsman J, MacLaughlin J, Holick MF: Sunscreens suppress cutaneous vitamin D3 synthesis. J Clin Endocrinol Metab 1987, 64:1165-1168.
    • 31. Holick MF: McCollum Award Lecture, 1994: Vitamin D-new horizons for the 21st century. Am J Clin Nutr 1994, 60:619-630.
    • 32. Lo CW, Paris PW, Clemens TL, Nolan J, Holick MF: Vitamin D absorption in healthy subjects and in patients with intestinal malabsorption syndromes. Am J Clin Nutr 1985, 42:644-649.
    • 33. Pack AM, Morrell MJ: Epilepsy and bone health in adults. Epilepsy Behav 2004, 5(Suppl. 2):S24-S29.
    • 34. Andress DL, Ozuna J, Tirschwell D, Grande L, Johnson M, Jacobson AF, Spain W: Antiepileptic drug induced bone loss in young male patients who have seizures. Arch Neurol 2002, 59:781-786.
    • 35. Burt R, Freston JW, Tolman KG: The influence of phenobarbital on biotransformation of 25-hydroxycholecalciferol. J Clin Pharmacol 1976, 16:393-398.
    • 36. Shah SC, Sharma RK, Chitle AR: Rifampicin induced osteomalacia. Tubercle 1981, 62:207-209.
    • 37. Karaaslan Y, Haznedaroglu S, Ozturk M: Osteomalacia associated with carbamazepine/valproate. Ann Pharmacother 2000, 34:264-265.
    • 38. Dusso AS, Sato T, Arcidiacono MV, Alvarez-Hernandez D, Yang J, GonzalezSuarez I, Tominaga Y, Slatopolsky E: Pathogenic mechanisms for parathyroid hyperplasia. Kidney Int Suppl 2006, 102:S8-S11.
    • 39. Correa P, Segersten U, Hellman P, Akerstrom G, Westin G: Increased 25- hydroxyvitamin D3 1α-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors - new prospects for treatment of hyperparathyroidism with vitamin D. J Clin Endocrinol Metab 2002, 87:5826-5829.
    • 40. Liel Y, Ulmer E, Shary J, Hollis BW, Bell NH: Low circulating vitamin D in obesity. Calcif Tissue Int 1988, 43:199-201.
    • 41. Compston JE, Vedi S, Ledger JE, Webb A, Gazet JC, Pilkington TRE: Vitamin D status and bone histomorphometry in gross obesity. Am J Clin Nutr 1981, 34:2359-2363.
    • 42. Hey H, Stockholm KH, Lund BJ, Sorensen OH: Vitamin D deficiency in obese patients and changes in circulating vitamin D metabolites following jejunoileal bypass. Int J Obes 1982, 6:473-479.
    • 43. Hyldstrup L, Andersen T, McNair P, Breum L, Transbol I: Bone metabolism in obesity: changes related to severe overweight and dietary weight reduction. Acta Endocrinol 1993, 129:393-398.
    • 44. MacLaughlin J, Holick MF: Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 1985, 76:1536-1538.
    • 45. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF: Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000, 72:690-693.
    • 46. Sullivan SS, Rosen CJ, Halteman WA, Chen TC, Holick MF: Adolescent girls in Maine at risk for vitamin D insufficiency. J Am Diet Assoc 2005, 105:971-974.
    • 47. Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ: Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med 2004, 158:531-537.
    • 48. Lips P: Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001, 22:477-501.
    • 49. Bakhtiyarova S, Lesnyak O, Kyznesova N, Blankenstein MA, Lips P: Vitamin D status among patients with hip fracture and elderly control subjects in Yekaterinburg, Russia. Osteoporos Int 2006, 17:441-446.
    • 50. McKenna MJ: Differences in vitamin D status between countries in young adults and the elderly. Am J Med 1992, 93:69-77.
    • 51. Hypponen and Power: Hypovitaminosis D in British adults at age 45y: nationwide cohort study on dietary and lifestyle predictors. Am J Clin Nutr 2007, 85:860-868.
    • 52. MacLaughlin JA, Anderson RR, Holick MF: Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. Science 1982, 216:1001-1003.
    • 53. Hess AF: In Collected writings. Volume I. Springfield, IL: Charles C Thomas; 1936:669-719.
    • 54. Hess AF, Unger LJ: The cure of infantile rickets by sunlight. JAMA 1921, 77:39.
    • 55. Holick MF: Sunlight and vitamin D for bone health and prevention of autoimmune disease, cancers, and cardiovascular disease. Am J Clin Nutr 2004, 80(suppl):1678S-1688S.
    • 56. Tejasvi T, Sharma VK, Kaur J: Determination of minimal erythemal dose for narrow band-ultraviolet B radiation in north Indian patients: comparison of visual and Dermaspectrometer® readings. Indian J Dermatol Venereol Leprol 2007, 73:97-99.
    • 57. Holick MF: Sunlight “D"ilemma: risk of skin cancer or bone disease and muscle weakness. Lancet 2001, 357:4-6.
    • 58. Corless D, Gupta SP, Switala S, Barragry JM, Boucher BJ, Cohen RD, Diffey BL: Response of plasma-25-hydroxyvitamin D to ultraviolet irradiation in long-stay geriatric patients. Lancet 1978, 649-651.
    • 59. Toss G, Andersson R, Diffey BL, Fall PA, Larkö O, Larsson L: Oral vitamin D and ultraviolet radiation for the prevention of vitamin D deficiency in the elderly. Acta Med Scand 1982, 212:157-161.
    • 60. Chel VGM, Ooms ME, Popp-Snijders C, Pavel S, Schothorst AA, Meulemans CC, Lips P: Ultraviolet irradiation corrects vitamin D deficiency and suppresses secondary hyperparathyroidism in the elderly. J Bone Min Res 1998, 13:1238-1242.
    • 61. Snell AP, MacLennan WJ, Hamilton JC: Ultra-violet irradiation and 25 hydroxyvitamin D levels in sick old people. Age Ageing 1978, 7:225-228.
    • 62. Chel VGM., Ooms ME, Popp-snijders C, Pavel S, Schothorst AA, Meulemans CCE, Lips P: Ultraiovlet irradiation corrects vitamin D deficiency and suppresses secondary hyperparathyroidism in the elderly. J Bone Mineral Res 1998, 13:1238-1242.
    • 63. Chandra P, Wolfenden LL, Ziegler TR, Tian J, Luo M, Stecenko AA, Chen TC, Holick MF, Tangpricha V: Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: a case series. Photodermatol Photoimmunol Photomed 2007, 23:179-185.
    • 64. Scott PM: CLAYTON'S electrotherapy and actinotherapy. 6 edition. London: Bailliere Tindall & Cassell; 1969.
    • 65. Mussolino ME, Gillum RF: Low bone mineral density and mortality in men and women: The Third National Health and Nutrition Examination Survey Linked Mortality File. Ann Epidemiol 2008, 18:847-850.
    • 66. Suzuki T, Yoshida H: Low bone mineral density at femoral neck is a predictor of increased mortality in elderly Japanese women. Osteoporosis Int 2010, 21:71-79.
    • 67. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, DawsonHughes B: Fracture prevention with vitamin D supplementation: a metaanalysis of randomized controlled trials. JAMA 2005, 293:2257-2264.
    • 68. Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ: Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992, 327:1637-1642.
    • 69. Chapuy MC, Arlot ME, Delmas PD, Meunier PJ: Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ 1994, 308:1081-1082.
    • 70. Lips P, Graafmans WC, Ooms ME, Bezemer PD, Bouter LM: Vitamin D supplementation and fracture incidence in elderly persons: a randomized, placebo-controlled clinical trial. Ann Intern Med 1996, 124:400-406.
    • 71. Nieves J, Cosman F, Herbert J, Shen V, Lindsay R: High prevalence of vitamin D deficiency and reduced bone mass in multiple sclerosis. Neurology 1994, 44:1687-1692.
    • 72. Plotnikoff GA, Quigley JM: Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 2003, 78:1463-1470.
    • 73. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B: Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006, 84:18-28.
    • 74. Broe KE, Chen TC, Weinberg J, Bischoff-Ferrari HA, Holick MF, Kiel DP: A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study. J Am Geriatr Soc 2007, 55:234-239.
    • 75. Graafmans WC, Ooms ME, Hofstee HM, Bezemer PD, Bouter LM, Lips P: Falls in the elderly: a prospective study of risk factors and risk profiles. Am J Epidemiol 1996, 143:1129-1136.
    • 76. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP: 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002, 110:229-238.
    • 77. Carthy EP, Yamashita W, Hsu A, Ooi BS: 1,25-Dihydroxyvitamin D3 and rat vascular smooth muscle cell growth. Hypertension 1989, 13:954-959.
    • 78. Lee JH, O'Keefe JH, Bell D, Hensrud DD, Holick MF: Vitamin D deficiency an important, common, and easily treable cardiovascular risk factor? J Am Coll Cardio 2008, 52:1949-1956.
    • 79. Michos ED, Melamed ML: Vitamin D and cardiovascular disease risk. Curr Opin Clin Nutr Metab Care 2008, 11:7-12.
    • 80. Dustan HP: Obesity and hypertension in blacks. Cardiovasc Drugs Ther 1990, 4(Suppl. 2):395-402.
    • 81. Harris SS, Dawson-Hughes B: Seasonal changes in plasma 25 hydroxyvitamin D concentrations of young American black and white women. Am J Clin Nutr 1998, 67:1232-1236.
    • 82. Kunes J, Tremblay J, Bellavance F, Hamet P: Influence of environmental temperature on the blood pressure of hypertensive patients in Montreal. Am J Hypertens 1991, 4:422-426.
    • 83. Woodhouse PR, Khaw KT, Plummer M: Seasonal variation of blood pressure and its relationship to ambient temperature in an elderly population. J Hypertens 1993, 11:1267-1274.
    • 84. Krause R, Buhring M, Hopfenmuller W, Holick MF, Sharma AM: Ultraviolet B and blood pressure. Lancet 1998, 352:709-710.
    • 85. Pfeifer M, Begerow B, Minne HW, Nachtigall D, Hansen C: Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab 2001, 86:1633-1637.
    • 86. Forman JP, Bischoff-Ferrari HA, Willett WC, Stampfer MJ, Curhan GC: Vitamin D intake and risk of incident hypertension results from three large prospective cohort studies. Hypertension 2005, 46:676-682.
    • 87. Martyn CN: The epidemiology of multiple sclerosis. McAlpine's Multiple Sclerosis. 2 edition. WB Matthews ed. Edinburgh London Melbourne and New York: Churchill Livingstone; 1991.
    • 88. Gale CR, Martyn CN: Migrant studies in multiple sclerosis. Prog Neurobiol 1995, 47:425-448.
    • 89. Acheson ED, Bachrach CD, Wright FM: Some comments on the relationship of the distribution of multiple sclerosis to latitude, solar radiation and other variables. Acta Psychiatr Scand 1960, 35:132-147.
    • 90. Norman JE, Kurtzke JF, Beebe GW: Epidemiology of multiple sclerosis in US veterans: 2. Latitude, climate and the risk of multiple sclerosis. J Chronic Dis 1983, 36:551-559.
    • 91. Goldberg P: Multiple sclerosis: vitamin D and calcium as environmental determinants of prevalence (a viewpoint). Part 1: sunlight, dietary factors and epidemiology. Int J Environ Studies 1974, 6:19-27.
    • 92. Acheson ED, Bachrach CA, Wright FM: Some comments on the relationship of the distribution of multiple sclerosis to latitude, solar radiation, and other variables. Acta Psychiatry Scand 1960, 147(suppl):132-147.
    • 93. Sutherland JM, Tyrer JH, Eadie MJ: The prevalence of multiple sclerosis in Australia. Brain 1962, 85:146-164.
    • 94. Cosman F, Nieves J, Herbert J, Shen V, Lindsay R: High-dose glucocorticoids in multiple sclerosis patients exert direct effects on the kidney and skeleton. J Bone Miner Res 1994, 9:1097-1105.
    • 95. VanAmerongen BM, Dijkstra CD, Lips P, Polman CH: Multiple sclerosis and vitamin D: an update. Eur J Clin Nutr 2004, 58:1095-1109.
    • 96. Cantorna MT: Vitamin D and multiple sclerosis: an update. Nutr Rev 2008, 66(10 Suppl 2):S135-138.
    • 97. Raghuwanshi A, Joshi SS, Christakos S: Vitamin D and multiple sclerosis. J Cell Biochem 2008, 105:338-343.
    • 98. Mahon BD, Gordon SA, Cruz J, Cosman F, Cantorna MT: Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. J Neuroimmunol 2003, 134:128-132.
    • 99. Munger KL, Zhang SM, O'Reilly E, Hernan MA, Olek MJ, Willett WC, Ascherio A: Vitamin D intake and incidence of multiple sclerosis. Neurology 2004, 62:60-65.
    • 100. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A: Serum 25- hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006, 296:2832-2838.
    • 101. Aris RM, Merkel PA, Bachrach LK, Borowitz DS, Boyle MP, Elkin SL, Guise TA, Hardin DS, Haworth CS, Holick MF, Joseph PM, O'Brien K, Tullis E, Watts NB, White TB: Consensus statement: guide to bone health and disease in cystic fibrosis. J Clin Endocrinol Metab 2005, 90:1888-1896.
    • 102. Siffledeen J, Fedorak R, Siminoski K, Jen H, Vaudan E, Abraham N, Steinhart H, Greenberg G: Randomized trial of etidronate plus calcium and vitamin D for treatment of low bone mineral density in Crohn's disease. Clin Gastroenterol Hepatol 2005, 3:122-132.
    • 103. Peller S, Stephenson CS: Skin irritation and cancer in the United States Navy. Am J Med Sci 1937, 194:326-333.
    • 104. Garland C, Garland F: Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 1980, 9:227-231.
    • 105. Gorham E, Garland C, Garland F: Acid haze air pollution and breast and colon cancer in 20 Canadian cities. Can J Public Health 1989, 80:96-100.
    • 106. Garland F, Garland C, Gorham E, Young J Jr: Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med 1990, 19:614-622.
    • 107. Lefkowitz ES, Garland CF: Sunlight, vitamin D, and ovarian cancer mortality rates in US women. Int J Epidemiol 1994, 23:1133-1136.
    • 108. Schwartz GG, Hulka BS: Is vitamin D deficiency a risk factor for prostate cancer? Anticancer Res 1990, 10:1307-1311.
    • 109. Young MR, Ihm J, Lozano Y, Wright MA, Prechel MM: Treating tumorbearing mice with vitamin D3 diminishes tumor-induced myelopoiesis and associated immunosuppression, and reduces tumor metastasis and recurrence. Cancer Immunol Immunother 1995, 41:37-45.
    • 110. Metz RJ, Vellody K, Patel S, Bergstrom R, Meisinger J, Jackson J, Wright MA, Young MR: Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A. Invasion Metastasis 1996, 16:280-290.
    • 111. Young MR, Halpin J, Hussain R, Lozano Y, Djordjevic A, Devata S, Matthews JP, Wright MA: Inhibition of tumor production of granulocyte-macrophage colony-stimulating factor by 1 alpha, 25-dihydroxyvitamin D3 reduces tumor motility and metastasis. Invasion Metastasis 1993, 13:169-177.
    • 112. Evans SR, Shchepotin EI, Young H, Rochon J, Uskokovic M, Shchepotin IB: 1,25-dihydroxyvitamin D3 synthetic analogs inhibit spontaneous metastases in a 1,2-dimethylhydrazine-induced colon carcinogenesis model. Int J Oncol 2000, 16:1249-1254.
    • 113. Fujioka T, Hasegawa M, Ishikura K, Matsushita Y, Sato M, Tanji S: Inhibition of tumor growth and angiogenesis by vitamin D3 agents in murine renal cell carcinoma. J Urol 1998, 160:247-251.
    • 114. Sundaram S, Sea A, Feldman S, Strawbridge R, Hoopes PJ, Demidenko E, Binderup L, Gewirtz DA: The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice. Clin Cancer Res 2003, 9:2350-2356.
    • 115. Lokeshwar BL, Schwartz GG, Selzer MG, Burnstein KL, Zhuang SH, Block NL, Binderup L: Inhibition of prostate cancer metastasis in vivo: a comparison of 1,23-dihydroxyvitamin D (calcitriol) and EB1089. Cancer Epidemiol Biomarkers Prev 1999, 8:241-248.
    • 116. Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF: The role of vitamin D in cancer prevention. Am J Public Health 2006, 96:252-261.
    • 117. Bouillon R, Eelen G, Verlinden L, Mathieu C, Carmeliet G, Verstuyf A: Vitamin D and cancer. J Steroid Biochem Mol Biol 2006, 102:156-162.
    • 118. Tuohimaa P: Vitamin D, aging, and cancer. Nutr Rev 2008, 66:S147-152.
    • 119. Ishihara J, Inoue M, Iwasaki M, Sasazuki S, Tsugane S: Dietary calcium, vitamin D, and the risk of colorectal cancer. Am J Clin Nutr 2008, 88:1576-1583.
    • 120. Colston KW: Vitamin D and breast cancer risk. Best Pract Res Clin Endocrinol Metab 2008, 22:587-599.
    • 121. Lappe JM, Travers-Gustafason D, Davies KM, Recker RR, Heaney RP: Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007, 85:1586-1591.
    • 122. Dembrow M: High vitamin D: Rx for cancer prevention? Clin Advisor 2007, 10:54-57.
    • 123. Khosla S, Melton LJ III: Osteopenia. New Engl J Med 2007, 356:2293-2300.
    • 124. Symmons DP: Epidemiology of rheumatoid arthritis: determinants of onset, persistence and outcome. Best Pract Res Clin Rheumatol 2002, 16:707-722.
    • 125. Adams JS: Extrarenal production and action of active vitamin D metabolites in human lymphoproliferative diseases. In Vitamin D. Edited by: Feldman D. San Diego: Academic Press; 1997:903-921.
    • 126. Merlino L, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, Saag KG: Vitamin D intake is inversely associated with rheumatoid arthritis. Results from the Iowa Women's Health Study. Arthr Rheumat 2004, 50:72-77.
    • 127. Leventis P, Patel S: Clinical aspects of vitamin D in the management of rheumatoid arthritis. Rheumatology 2008, 47:1617-1621.
    • 128. Cutolo M, Otsa K, Uprus M, Paolino S, Seriolo B: Vitamin D in rheumatoid arthritis. Autoimmn Rev 2007, 7:59-64.
    • 129. Cantorna MT, Hayes CE, DeLuca HF: 1,25-dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis. J Nutr 1998, 128:68-72.
    • 130. Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, Saag KG: Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum 2004, 50:72-77.
    • 131. Wild S, Roglic G, Green A, Sicree R, King H: Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27:1047-1053.
    • 132. Norman AW, Frankel JB, Heldt AM, Grodsky GM: Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 1980, 209:823-825.
    • 133. Bourlon PM, Billaudel B, Faure-Dussert A: Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. J Endocrinol 1999, 160:87-95.
    • 134. Mohr SB, Garland CF, Gorham ED, Garland FC: The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia 2008, 51:1391-1398.
    • 135. Mathieu C, Badenhoop K: Vitamin D and type 1 diabetes mellitus: state of the art. Trends Endocrinol Metab 2005, 16:261-266.
    • 136. Zippitis CS, Akobeng AK: Vitamin D suuplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child 2008, 93:512-517.
    • 137. Peechakara SV, Pittas AG: Vitamin D as a potential modifier of diabetes risk. Nat Clin Pract Engocrinol Metab 2008, 4:182-183.
    • 138. Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE, Hu FB: Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006, 29:650-656.
    • 139. Hypponen E, Laara E, Reunanen A, Jarvelin M-R, Virtanen SM: Intake of vitamin D and risk of type 1 diabetes: a birthcohort study. Lancet 2001, 358:1500-1503.
    • 140. Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC: Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country consensus statement. WHO Global Surveillance and Monitoring Project. JAMA 1999, 282:677-686.
    • 141. Martineau AR, Honecker F, Wilkinson RJ, Griffiths CJ: Vitamin D in the treatment of pulmonary tuberculosis. J Steroid Biochem Mol Biol 2007, 103:793-798.
    • 142. Chan TY, Poon P, Pang J, Swaminathan R, Chan CH, Nisar M, Williams CS, Davies PD: A study of calcium and vitamin D metabolism in Chinese patients with pulmonary tuberculosis. J Trop Med Hyg 1994, 97:26-30.
    • 143. Davies PDO, Church HA, Bovornkitti S, Chatumilind A, Byrachandra S: Altered vitamin D homeostasis in tuberculosis. Intern Med (Thailand) 1988, 4:45-47.
    • 144. Strachan DP, Powell KJ, Thaker A, Millard FJ, Maxwell JD: Vegetarian diet as a risk factor for tuberculosis in immigrant south London Asians. Thorax 1995, 50:175-180.
    • 145. Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Berry JL, Griffiths CJ: A single dose of vitamin D enhances immunity to Mycobacteria. Am J Respir Crit Care Med 2007, 176:208-213.
    • 146. Ong G: Periodontal reasons for tooth loss in an Asian population. J Clin Periodontol 1996, 23:307-309.
    • 147. Phipps KR, Stevens VJ: Relative contribution of caries and periodontal disease in adult tooth loss for an HMO dental population. J Pub Health Dent 1995, 55:250-252.
    • 148. Stabholz A, Babayof I, Mersel A, Mann J: The reasons for tooth loss in geriatric patients attending two surgical clinics in Jerusalem, Israel. Gerodontology 1997, 14:83-88.
    • 149. Park KS, Nam JH, Choi J: The short vitamin D receptor is associated with increased risk for generalized aggressive periodontitis. J Clin Periodontol 2006, 33:524-528.
    • 150. Krall EA: Osteoporosis and the risk of tooth loss. Clin Calcium 2006, 16:287-290.
    • 151. Ritchie CS, Joshipura K, Hung HC, Douglass CW: Nutrition as a mediator in the relation between oral and systemic disease: associations between specific measures of adult oral health and nutrition outcomes. Crit Rev Oral Biol Med 2002, 13:291-300.
    • 152. Marshall TA, Warren JJ, Hand JS, Xie XJ, Stumbo PJ: Oral health, nutrient intake and dietary quality in the very old. J Am Dent Assoc 2002, 133:1369-1379.
    • 153. Norlen P, Steen B, Birkhed D, Bjorn AL: On the relations between dietary habits, nutrients, and oral health in women at the age of retirement. Acta Odontol Scand 1993, 51:277-284.
    • 154. Krall EA, Wehler C, Garcia RI, Harris SS, Dawson-Hughes B: Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med 2001, 111:452-456.
    • 155. Lansowne AT, Provost SC: Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl) 1998, 135:319-323.
    • 156. Brown J, Bianco JI, McGrath JJ, Eyles DW: 1,25-Dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neurosci Lett 2003, 343:139-143.
    • 157. Burkert R, McGrath J, Eyles D: Vitamin D receptor expression in the embryonic rat brain. Neurosci Res Commun 2003, 33:63-71.
    • 158. Eyles D, Brown J, Mackay-Sim A, McGrath J, Feron F: Vitamin D3 and brain development. Neuroscience 2003, 118:641-653.
    • 159. McGrath JJ, Feron FP, Burne TH, Mackay-Sim A, Eyles DW: The neurodevelopmental hypothesis of schizophrenia: a review of recent developments. Ann Med 2003, 35:86-93.
    • 160. McCann JC, Ames BN: Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction. FASEB J 2008, 22:982-1001.
    • 161. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ: Distribution of the vitamin D receptor and 1α-hydroxylase in human brain. J Chem Neuroanat 2005, 29:21-30.
    • 162. Wang L, Manson JE, Song Y, Sesso HD: Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med 2010, 152:315-323.
    • 163. Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, Lichtenstein AH, Lau J, Balk EM: Systematic review: Vitamin D and cardiometabolic outcomes. Ann Intern Med 2010, 152:307-314.
    • 164. DIPART (Vitamin D Individual Patient Analysis of Randomized Trials) Group: Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 2010, 340:b5463.
    • 165. Annweiler C, Schott AM, Berrut G, Fantino B, Beauchet O: Vitamin D-related changes in physical performance: a systematic review. J Nutr Health Aging 2009, 13:893-898.
    • 166. Palmer SC, McGregor DO, Craig JC, Elder G, Macaskill P, Strippoli GF: Vitamin D compounds for people with chronic kidney disease not requiring dialysis. Cochrane Database Syst Rev 2009, 4:CD008175.
    • 167. Palmer SC, McGregor DO, Craig JC, Elder G, Macaskill P, Strippoli GF: Vitamin D compounds for people with chronic kidney disease requiring dialysis. Cochrane Database Syst Rev 2009, 4:CD005633.
    • 168. Ferguson JH, Chang AB: Vitamin D supplementation for cystic fibrosis. Cochrane Database Syst Rev 2009, 4:CD007298.
    • 169. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J: Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 2009, 339:b3692.
    • 170. Witham MD, Nadir MA, Struthers AD: Effect of vitamin D on blood pressure: a systematic review and meta-analysis. J Hypertens 2009, 10:1948-1954.
    • 171. Gillespie LD, Robertson MC, Gillespie WJ, Lamb SE, Gates S, Cumming RG, Rowe BH: Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev 2009, 2:CD007146.
    • 172. Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J: Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 2009, 169:551-561.
    • 173. Björkman M, Sorva A, Tilvis R: Responses of parathyroid hormone to vitamin D supplementation: a systematic review of clinical trials. Arch Gerontol Geriatr 2009, 48:160-166.
    • 174. Autier P, Gandini S: Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 2007, 167:1730-1737.
    • 175. Jackson C, Gaugris S, Sen SS, Hosking D: The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis. QJM 2007, 100:185-192.
    • 176. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B: Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005, 293:2257-2264.
    • 177. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, Staehelin HB, Bazemore MG, Zee RY, Wong JB: Effect of Vitamin D on falls: a metaanalysis. JAMA 2004, 291:1999-2006.
    • 178. Cranney A, Tugwell P, Zytaruk N, Robinson V, Weaver B, Adachi J, Wells G, Shea B, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group: Meta-analyses of therapies for postmenopausal osteoporosis. IV. Meta-analysis of raloxifene for the prevention and treatment of postmenopausal osteoporosis. Endocr Rev 2002, 23:524-528.
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