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Paul Walters; Elizabeth A Barley; Anthony Mann; Rachel Phillips; André Tylee
Publisher: Public Library of Science (PLoS)
Journal: PLoS ONE
Languages: English
Types: Article
Subjects: Coronary Artery Disease, Vascular Medicine, Research Article, Research Design, Behavioral and Social Aspects of Health, Angina, RANDOMIZED CONTROLLED-TRIAL, Mental Health and Psychiatry, PREVALENCE, RISK-FACTOR, Morphogenesis, Public and Occupational Health, Socioeconomic Aspects of Health, Health Care, Neuroses, MAJOR DEPRESSION, Biology and Life Sciences, Developmental Biology, Mood Disorders, Research and Analysis Methods, Clinical Research Design, MANAGING DEPRESSION, Medicine, Birth Defects, Cardiology, ANXIETY, Q, R, Mentalhealth, Science, MORTALITY, Primary Care, Medicine and Health Sciences, GENERAL-PRACTITIONERS, Congenital Heart Defects

Background: An association between depression and coronary heart disease is now accepted but there has been little primary care research on this topic. The UPBEAT-UK studies are centred on a cohort of primary patients with coronary heart disease assessed every six months for up to four years. The aim of this research was to determine the prevalence and associations of depression in this cohort at baseline.

Method: Participants with coronary heart disease were recruited from general practice registers and assessed for cardiac symptoms, depression, quality of life and social problems.

Results: 803 people participated. 42% had a documented history of myocardial infarction, 54% a diagnosis of ischaemic heart disease or angina. 44% still experienced chest pain. 7% had an ICD-10 defined depressive disorder. Factors independently associated with this diagnosis were problems living alone (OR 5.49, 95% CI 2.11-13.30), problems carrying out usual activities (OR 3.71, 95% CI 1.93-7.14), experiencing chest pain (OR 3.27, 95% CI 1.58-6.76), other pains or discomfort (OR 3.39, 95% CI 1.42-8.10), younger age (OR 0.95 per year 95% CI 0.92-0.98).

Conclusion: Problems living alone, chest pain and disability are important predictors of depression in this population.

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