Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Cardoso, Andre Zamith; Mears, Laura L. E.; Cattoz, Beatrice N.; Griffiths, Peter C.; Schweins, Ralf; Adams, Dave J. (2016)
Publisher: Royal Society of Chemistry
Journal: Soft Matter
Languages: English
Types: Article
Subjects: QD
Some functionalised dipeptides can form hydrogels when salts are added to solutions at high pH. We have used surface tension, conductivity, rheology, optical, confocal and scanning electron microscopy, 1H NMR and UV-Vis spectroscopy measurements to characterise fully the phase behaviour of solutions of one specific gelator, 2NapFF, at 25 °C at pH 10.5. We show that this specific naphthalene–dipeptide undergoes structural transformations as the concentration is increased, initially forming spherical micelles, then worm-like micelles, followed by association of these worm-like micelles. On addition of a calcium salt, gels are generally formed as long as worm-like micelles are initially present in solution, although there are structural re-organisations that occur at lower concentrations, allowing gelation at lower than expected concentration. Using IR and SANS, we show the differences between the structures present in the solution and hydrogel phases.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1 R. V. Ulijn and A. M. Smith, Chem. Soc. Rev., 2008, 37, 664-675.
    • 2 C.-Y. Yu, W. Huang, Z.-P. Li, X.-Y. Lei, D.-X. He and L. Sun, Curr. Top. Med. Chem., 2016, 16, 281-290.
    • 3 D. M. Leite, E. Barbu, G. J. Pilkington and A. Lalatsa, Curr. Top. Med. Chem., 2015, 15, 2277-2289.
    • 4 X. Du, J. Zhou, J. Shi and B. Xu, Chem. Rev., 2015, 115, 13165-13307.
    • 5 V. Jayawarna, M. Ali, T. A. Jowitt, A. F. Miller, A. Saiani, J. E. Gough and R. V. Ulijn, Adv. Mater., 2006, 18, 611-614.
    • 6 J. B. Matson and S. I. Stupp, Chem. Commun., 2012, 48, 26-33.
    • 7 G. Laverty, A. P. McCloskey, B. F. Gilmore, D. S. Jones, J. Zhou and B. Xu, Biomacromolecules, 2014, 15, 3429-3439.
    • 8 D. Buenger, F. Topuz and J. Groll, Prog. Polym. Sci., 2012, 37, 1678-1719.
    • 9 F. Rodriguez-Llansola, J. F. Miravet and B. Escuder, Chem. Commun., 2009, 7303-7305.
    • 10 J. Ryu, S.-W. Kim, K. Kang and C. B. Park, Adv. Mater., 2010, 22, 5537-5541.
    • 11 J. Raeburn, A. Zamith Cardoso and D. J. Adams, Chem. Soc. Rev., 2013, 42, 5143-5156.
    • 12 S. Fleming and R. V. Ulijn, Chem. Soc. Rev., 2014, 43, 8150-8177.
    • 13 D. J. Adams, Macromol. Biosci., 2011, 11, 160-173.
    • 14 A. Dasgupta, J. H. Mondal and D. Das, RSC Adv., 2013, 3, 9117-9149.
    • 15 R. Vegners, I. Shestakova, I. Kalvinsh, R. M. Ezzell and P. A. Janmey, J. Pept. Sci., 1995, 1, 371-378.
    • 16 A. Mahler, M. Reches, M. Rechter, S. Cohen and E. Gazit, Adv. Mater., 2006, 18, 1365-1370.
    • 17 D. J. Adams, M. F. Butler, W. J. Frith, M. Kirkland, L. Mullen and P. Sanderson, Soft Matter, 2009, 5, 1856-1862.
    • 18 L. Chen, G. Pont, K. Morris, G. Lotze, A. Squires, L. C. Serpell and D. J. Adams, Chem. Commun., 2011, 47, 12071-12073.
    • 19 Z. Yang, G. Liang and B. Xu, Acc. Chem. Res., 2008, 41, 315-326.
    • 20 S. Roy, N. Javid, P. W. J. M. Frederix, D. A. Lamprou, A. J. Urquhart, N. T. Hunt, P. J. Halling and R. V. Ulijn, Chem. - Eur. J., 2012, 18, 11723-11731.
    • 21 T. Li, M. Kalloudis, A. Z. Cardoso, D. J. Adams and P. S. Clegg, Langmuir, 2014, 30, 13854-13860.
    • 22 S. Fleming, S. Debnath, P. W. J. M. Frederix, N. T. Hunt and R. V. Ulijn, Biomacromolecules, 2014, 15, 1171-1184.
    • 23 T. Li, F. Nudelman, J. W. Tavacoli, H. Vass, D. J. Adams, A. Lips and P. S. Clegg, Adv. Mater. Interfaces, DOI: 10.1002/ admi.1500601.
    • 24 L. Chen, S. Revel, K. Morris, L. C. Serpell and D. J. Adams, Langmuir, 2010, 26, 13466-13471.
    • 25 L. Chen, T. O. McDonald and D. J. Adams, RSC Adv., 2013, 3, 8714-8720.
    • 26 M. Wallace, A. Z. Cardoso, W. J. Frith, J. A. Iggo and D. J. Adams, Chem. - Eur. J., 2014, 20, 16484-16487.
    • 27 H. Cui, M. J. Webber and S. I. Stupp, Pept. Sci., 2010, 94, 1-18.
    • 28 T. Shimada, N. Sakamoto, R. Motokawa, S. Koizumi and M. Tirrell, J. Phys. Chem. B, 2012, 116, 240-243.
    • 29 I. W. Hamley, Soft Matter, 2011, 7, 4122-4138.
    • 30 M. Wallace, D. J. Adams and J. A. Iggo, Soft Matter, 2013, 9, 5483-5491.
    • 31 D. K. Chattoraj and K. S. Birdi, Adsorption and the Gibbs Surface Excess, Plenum Press, New York, 1984.
    • 32 J.-S. Kim, C.-K. Kim, P.-S. Song and K.-M. Lee, J. Colloid Interface Sci., 1981, 80, 294-296.
    • 33 J. N. Israelachvili, Intermolecular and surface forces, Academic Press, Burlington, 2011.
    • 34 M. C. Moran, A. Pinazo, L. Perez, P. Clapes, M. Angelet, M. T. Garcia, M. P. Vinardell and M. R. Infante, Green Chem., 2004, 6, 233-240.
    • 35 S. Zhang, M. A. Greenfield, A. Mata, L. C. Palmer, R. Bitton, J. R. Mantei, C. Aparicio, M. O. de la Cruz and S. I. Stupp, Nat. Mater., 2010, 9, 594-601.
    • 36 M. Guvendiren, H. D. Lu and J. A. Burdick, Soft Matter, 2012, 8, 260-272.
    • 37 S. Tsonchev, K. L. Niece, G. C. Schatz, M. A. Ratner and S. I. Stupp, J. Phys. Chem. B, 2008, 112, 441-447.
    • 38 S. Banta, I. R. Wheeldon and M. Blenner, Annu. Rev. Biomed. Eng., 2010, 12, 167-186.
    • 39 J. Raeburn, C. Mendoza-Cuenca, B. N. Cattoz, M. A. Little, A. E. Terry, A. Zamith Cardoso, P. C. Griffiths and D. J. Adams, Soft Matter, 2015, 11, 927-935.
    • 40 http://www.nist.gov/data/nsrds/NSRDS-NBS361.pdf.
    • 41 Z. Lin, J. J. Cai, L. E. Scriven and H. T. Davis, J. Phys. Chem., 1994, 98, 5984-5993.
    • 42 J. T. Pelton and L. R. McLean, Anal. Biochem., 2000, 277, 167-176.
    • 43 X. Mu, K. M. Eckes, M. M. Nguyen, L. J. Suggs and P. Ren, Biomacromolecules, 2012, 13, 3562-3571.
    • 44 K. M. Eckes, X. Mu, M. A. Ruehle, P. Ren and L. J. Suggs, Langmuir, 2014, 30, 5287-5296.
    • 45 K. L. Morris, L. Chen, A. Rodger, D. J. Adams and L. C. Serpell, Soft Matter, 2015, 11, 1174-1181.
    • 46 K. Harald, L. Judith, O. Jos and D. Otto, Astrophys. J., Lett., 2009, 706, L66.
    • 47 D. M. Hudgins, S. A. Sandford and L. J. Allamandola, J. Phys. Chem., 1994, 98, 4243-4253.
    • 48 J.-B. Guilbaud and A. Saiani, Chem. Soc. Rev., 2011, 40, 1200-1210.
    • 49 D. J. Pochan, L. Pakstis, B. Ozbas, A. P. Nowak and T. J. Deming, Macromolecules, 2002, 35, 5358-5360.
    • 50 R. A. Hule, R. P. Nagarkar, A. Altunbas, H. R. Ramay, M. C. Branco, J. P. Schneider and D. J. Pochan, Faraday Discuss., 2008, 139, 251.
    • 51 R. A. Hule, R. P. Nagarkar, B. Hammouda, J. P. Schneider and D. J. Pochan, Macromolecules, 2009, 42, 7137-7145.
    • 52 K. L. Morris, L. Chen, J. Raeburn, O. R. Sellick, P. Cotanda, A. Paul, P. C. Griffiths, S. M. King, R. K. O'Reilly, L. C. Serpell and D. J. Adams, Nat. Commun., 2013, 4, 1480.
    • 53 C. Colquhoun, E. R. Draper, E. G. B. Eden, B. N. Cattoz, K. L. Morris, L. Chen, T. O. McDonald, A. E. Terry, P. C. Griffiths, L. C. Serpell and D. J. Adams, Nanoscale, 2014, 6, 13719-13725.
    • 54 M. N. Triba, D. E. Warschawski and P. F. Devaux, Biophys. J., 2006, 88, 1887-1901.
    • 55 S. Sathaye, A. Mbi, C. Sonmez, Y. Chen, D. L. Blair, J. P. Schneider and D. J. Pochan, Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol., 2015, 7, 34-68.
    • 56 www.sasview.org.
    • 57 L. A. Feigin and D. I. Svergun, Structure Analysis by Small-Angle X-Ray and Neutron Scattering, Plenum Press, New York, 1987.
    • 58 J. S. Pedersen and P. Schurtenberger, Macromolecules, 1996, 29, 7602-7612.
    • 59 W.-R. Chen, P. D. Butler and L. J. Magid, Langmuir, 2006, 22, 6539-6548.
  • No related research data.
  • No similar publications.

Share - Bookmark

Funded by projects

Cite this article