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Pertusati, Fabrizio; McGuigan, Christopher (2015)
Publisher: RSC Publishing
Languages: English
Types: Article
Subjects: QD, RM

Classified by OpenAIRE into

mesheuropmc: inorganic chemicals
The first copper-catalysed diastereoselective synthesis of P-chiral phosphoramidate prodrugs (ProTides) is reported. This procedure allows the synthesis of diastereomeric-enriched mixtures of ProTides. Application of this methodology to the asymmetric phosphorylation of purine and pyrimidine nucleoside analogues is presented.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1 L. P. Jordheim, D. Durantel, F. Zoulim and C. Dumontet, Nat. Rev. Drug Discov., 2013, 12, 447-464.
    • 2 (a) S. J. Hecker and M. D. Erion, J. Med. Chem., 2008, 51, 2328-2345; (b) L. W. Peterson and C. E. McKenna, Expert Opin. Drug Delivery, 2009, 6, 405-420.
    • 3 (a) C. McGuigan, P. Murziani, M. Slusarczyk, B. Gonczy, J. Vande Voorde, S. Liekens and J. Balzarini, J. Med. Chem., 2011, 54, 7247-7258; (b) M. Slusarczyk, M. H. Lopez, J. Balzarini, M. Mason, G. W. Jiang, S. Blagden, E. Thompson, E. Ghazaly and C. McGuigan, J. Med. Chem., 2014, 57, 1531-1542; (c) K. S. Toti, M. Derudas, F. Pertusati, D. Sinnaeve, F. Van den Broeck, L. Margamuljana, J. C. Martins, P. Herdewijn, J. Balzarini, C. McGuigan and S. Van Calenbergh, J. Org. Chem., 2014, 79, 5097-5112; (d) C. McGuigan, M. Derudas, B. Gonczy, K. Hinsinger, S. Kandil, F. Pertusati, M. Serpi, R. Snoeck, G. Andrei, J. Balzarini, T. D. McHugh, A. Maitra, E. Akorli, D. Evangelopoulos and S. Bhakta, Bioorg. Med. Chem., 2014, 22, 2816-2824; (e) W. Wu and R. F. Borch, Mol. Pharmacol., 2006, 3, 451-456; ( f ) W. Wu, J. Sigmond, G. J. Peters and R. F. Borch, J. Med. Chem., 2007, 50, 3743-3746; (g) F. Pertusati, K. Hinsinger, A´. S. Flynn, N. Powell, A. Tristram, J. Balzarini and C. McGuigan, Eur. J. Med. Chem., 2014, 78, 259-268.
    • 4 ''Approval of Sovaldi (Sofosbuvir) tablets for the treatment of chronic hepatitis C''. FDA. 7 Dec 2013. Retrieved 9 June 2014.
    • 5 http://clinicaltrials.gov/ct2/show/NCT01621854?term=nuc1031&rank=3.
    • 6 http://clinicaltrials.gov/ct2/show/NCT01497899?term=gs7340&rank=3.
    • 7 D. R. Phillips, M. Uramoto, K. Isono and J. A. McCloskey, J. Org. Chem., 1993, 58, 854-859.
    • 8 M. E. Tate, P. J. Murphy, W. P. Roberts and A. Kerr, Nature, 1979, 280, 697.
    • 9 M. Serpi, K. Madela, F. Pertusati and M. Slusarczyk, Synthesis of nucleotide prodrugs using the proTide approach, in Curr. Protoc. Nucleic Acid Chem., John Wiley & Sons, Inc., 2013, vol. 53, pp. 15.5.1-15.5.15.
    • 10 (a) M. K. H. Chapman, E. Prisbe, J. Rohloff, M. Sparacino, T. Terhorst and R. Yu, Nucleosides, Nucleotides Nucleic Acids, 2001, 20, 621-625; (b) M. J. Sofia, D. Bao, W. Chang, J. Du, D. Nagarathnam, S. Rachakonda, P. G. Reddy, B. S. Ross, P. Wang, H.-R. Zhang, S. Bansal, C. Espiritu, M. Keilman, A. M. Lam, H. M. M. Steuer, C. Niu, M. J. Otto and P. A. Furman, J. Med. Chem., 2010, 53, 7202-7218; (c) A. Cho, L. Zhang, J. Xu, R. Lee, T. Butler, S. Metobo, V. Aktoudianakis, W. Lew, H. Ye, M. Clarke, E. Doerffler, D. Byun, T. Wang, D. Babusis, A. C. Carey, P. German, D. Sauer, W. Zhong, S. Rossi, M. Fenaux, J. G. McHutchison, J. Perry, J. Feng, A. S. Ray and C. U. Kim, J. Med. Chem., 2013, 57, 1812-1825.
    • 11 (a) N. Mesplet, Y. Saito, P. Morin and L. A. Agrofoglio, J. Chromatogr. A, 2003, 983, 115-124; (b) C. J. Allender, K. R. Brain, C. Ballatore, D. Cahard, A. Siddiqui and C. McGuigan, Anal. Chim. Acta, 2001, 435, 107-113.
    • 12 (a) J. B. C. Arbelo Roman and C. Meier, J. Med. Chem., 2010, 53, 7675; (b) C. Arbelo Rom´an, P. Wasserthal, J. Balzarini and C. Meier, Eur. J. Org. Chem., 2011, 4899.
    • 13 P. G. Reddy, B.-K. Chun, H.-R. Zhang, S. Rachakonda, B. S. Ross and M. J. Sofia, J. Org. Chem., 2011, 76, 3782-3790.
    • 14 S. Jones and D. Selitsianos, Org. Lett., 2002, 4, 3671-3673.
    • 15 C. McGuigan, K. Madela, M. Aljarah, A. Gilles, A. Brancale, N. Zonta, S. Chamberlain, J. Vernachio, J. Hutchins, A. Hall, B. Ames, E. Gorovits, B. Ganguly, A. Kolykhalov, J. Wang, J. Muhammad, J. M. Patti and G. Henson, Bioorg. Med. Chem. Lett., 2010, 20, 4850-4854.
    • 16 S. Jones and C. Smanmoo, Org. Lett., 2005, 7, 3271-3274.
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