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Pertusati, Fabrizio; McGuigan, Christopher (2015)
Publisher: RSC Publishing
Languages: English
Types: Article
Subjects: QD, RM

Classified by OpenAIRE into

mesheuropmc: inorganic chemicals
The first copper-catalysed diastereoselective synthesis of P-chiral phosphoramidate prodrugs (ProTides) is reported. This procedure allows the synthesis of diastereomeric-enriched mixtures of ProTides. Application of this methodology to the asymmetric phosphorylation of purine and pyrimidine nucleoside analogues is presented.
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