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Scott, JPR; Sale, C; Greeves, JP; Casey, A; Dutton, J; Fraser, WD (2012)
Publisher: Elsevier
Languages: English
Types: Article
Subjects:
Individuals often perform exercise in the fasted state, but the effects on bone metabolism are not currently known. We compared the effect of an overnight fast with feeding a mixed meal on the bone metabolic response to treadmill running. Ten, physically-active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% V02max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before and during exercise, for 3h after exercise, and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for the c-terminal telopeptide region of collagen type 1 (P-CTX), n-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone alkaline phosphatase (bone ALP), parathyroid hormone (PTH), albumin-adjusted calcium, phosphate, osteoprotegerin (OPG), Cortisol, leptin and ghrelin.
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    • [1] K . Van Proyen, K . Szlufcik, H . Nielens, M . Ramaekers, P. Hespel. Beneficial metabolic adaptations due to endurance exercise training in the fasted state. J. Appl. Physiol. 110 (2011) 236-245.
    • [2] E.F. Coyle, A.R. Coggan, M . K . Hemmert, J.L. Ivy. Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J. Appl. Physiol. 61 (1986) 165-172.
    • [3] M . J . Arkinstall, C.R. Bruce, V . Nikolopoulos, A.P Garnham, J.A. Hawley. Effect of carbohydrate ingestion on metabolism during running and cycling. J. Appl. Physiol. 91 (2001)2125-2134.
    • [4] G.R. Cox, S.A. Clark, A . J Cox, S.L. Halson, M . Hargreaves, J.A. Hawley, N . Jeacocke, R.J. Snow, W . K . Yeo, L . M . Burke. Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling. J. Appl. Physiol. 109 (2010)126-134.
    • [5] J.W. Helge, P.W. Watt, E.A. Richter, M . J . Rennie, B. Kiens. Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein-triacylglycerol in humans. J. Physiol. 537 (2001) 1009-1020.
    • [6] L . M . Odland, G.J Heigenhauser, L . L Spriet. Effects of high fat provision on muscle P D H activation and malonyl-CoA content in moderate exercise. J. Appl. Physiol. 89 (2000) 2352- 2358.
    • [7] L . M . Odland, G.J. Heigenhauser, D. Wong, M . G . Hollidge-Horvat, L . L Spriet. Effects of increased fat availability on fat-carbohydrate interaction during prolonged exercise in men. Am. J. Physiol. 274 (1998) R894-902.
    • [8] J.F. Horowitz, R. Mora-Rodriguez, L.O. Byerley, E.F. Coyle. Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise. Am. J. Physiol. 273 (1997)E768-775.
    • [9] R.J. Maughan, J. Fallah, E.F. Coyle. The effects of fasting on metabolism and performance. Brit. J. Sp. Med. 44 (2010) 490-494.
    • [10] N . H . Bjarnason, E.E. Henriksen, P. Alexandersen, S. Christgau, D.B. Henriksen, C. Christiansen. Mechanism of circadian variation in bone resorption. Bone. 30 (2002) 307-313.
    • [11] D.B. Henriksen, P. Alexandersen, N . H . Bjarnason, T. Vilsb0ll, B. Hartmann, E.E. Henriksen, I. Byrjalsen, T. Krarup, J.J. Hoist, C. Christiansen. Role of gastrointestinal hormones in postprandial reduction of bone resorption. J. Bone. Miner. Res. 18 (2003) 2180- 2189.
    • [12] J.J Hoist, B. Hartmann, LB. Gottschalck, P.B. Jeppesen, J. Miholic, D.B. Henriksen. Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate. Scand. J. Gastroenterol. 42 (2007) 814-820.
    • [13] J.A. Clowes, H.C. Allen, D . M . Prentis, R. Eastell, A. Blumsohn. Octreotide abolishes the acute decrease in bone turnover in response to oral glucose. J. Clin. Endocrinol. Metab. 88(2003)4867-4873.
    • [14] J.A. Clowes, T.S. Yap, J. L i , N . Hoyle, A. Blumsohn, R.A.Hannon, R. Eastell. The effect of feeding on bone turnover markers and its impact on biological variability of measurements. Bone. 30 (2002) 886-890.
    • [15] J. Guillemant, C. Accarie, G. Peres, S. Guillemant. Acute effects of an oral calcium load on markers of bone metabolism during endurance cycling exercise in male athletes. Calcif. Tissue. Int. 74 (2004) 407-414.
    • [16] M . Herrmann, M . Muller, J. Scharhag, M . Sand-Hill, W. Kindermann, W. Herrmann. The effect of endurance exercise-induced lactacidosis on biochemical markers of bone turnover. Clin. Chem. Lab. Med. 45 (2007) 1381-1389.
    • [17] K . Kerschan-Schindl, M . Thalmann, G.H Sodeck, K. Skenderi, A . L . Matalas, S. Grampp, C. Ebner, P. Pietschmann. A 246-km continuous running race causes significant changes in bone metabolism. Bone. 45 (2009) 1079-1083.
    • [18] L. Maimoun, J. Manetta, I. Couret, A . M . Dupuy, D. Mariano-Goulart, J.P. Micallef, E. Peruchon, M . Rossi. The intensity level of physical exercise and the bone metabolism response. Int. J. Sports. Med. 27 (2006) 105-111.
    • [19] J.P.R. Scott, C. Sale, J.P Greeves, A. Casey, J. Dutton, W.D. Fraser. The effects of training status on the metabolic response of bone to an acute bout of exhaustive treadmill running. J. Clin. Endocrinol. Metab. 95 (2010) 3918-3925.
    • [20] M . B . Schaffler, E.L. Radin, D.B. Burr. Long-term fatigue behaviour of compact bone at low strain magnitude and rate. Bone. 11 (1990) 321-326.
    • [21] P. Garnero, E. Sornay-Rendu, M . C . Chapuy, P.D. Delmas. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J. Bone. Miner. Res. 11 (1996) 337-349.
    • [22] K. Bennell, S. Malcolm, S. Thomas, J. Wark, P. Brukner. The incidence and distribution of stress fractures in competitive track and field athletes: A twelve-month prospective study. Am. J. Sports. Med. 24 (1996) 211-217.
    • [23] A.D. Stewart, J. Hannan. Total and regional bone density in male runners, cyclists, and controls. Med. Sci. Sports. Exerc. 32 (2000) 1373-1377.
    • [24] K. Hind, J.G. Truscott, J.A. Evans. Low lumbar spine bone mineral density in both male and female endurance runners. Bone. 39 (2006) 880-885.
    • [25] J. Lappe, D. Cullen, G. Haynatzki, R. Recker, R. Ahlf, K. Thompson. Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits. J. Bone Miner. Res. 23 (2008) 741-749.
    • [26] D.W. Barry, W . M . Kohrt. B M D decreases over the course of a year in competitive male cyclists. J. Bone. Miner. Res. 23 (2008) 484-491.
    • [27] R.S. Rogers, A . W . Dawson, Z. Wang, J.P Thyfault, P S Hinton. Acute response of plasma markers of bone turnover to a single-bout of resistance-training or plyometrics. J. Appl. Physiol. I l l (2011) 1353-1360.
    • [28] J.P.R. Scott, C. Sale, J.P Greeves, A. Casey, J. Dutton, W.D. Fraser. Comment on Rogers et al. Acute response of plasma markers of bone turnover to a single-bout of resistance-training or plyometrics. J. Appl. Physiol. 112 (2012) 328-329.
    • [29] J.P. Rissanen, M.I. Suominen, Z. Peng, J . M . Halleen. Secreted tartrateresistant acid phosphatase 5b is a marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model. Calcif Tissue. Int. 82 (2008) 108-115.
    • [30] G. Banfi, G. Lombardi, A. Colombini, G. Lippi G. Bone metabolism markers in sports medicine. Sports. Med. 40 (2010) 697-714.
    • [31] J.P.R. Scott, C. Sale, J.P. Greeves, A. Casey, J. Dutton, W.D. Fraser. The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise. J. Appl. Physiol. 110 (2011) 423-432.
    • [32] J. Erdmann, F. Lippl, S. Wagenpfeil, V. Schusdziarra. Differential association of basal and postprandial plasma ghrelin with leptin, insulin, and type 2 diabetes. Diabetes. 54 (2005) 1371-1378.
    • [33] J. Dallongeville, B. Hecquet, P. Lebel, J-L. Edme, C. Le Fur, J-C. Fruchart, J. Auwerx, M . Romon. Short term response of circulating leptin to feeding and fasting in man: influence of circadian cycle. Int. J. Obesity. 22 (1998) 728-733.
    • [34] J.L. Olive, G.D. Miller. Differential effects of maximal- and moderate-intensity runs on plasma leptin in healthy trained subjects. Nutrition. 17 (2001) 365-9.
    • [35] E.T. Vestergaard, R. Dall, K . H . Lange, M . Kjaer, J.S. Christiansen, J.O. Jorgensen. The ghrelin response to exercise before and after growth hormone administration. J. Clin. Endocrinol. Metab 92 (2007) :297-303.
    • [36] N . Fukushima, R. Hanada, H . Teranishi, Y . Fukue, T. Tachibana, H . Ishikawa, S. Takeda, Y . Takeuchi, S. Fukumoto, K . Kangawa, K. Nagata, M . Kojima. J. Bone. Miner. Res. 20 (2005) 790-8.
    • [37] T. Thomas. The complex effects of leptin on bone metabolism through multiple pathways. Curr. Opin. Pharmacol. 4 (2004) 295-300.
    • [39] R.J. Maughan. Fasting and sport: an introduction. Brit. J. Sp. Med. 44 (2010) 473-474.
    • [41] J. Guillemant, H.T. Le, C. Accarie, S.T. du Montcel, A . M . Delabroise, M . J . Arnaud, S. Guillemant. Mineral water as a source of dietary calcium: acute effects on parathyroid function and bone resorption in young men. Am. J. Clin. Nutr. 71 (2000) 999-1002.
    • [42] V. Zikan, T. Haas, J.J. Stepan. Acute effects in healthy women of oral calcium on the calcium-parathyroid axis and bone resorption as assessed by serum beta-CrossLaps. Calcif. Tissue. Int. 68 (2001) 352-357.
    • [43] D.W. Barry, R.E. Van Pelt, K.C. Hansen, M . Witten, P. Wolfe, W. M . Kohrt. Acute calcium ingestion attenuates exercise-induced disruption of calcium homeostasis. Med. Sci. Sports. Exerc. 43 (2011) 617-623.
    • [44] J.S. Walsh, D.B. Henriksen. Feeding and bone. Arch. Biochem. Biophys. 503 (2010) 11-19.
    • [45] A . M . O'Connor, S. Pola, B. M . Ward, D. Fillmore, K . D . Buchanan, J.P. Kirwan. The gastroenteroinsular response to glucose ingestion during postexercise recovery. Am. J. Physiol. 290 (2006) E l 155-1161.
    • [46] S.Y. Ueda, T. Yoshikawa, Y . Katsura, T. Usui, S. Fujimoto. Comparable effects of moderate intensity exercise on changes in anorectic gut hormone levels and energy intake to high intensity exercise. J. Endocrinol. 203 (2009a) 357-364.
    • [47] S.Y. Ueda, T. Yoshikawa, Y . Katsura, T. Usui, H . Nakao, S. Fujimoto. Changes in gut hormone levels and negative energy balance during aerobic exercise in obese young males. J. Endocrinol. 201 (2009b) 151-159.
    • [52] R . M . Crameri, H . Langberg, B. Teisner, P. Magnusson, H.D. Schrader, J.L. Olesen, C.H. Jensen, S. Koskinena, C. Suetta, M . Kjaer. Enhanced procollagen processing in skeletal muscle after a single bout of eccentric loading in humans. Matrix. Biol. 23 (2004) 259-264.
    • [53] B.F. Miller, M . Hansen, J.L. Olesen, P. Schwarz, J.A. Babraj, K. Smith, M.J. Rennie, M . Kjaer. Tendon collagen synthesis at rest and after exercise in women. J. Appl. Physiol. 102 (2007)541-546.
    • [54] J. Melkko, T. Hellevik, L. Risteli, J. Risteli, B. Smedsrod. Clearance of NH2-terminal propeptides of types I and III procollagen is a physiologic function of the scavenger receptor in liver endothelial cells. J. Exp. Med. 179 (1994) 405-412.
    • [55] A.G. Robling, F . M . Hinant, D.B. Burr, C.H. Turner. Shorter, more frequent mechanical loading sessions enhance bone mass. Med. Sci. Sports. Exerc. 34 (2002) 196-202.
    • [56] L.O. Chailurkit, S. Chanprasertyothin, R. Rajatanavin, B. Ongphiphadhanakul. Reduced attenuation of bone resorption after oral glucose in type 2 diabetes. Clin. Endocrinol. (Oxf). 68 (2008)858-862.
    • [57] G.M. J0rgensen, B. Vind, M . Nybo, L . M . Rasmussen, K. H0Jlund. Acute hyperinsulinemia decreases plasma osteoprotegerin with diminished effect in type 2 diabetes and obesity. Eur. J. Endocrinol. 161 (2009) 95-101.
    • [58] S. Ziegler, A. Niessner, B. Richter, S. Wirth, E. Billensteiner, W. Woloszczuk, J. Slany, G. Geyer. Endurance running acutely raises plasma osteoprotegerin and lowers plasma receptor activator of nuclear factor kappa B ligand. Metabolism. 54 (2005) 935-938.
    • [59] D. Hegedus, V. Ferencz, P.L. Lakatos, S. Meszaros, P. Lakatos, C. Horvath, F. Szalay. Decreased bone density, elevated serum osteoprotegerin, and beta-cross-laps in Wilson disease. J. Bone. Miner. Res. 17 (2002) 1961-1967.
    • [60] V. Zikan, J.J. Stepan. Marker of bone resorption in acute response to exogenous or endogenous parathyroid hormone. Biomark. Insights. 25 (2008) 19-24.
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