LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Martin, Natasha K.; Thornton, Alicia; Hickman, Matthew; Sabin, Caroline; Nelson, Mark; Cooke, Graham S.; Martin, Thomas C.S.; Delpech, Valerie; Ruf, Murad; Price, Huw; Azad, Yusef; Thomson, Emma C.; Vickerman, Peter (2016)
Publisher: Oxford University Press
Journal: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Languages: English
Types: Article
Subjects: Articles and Commentaries, /dk/atira/pure/publication/pubmedpublicationtype/D052061, 06 Biological Sciences, Microbiology, /dk/atira/pure/publication/pubmedpublicationtype/D013485, men who have sex with men, Research Support, Non-U.S. Gov't, hepatitis C virus, antiviral treatment, HIV, Research Support, N.I.H., Extramural, 11 Medical And Health Sciences, /dk/atira/pure/publication/pubmedpublicationtype/D016428, Journal Article, prevention

Classified by OpenAIRE into

mesheuropmc: virus diseases

Background. We report on the hepatitis C virus (HCV) epidemic among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in the United Kingdom and model its trajectory with or without scaled-up HCV direct-acting antivirals (DAAs).

Methods. A dynamic HCV transmission model among HIV-diagnosed MSM in the United Kingdom was calibrated to HCV prevalence (antibody [Ab] or RNA positive), incidence, and treatment from 2004 to 2011 among HIV-diagnosed MSM in the UK Collaborative HIV Cohort (UK CHIC). The epidemic was projected with current or scaled-up HCV treatment, with or without a 20% behavioral risk reduction.

Results. HCV prevalence among HIV-positive MSM in UK CHIC increased from 7.3% in 2004 to 9.9% in 2011, whereas primary incidence was flat (1.02-1.38 per 100 person-years). Over the next decade, modeling suggests 94% of infections are attributable to high-risk individuals, comprising 7% of the population. Without treatment, HCV chronic prevalence could have been 38% higher in 2015 (11.9% vs 8.6%). With current treatment and sustained virological response rates (status quo), chronic prevalence is likely to increase to 11% by 2025, but stabilize with DAA introduction in 2015. With DAA scale-up to 80% within 1 year of diagnosis (regardless of disease stage), and 20% per year thereafter, chronic prevalence could decline by 71% (to 3.2%) compared to status quo in 2025. With additional behavioral interventions, chronic prevalence could decline further to <2.5% by 2025.

Conclusions. Epidemiological data and modeling suggest a continuing HCV epidemic among HIV-diagnosed MSM in the United Kingdom driven by high-risk individuals, despite high treatment rates. Substantial reductions in HCV transmission could be achieved through scale-up of DAAs and moderately effective behavioral interventions.

  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Urbanus AT, van de Laar TJ, Stolte IG, et al. Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS 2009; 23:F1-7.
    • 2. van de Laar T, Pybus O, Bruisten S, et al. Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men. Gastroenterology 2009; 136:1609-17.
    • 3. Price H, Gilson R, Mercey D, et al. Hepatitis C in men who have sex with men in London-a community survey. HIV Med 2013; 14:578-80.
    • 4. Yaphe S, Bozinoff N, Kyle R, Shivkumar S, Pai N, Klein M. Incidence of acute hepatitis C virus infection among men who have sex with men with and without HIV infection: a systematic review. Sex Trans Infect 2012; 88:558-64.
    • 5. Giraudon I, Ruf M, Maguire H, et al. Increase in diagnosed newly acquired hepatitis C in HIV-positive men who have sex with men across London and Brighton, 2002-2006: is this an outbreak? Sex Transm Infect 2008; 84:111-6.
    • 6. Ruf M, Delpech V, Osuagwu U, Brown A, Robinson E, Chadborn T. Men who have sex with men: estimating the size of at-risk populations in London primary care trusts. Int J STD AIDS 2011; 22:25-9.
    • 7. Martin NK, Vickerman P, Grebely J, et al. HCV treatment for prevention among people who inject drugs: modeling treatment scale-up in the age of direct-acting antivirals. Hepatology 2013; 58:1598-609.
    • 8. Martin NK, Miners A, Vickerman P, et al. The cost-effectiveness of HCV antiviral treatment for injecting drug user populations. Hepatology 2012; 55:49-57.
    • 9. Martin NK, Vickerman P, Foster GR, Hutchinson SJ, Goldberg DJ, Hickman M. Can antiviral therapy for hepatitis C reduce the prevalence of HCV among injecting drug user populations? A modelling analysis of its prevention utility. J Hepatol 2011; 54:1137-44.
    • 10. Martin NK, Vickerman P, Dore GJ, Hickman M. The hepatitis C virus epidemics in key populations (including people who inject drugs, prisoners and MSM): the use of direct-acting antivirals as treatment for prevention. Curr Opin HIV AIDS 2015; 10:374-80.
    • 11. Wyles D, Ruane P, Sulkowski M, et al. Daclatasvir in combination with sofosbuvir for HIV/HCV coinfection: ALLY-2 study. In: Conference on Retroviruses and Opportunistic Infections, Seattle, WA, 23-24 February 2015. Abstract 151LB.
    • 12. Naggie S, Cooper C, Saag M, et al. Ledipasvir/sofosbuvir for 12 weeks in patients coinfected with HCV and HIV-1. In: Conference on Retroviruses and Opportunistic Infections, Seattle, WA, 23-24 February 2015. Abstract 152LB.
    • 13. Lambers F, Prins M, Thomas M, et al. Alarming incidence of hepatitis C virus reinfection after treatment of sexually acquired acute hepatitis C virus infection in HIV-infected MSM. AIDS 2011; 25:F21-7.
    • 14. Martin T, Martin N, Hickman M, et al. HCV reinfection incidence and treatment outcome among HIV-positive MSM in London. AIDS 2013; 27:255107.
    • 15. Simmons B, Saleem J, Hill A, Riley R, Cooke G. Risk of late relapse or reinfection with hepatitis C virus after achieving a sustained virological response: a systematic review and meta-analysis. Clin Infect Dis 2016; 62:683-94.
    • 16. The UK Collaborative HIV Cohort (UKCHIC) Steering Committee. The creation of a large UK-based multicentre cohort of HIV-infected individuals: the UK Collaborative HIV Cohort (UK CHIC) Study. HIV Med 2004; 5:115-24.
    • 17. Fierer D, Factor S, Uriel A, et al. Sexual transmission of hepatitis C virus among HIV-infected men who have sex with men-New York City 2005-2010. MMWR Morb Mortal Wkly Rep 2011; 60:945-50.
    • 18. Danta M, Brown D, Bhagani S, et al. Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. AIDS 2007; 21:983-91.
    • 19. Vogel M, Van De Laar T, Kupfer B, et al. Phylogenetic analysis of acute hepatitis C virus genotype 4 infections among human immunodeficiency virus-positive men who have sex with men in Germany. Liver Int 2010; 30:1169-72.
    • 20. Public Health England. HIV in the United Kingdom: 2014 report. 2014.
    • 21. Health Protection Agency. Sexually transmitted infections in men who have sex with men in the UK: 2011 report. 2011. Available at: http://webarchive. nationalarchives.gov.uk/20140714084352/http://www.hpa.org.uk/webc/HPAweb File/HPAweb_C/1317131685989. Accessed 20 February 2016.
    • 22. Davies A, Singh KP, Shubber Z, et al. Treatment outcomes of treatment-naive hepatitis C patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts. PLoS One 2013; 8:e55373.
    • 23. May M, Gompels M, Delpech V, et al. Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) study. 2011; doi:10.1136/bmj.d6016.
    • 24. van der Helm J, Geskus R, Sabin C, et al. Effect of HCV infection nn cause-specific mortality following HIV seroconversion before and after 1997. Gastroenterology 2013; 144:751-60.e2.
    • 25. Weber R, Sabin C, Friis-Møller N, et al. Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study. Arch Intern Med 2006; 166:1632-41.
    • 26. Turner JM, Rider AT, Imrie J, et al. Behavioural predictors of subsequent hepatitis C diagnosis in a UK clinic sample of HIV positive men who have sex with men. Sex Transm Infect 2006; 82:298-300.
    • 27. van der Helm J, Prins M, del Amo J, et al. The hepatitis C epidemic among HIV-positive MSM: incidence estimates from 1990 to 2007. AIDS 2011; 25: 1083-91.
    • 28. Wandeler G, Gsponer T, Bregenzer A, et al. Hepatitis C virus infections in the Swiss HIV Cohort Study: a rapidly evolving epidemic. Clin Infect Dis 2012; 55:1408-16.
    • 29. Vanhommerig J. Stabilizing incidence of hepatitis C virus infection among men who have sex with men in Amsterdam. In: Conference of the European Association for the Study of the Liver, 2014. Oral abstract.
    • 30. Witt M, Seaberg EC, Darilay A, et al. Incident hepatitis C virus infection in men who have sex with men: a prospective cohort analysis, 1984-2011. Clin Infect Dis 2013; 57:77-84.
    • 31. Johnson W, Diaz R, Flanders W, et al. Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men. Cochrane Database Syst Rev 2008; doi:10.1002/14651858.CD001230.pub2.
    • 32. Turner KM, Hutchinson S, Vickerman P, et al. The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence. Addiction 2011; 106:1978-88.
    • 33. European Association for the Study of the Liver. EASL recommendations on treatment of hepatitis C 2015. Available at: http://www.easl.eu/research/ourcontributions/clinical-practice-guidelines/detail/recommendations-on-treatmentof-hepatitis-c-2015.
    • 34. American Association for the Study of Liver Diseases/Infectious Diseases Society of America. Recommendations for testing, managing, and treating hepatitis C. Available at: http://www.hcvguidelines.org/fullreport.
  • No related research data.
  • No similar publications.

Share - Bookmark

Funded by projects

  • NIH | Center for AIDS Research
  • WT | T cell mediated evolution of...
  • NIH | Modeling Structural HIV Det...

Cite this article