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Burke, Philip; Chun Wong, Lai; Jenkins, Terence; Knox, Richard; Meikle, Ian; Stanforth, Stephen (2016)
Publisher: Elsevier
Languages: English
Types: Article
Subjects: C700
A series of N-nitroarylated-3-chloromethyl-1,2,3,4-tetrahydroisoquinoline derivatives, several of which also possessed a trifluoromethyl substituent, were prepared and assessed as potential nitroaromatic prodrugs. The enzymatic reduction of these compounds and their cytotoxicities were studied. The compounds were cytotoxic, but this is probably not related to their enzymatic reduction.
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