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Ruane, Karen M.; Lloyd, Adrian J.; Fülöp, Vilmos; Dowson, Christopher G.; Barreteau, Hélène; Boniface, Audrey; Dementin, Sébastien; Blanot, Didier; Mengin-Lecreulx, Dominique; Gobec, Stanislav; Dessen, Andréa; Roper, David I. (2013)
Publisher: American Society for Biochemistry and Molecular Biology
Languages: English
Types: Article
Subjects: QR, QH301

Classified by OpenAIRE into

mesheuropmc: bacteria, complex mixtures
Background: MurE controls stereo chemical incorporation of Lysine or diaminopimelate into peptidoglycan stem peptides\ud \ud Results: The structure of S.aureus MurE reveals an unexpected lack of specificity for Lysine within the active site.\ud \ud Conclusion: Incorporation of Lysine is supported by the comparatively high concentration of cytoplasmic lysine, not enzyme specificity.\ud \ud Significance: This study provides new perspectives in targeting Gram-positive peptidoglycan assembly for antimicrobial discovery.

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