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Wang, Zhipeng; Tan, Jiao; McConville, Christopher; Kannappan, Vinodh; Tawari, Patricia Erebi; Brown, James; Ding, Jin; Armesilla, Angel L.; Irache, Juan M.; Mei, Qi-Bing; Tan, Yuhuan; Liu, Ying; Jiang, Wenguo; Bian, Xiu-Wu; Wang, Weiguang (2017)
Publisher: Elsevier
Journal: Nanomedicine
Languages: English
Types: Article
Subjects: RC0254, Medicine (miscellaneous), PLGA, Pharmaceutical Science, Biomedical Engineering, Disulfiram, Drug delivery, Drug repositioning, Bioengineering, Materials Science(all), Original Article, Molecular Medicine, Liver cancer, Nano-technology, RM, Cancer stem cells

Classified by OpenAIRE into

mesheuropmc: technology, industry, and agriculture, macromolecular substances
Disulfiram (DS), an anti-alcoholism drug, shows very strong cytotoxicity in many cancer types. However its clinical application in cancer treatment is limited by the very short half-life in the bloodstream. In this study, we developed a poly lactic-co-glycolic acid (PLGA)-encapsulated DS protecting DS from the degradation in the bloodstream. The newly developed DS-PLGA was characterized. The DS-PLGA has very satisfactory encapsulation efficiency, drug-loading content and controlled release rate in vitro. PLGA encapsulation extended the half-life of DS from shorter than 2 minutes to 7 hours in serum. In combination with copper, DS-PLGA significantly inhibited the liver cancer stem cell population. CI-isobologram showed a remarkable synergistic cytotoxicity between DS-PLGA and 5-FU or Sorafenib. It also demonstrated very promising anticancer efficacy and antimetastatic effect in liver cancer mouse model. Both DS and PLGA are FDA approved products for clinical application. Our study may lead to repositioning of DS into liver cancer treatment.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

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