LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Jones, William; Allardice, Gwen; Scott, Iona; Oien, Karin; Brewster, David; Morrison, David S. (2017)
Publisher: BioMed Central
Journal: BMC Cancer
Languages: English
Types: Article
Subjects: Occult primary neoplasms, Unknown primary tumor, Genetics, Research Article, Cancer Research, Oncology
Background: \ud Cancers of Unknown Primary (CUP) are the 3-4th most common causes of cancer death and recent clinical guidelines recommend that patients should be directed to a team dedicated to their care. Our aim was to inform the care of patients diagnosed with CUP during hospital admission.\ud \ud Methods: \ud Descriptive study using hospital admissions (Scottish Morbidity Record 01) linked to cancer registrations (ICD-10 C77-80) and death records from 1998 to 2011 in West of Scotland, UK (population 2.4 m). Cox proportional hazards models were used to assess effects of baseline variables on survival.\ud \ud Results: \ud Seven thousand five hundred ninety nine patients were diagnosed with CUP over the study period, 54.4% female, 67.4% aged ≥ 70 years, 36.7% from the most deprived socio-economic quintile. 71% of all diagnoses were made during a hospital admission, among which 88.6% were emergency presentations and the majority (56.3%) were admitted to general medicine. Median length of stay was 15 days and median survival after admission 33 days. Non-specific morphology, emergency admission, age over 60 years, male sex and admission to geriatric medicine were all associated with poorer survival in adjusted analysis.\ud \ud Conclusions: \ud Patients with a diagnosis of CUP are usually diagnosed during unplanned hospital admissions and have very poor survival. To ensure that patients with CUP are quickly identified and directed to optimal care, increased surveillance and rapid referral pathways will be required.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. National Institute for Health and Clinical Excellence: Metastic malignant disease of unknown primary origin: Diagnosis and management of metastatic malignant disease of unknown primary origin. London: NICE; 2010.
    • 2. Shu X, Sundquist K, Sundquist J, Hemminki K. Time trends in incidence, causes of death, and survival of cancer of unknown primary in Sweden. Eur J Cancer Prev. 2012;21(3):281-8.
    • 3. Luke C, Koczwara B, Karapetis C, Pittman K, Price T, Kotasek D, Beckmann K, Brown MP, Roder D. Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: implications for research and clinical care. Aust N Z J Public Health. 2008;32(4):383-9.
    • 4. Urban D, Rao A, Bressel M, Lawrence YR, Mileshkin L. Cancer of unknown primary: a population-based analysis of temporal change and socioeconomic disparities. Br J Cancer. 2013;109(5):1318-24.
    • 5. Randen M, Rutqvist LE, Johansson H. Cancer patients without a known primary: incidence and survival trends in Sweden 1960-2007. Acta Oncol. 2009;48(6):915-20.
    • 6. Pavlidis N, Pentheroudakis G. Cancer of unknown primary site. Lancet. 2012; 379(9824):1428-35.
    • 7. Brewster DH, Lang J, Bhatti LA, Thomson CS, Oien KA. Descriptive epidemiology of cancer of unknown primary site in Scotland, 1961-2010. Cancer Epidemiol. 2014;38(3):227-34.
    • 8. Cancer Research UK and National Cancer Intelligence Network. Cancer of unknown primary NCIN and CR-UK data briefing. 2013.
    • 9. Fizazi K, Greco FA, Pavlidis N, Pentheroudakis G, Group EGW. Cancers of unknown primary site: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2011;22 Suppl 6:vi64-8.
    • 10. National Cancer Intelligence Network. Routes to diagnosis: cancer of unknown primary - NCIN data briefing. 2014.
    • 11. Fritz A, Percy C, Jack A. International Classification of Diseases for Oncology. 3rd edn. Geneva: World Health Organisation; 2000.
    • 12. Scottish Government. http://www.scotland.gov.uk/Topics/Statistics/SIMD/ BackgroundMethodology. Accessed 27 Jan 2017.
    • 13. Greco FA. Cancer of unknown primary site: evolving understanding and management of patients. Clin Adv Hematol Oncol. 2012;10(8):518-24.
    • 14. Pavlidis N, Pentheroudakis G. Cancer of unknown primary site: 20 questions to be answered. Ann Oncol. 2010;21:303-7.
    • 15. Hemminki K, Ji J, Sundquist J, Shu X. Familial risks in cancer of unknown primary: tracking the primary sites. J Clin Oncol. 2011;29(4):435-40.
  • No related research data.
  • No similar publications.

Share - Bookmark

Funded by projects

Cite this article