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Ohuma, E. O.; Okiro, E. A.; Bett, A.; Abwao, John; Were, S.; Samuel, Dhan; Vyse, A. J.; Gay, N. J.; Brown, D. W. G.; Nokes, D. James (2009)
Publisher: Cambridge University Press
Journal: Epidemiology and Infection
Languages: English
Types: Article
Subjects: measles antibodies, Methods, mixture modelling, oral fluid, Campaign vaccination, Original Papers, Kenya, RA
SUMMARY We evaluated the effectiveness of a measles vaccine campaign in rural Kenya, based on oral-fluid surveys and mixture-modelling analysis. Specimens were collected from 886 children aged 9 months to 14 years pre-campaign and from a comparison sample of 598 children aged 6 months post-campaign. Quantitative measles-specific antibody data were obtained by commercial kit. The estimated proportions of measles-specific antibody negative in children aged 0?4, 5?9 and 10?14 years were 51%, 42% and 27%, respectively, pre- campaign and 18%, 14% and 6%, respectively, post-campaign. We estimate a reduction in the proportion susceptible of 65?78%, with ~85% of the population recorded to have received vaccine. The proportion of ?weak? positive individuals rose from 35% pre-campaign to 54% post-campaign. Our results confirm the effectiveness of the campaign in reducing susceptibility to measles and demonstrate the potential of oral-fluid studies to monitor the impact of measles vaccination campaigns.

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