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Gibbins, Jonathan M. (2016)
Publisher: American Society of Hematology
Languages: English
Types: Article
In this issue of Blood, Welsh and colleagues determine how platelet thrombi limit the loss of plasma-borne proteins from the microvasculature. 1\ud \ud The concept that platelets prevent leakage from blood vessels following a penetrating injury will come as little surprise to most readers, but exactly how platelets physically contribute to this process is not well understood. Such injuries result in the loss of blood cells and plasma into the surrounding tissues, and both forms of loss must be halted quickly. Platelets are believed to form the first line of defense in such situations, forming a thrombus that is capable of plugging the hole and supplying molecules that contribute to localized inflammation and wound healing.
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    • Welsh, J.D., R.W. Muthard, T.J. Stalker, J.P. Taliaferro, S.L. Diamond, and L.F. Brass, S systems approach to hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature Blood, 2016. XXX.
    • Falati, S., P. Gross, G. Merrill-Skoloff, B.C. Furie, and B. Furie, Realtime in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med, 2002. 8: 1175-81.
    • Celi, B.C. Furie, and B. Furie, In vivo models of platelet function and thrombosis: study of real-time thrombus formation. Methods Mol Biol, 2004. 272: 187-97.
    • Thromb Haemost, 2011. 105: 776-82.
    • Sage, R.S. Reneman, and M.G. oude Egbrink, Real-time detection of activation patterns in individual platelets during thromboembolism in vivo: differences between thrombus growth and embolus formation. J Vasc Res, 2002. 39: 534-43.
    • Cermignano, R. Voronov, S.L. Diamond, and L.F. Brass, Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood, 2013. 121: 1875-85.
    • Diamond, and L.F. Brass, A systems approach to hemostasis: 3.
    • Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity. Blood, 2014. 124: 1824-31.
    • Tomaiuolo, M., T.J. Stalker, J.D. Welsh, S.L. Diamond, T. Sinno, and L.F. Brass, A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment.
    • Blood, 2014. 124: 1816-23.
    • Welsh, J.D., T.J. Stalker, R. Voronov, R.W. Muthard, M. Tomaiuolo, S.L. Diamond, and L.F. Brass, A systems approach to hemostasis: 1.
    • The interdependence of thrombus architecture and agonist movements in the gaps between platelets. Blood, 2014. 124: 1808-15.
    • Law, D.A., F.R. DeGuzman, P. Heiser, K. Ministri-Madrid, N. Killeen, and D.R. Phillips, Integrin cytoplasmic tyrosine motif is required for outside-in alpha IIb beta 3 signalling and platelet function. Nature, 1999. 401: 808-811.
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