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McSorley, Stephen T.; Horgan, Paul G.; McMillan, Donald C. (2016)
Publisher: Elsevier B.V.
Languages: English
Types: Article
Subjects:
Background:\ud \ud This meta-analysis examined the impact of preoperative corticosteroids on interleukin 6 (IL-6), C-reactive protein (CRP), and complications following surgery for gastrointestinal cancer.\ud \ud Methods:\ud \ud A systematic review was performed using appropriate keywords. Random-effects meta-analysis was performed.\ud \ud Results:\ud \ud 11 RCTs with 474 patients, were included. Corticosteroids were significantly associated with lower IL-6 on postoperative day 1 (mean difference −148 pg/mL, 95% CI −205 to −92, p < 0.001), 2 (–33 pg/mL, 95% CI −58 to −8, p = 0.01), and 3 (–31 pg/mL, 95% CI −52 to −11, p = 0.002), lower CRP on day 3 (–45 mg/L, 95% CI −68 to −21, p<0.001), and 7 (–14 mg/L, 95% CI −27 to −1, p = 0.04), and fewer postoperative infective complications (OR 0.47, 95% CI 0.26 to 0.83, p = 0.01).\ud \ud Conclusion:\ud \ud Corticosteroids were associated with reduction in the postoperative systemic inflammatory response and complications following surgery for gastrointestinal cancer.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • Study or Subgroup 1.2.1 Colorectal Kirdak et al. 2008 1 14 5 13 Zargar-Shoshtari et al. 2009 9 29 11 31 Vignali et al. 2009 4 26 7 26 Subtotal (95% CI) 69 70 Total events 14 23 Heterogeneity: Tau² = 0.05; Chi² = 2.16, df = 2 (P = 0.34); I² = 7% Test for overall effect: Z = 1.43 (P = 0.15) 1.2.2 Oesophageal Matsutani et al. 1998 0 0 0 0 Sato et al. 2002 3 33 2 33 Takeda et al. 2003 0 7 0 10 Yano et al. 2005 3 20 7 20 Subtotal (95% CI) 60 63 Total events 6 9 Heterogeneity: Tau² = 0.45; Chi² = 1.60, df = 1 (P = 0.21); I² = 37% Test for overall effect: Z = 0.56 (P = 0.58) 9.9% 6 n
  • Inferred research data

    The results below are discovered through our pilot algorithms. Let us know how we are doing!

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    59%
    72
    72%
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