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Day, Jonathan; McKeever-Abbas, Ben; Dowden, James (2016)
Publisher: Wiley-VCH Verlag
Languages: English
Types: Article
Commercially available iron (III) and copper (I) complexes catalyze new multicomponent cycloadditions between diazo compounds, pyridines and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yields and diastereoselectivities. Hitherto, catalytic formation of versatile pyridinium ylides from metal carbenes has been poorly developed; the broad utility demonstrated herein sets the stage for invention of further multicomponent reactions in future.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

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