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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Trent, Simon; Davies, William (2013)
Publisher: Baishideng Publishing Group
Languages: English
Types: Article
Subjects: RC0321, BF, QH426
The enzyme steroid sulfatase (STS) desulfates a variety of steroid compounds thereby altering their activity. STS is expressed in the skin, and its deficiency in this tissue has been linked to the dermatological condition X-linked ichthyosis. STS is also highly expressed in the developing and adult human brain, and in a variety of steroidogenic organs (including the placenta and gonads); therefore it has the potential to influence brain development and function directly and/or indirectly (through influencing the hormonal milieu). In this review, we first discuss evidence from human and animal model studies suggesting that STS deficiency might predispose to neurobehavioural abnormalities and certain psychiatric disorders. We subsequently discuss potential mechanisms that may underlie these vulnerabilities. The data described herein have potential implications for understanding the complete spectrum of clinical phenotypes associated with X-linked ichthyosis, and may indicate novel pathogenic mechanisms underlying psychological dysfunction in developmental disorders such as attention deficit hyperactivity disorder and Turner syndrome.
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    • Endocr Rev 2005; 26: 1 1-202 [PMID: 15561802 DOI: 10.1210/
    • er.200 -0003]
    • J Steroid Biochem Mol Biol 200 ; 105: 115-123 [PMID: 1 60 15
    • DOI: 10.1016/j.jsbmb.2006.12.105]
    • activity disorder. Genes Brain Behav 2011; 10: 33 -3 [PMID:
    • 21255266 DOI: 10.1111/j.1601-183X.2010.006 2.x]
    • tion of aryl-and steroid sulfatases in brain. Brain Res 19 3; 59:
    • 3 9-358 [PMID: 61 DOI: 10.1016/0006-8993( 3)902 3- ]
    • hormones. Front Neuroendocrinol 2011; 32: 183-200 [PMID:
    • 2139 62 DOI: 10.1016/j.yfrne.2011.03.001]
    • cus in man. Proc Natl Acad Sci USA 1980; 77: 6 59-6 63 [PMID:
    • 6935682 DOI: 10.10 3/pnas. .11.6 59]
    • Cell 1988; 55: 1123-1135 [PMID: 3203382 DOI: 10.1016/0092-8
    • 1982; 299: 838-8 0 [PMID: 695 1 DOI: 10.1038/299838a0]
    • males and females. Biochem Mol Biol Int 1993; 30: 691-695
    • [PMID: 8 01326]
    • chem 200 ; 89: 03- 1 [PMID: 1505628 DOI: 10.10 6/
    • j.1 1- 159.200 .02336.x]
    • chiatr Genet 2010; 153B: 1 1 -1 2 [PMID: 20862695 DOI:
    • 10.1002/ajmg.b.31120]
    • inactivation. Mamm Genome 1996; 7: 20- 2 [PMID: 8662223
    • DOI: 10.100 /s003359900125]
    • steroid sulphatase gene (Sts). Nat Genet 1996; 13: 83-86 [PMID:
    • 86 3109 DOI: 10.1038/ng0596-83]
    • linked ichthyosis. Proc Natl Acad Sci USA 198 ; 84: 92 8-9251
    • [PMID: 3 805 1 DOI: 10.10 3/pnas.8 .2 .92 8]
    • sulphatase decfiiency). Nucleic Acids Res 198 ; 15: 39 -3985
    • [PMID: 288 621 DOI: 10.1093/nar/15.10.39 ]
    • steroid sulfatase locus. Proc Natl Acad Sci USA 1989; 86:
    • 8 -8 81 [PMID: 2813 06 DOI: 10.10 3/pnas.86.21.8 ]
    • exons 2-10 of the STS gene in recessive X-linked ichthyosis.
    • J Invest Dermatol 2000; 114: 591-593 [PMID: 10692123 DOI:
    • 10.10 6/j.1523-1 .2000.0092 .x]
    • Covarrubias SA. Deletion of exons 1-5 of the STS gene caus-
    • ing X-linked ichthyosis. J Invest Dermatol 2001; 116: 56-58
    • [PMID: 11231321 DOI: 10.10 6/j.1523-1 .2001.01259.x]
    • ichthyosis in a Mexican population. Mol Med 2001; 7: 8 5-8 9
    • [PMID: 118 8 2]
    • communication decfiits. J Med Genet 2008; 45: 519-52 [PMID:
    • 18 133 0 DOI: 10.1136/jmg.2008.05 29]
    • González-Sarmiento R. Analysis of the STS gene in 0 pa-
    • Venereol 2010; 24: 1226-1229 [PMID: 20236202 DOI: 10.1111/
    • j.1 68-3083.2010.03612.x]
    • Am J Hum Genet 200 ; 74: 552-55 [PMID: 1 963808 DOI:
    • urette syndrome. Eur J Hum Genet 2008; 16: 61 -618 [PMID:
    • 18231125 DOI: 10.1038/sj.ejhg.5202006]
    • Xp22.3, VCX-A, is deleted in patients with X-linked nonspe-
    • cific mental retardation. Am J Hum Genet 2000; 67: 563-5 3
    • [PMID: 10903929 DOI: 10.1086/3030 ]
    • X-linked ichthyosis. Hum Mol Genet 2005; 14: 1 95-1803
    • [PMID: 15888 81 DOI: 10.1093/hmg/ddi186]
    • dation. J Dermatol Sci 200 ; 45: 31-36 [PMID: 1 113 56 DOI:
    • 10.1016/j.jdermsci.2006.10.001]
    • of the VCX3A, VCX2 and VCX3B genes shows that VCX3A
    • in X-linked ichthyosis. Br J Dermatol 2008; 158: 83- 86 [PMID:
    • 180 6 0 DOI: 10.1111/j.1365-2133.200 .083 3.x]
    • Disabil Res 200 ; 51: 329-333 [PMID: 1 391250 DOI: 10.1111/
    • j.1365-2 88.2006.00880.x]
    • Med Genet 2008; 51: 68- 3 [PMID: 1819 880 DOI: 10.1016/
    • j.ejmg.200 .11.002]
    • G, Petit C, Ballabio A. A cluster of sulfatase genes on Xp22.3:
    • cations for warfarin embryopathy. Cell 1995; 81: 15-25 [PMID: 200 0 DOI: 10.1016/0092-86 (95)9036 - ]
    • drome. Horm Res 200 ; 67: 231-2 2 [PMID: 1 191030 DOI:
    • 1992; 50: 83- 91 [PMID: 1539590]
    • Chem 199 ; 272: 20 56-20 63 [PMID: 9252398 DOI: 10.10 /
    • jbc.2 2.33.20 56]
    • 199 ; 109: 2 -2 5 [PMID: 92 2515 DOI: 10.1111/1523-1 .
    • ep12319 ]
    • Invest Dermatol 2000; 114: 1195-1199 [PMID: 108 566 DOI:
    • 10.10 6/j.1523-1 .2000.0000 .x]
    • (Arg432Cys) in a patient with steroid sulphatase-decfiiency.
    • Clin Endocrinol (Oxf) 2003; 59: 263-26 [PMID: 1286 806 DOI:
    • 10.10 6/j.1365-2265.2003.1 851.x]
    • phys Acta 200 ; 1739: 1- [PMID: 1560 112]
    • a Japanese population. Drug Metab Pharmacokinet 2010; 25:
    • 03- 0 [PMID: 2081 163 DOI: 10.2133/dmpk.DMPK-10-
    • SC-02 ]
    • ichthyosis. J Dermatol Sci 2011; 63: 62-6 [PMID: 21530180
    • DOI: 10.1016/j.jdermsci.2011.03.011]
    • Annu Rev Genomics Hum Genet 2005; 6: 355-3 9 [PMID:
    • 1612 866 DOI: 10.11 6/annurev.genom.6.08060 .16233 ]
    • Venereol 1999; 79: 1 3-1 [PMID: 10228635 DOI: 10.1080/000
    • Dermatol 2010; 62: 80- 85 [PMID: 20080321 DOI: 10.1016/
    • j.jaad.2009.0 .028]
    • X-linked ichthyosis. Obstet Gynecol Surv 1986; 41: 01- 13
    • [PMID: 3531932]
    • unconjugated estriols. Prenat Diagn 2009; 29: 966-9 [PMID:
    • 196099 2 DOI: 10.1002/pd.2326]
    • 2010; 30: 893-898 [PMID: 20 15120 DOI: 10.1002/pd.2588]
    • Chromosome Res 2009; 17: 6 9-658 [PMID: 19802 05 DOI:
    • 10.100 /s105 -009-9052-z]
    • drome: a brief review. Pediatr Endocrinol Rev 2012; 9 Suppl 2:
    • 10- 12 [PMID: 229 6281]
    • 2012; 97: 260-265 [PMID: 21903599 DOI: 10.1136/archdis-
    • child-2011-300 82]
    • ing the MRX9 locus. J Med Genet 2001; 38: 66-0 [PMID:
    • Am J Med Genet A 2009; 149A: 1138-11 8 [PMID: 19 1126
    • DOI: 10.1002/ajmg.a.32833]
    • and research strategies. J Child Psychol Psychiatry 2003; 44:
    • 1092-1115 [PMID: 1 626 53 DOI: 10.1111/1 69- 610.0019 ]
    • of the literature. Acta Psychiatr Scand Suppl 2000; 401: 3-38
    • [PMID: 1088 9 8 DOI: 10.1111/j.0065-1591.2000.0ap25.x]
    • nia patients. J Clin Psychiatry 2012; 73: 1025-1033 [PMID:
    • 22901352 DOI: 10. 088/JCP.11m0 22]
    • Lynn PM, Davies W. The 39,XO mouse as a model for the
    • chiatric disorders. Behav Brain Res 200 ; 179: 1 3-182 [PMID:
    • 1 36 8 5 DOI: 10.1016/j.bbr.200 .02.013]
    • try 200 ; 61: 1351-1360 [PMID: 1 161381 DOI: 10.1016/
    • j.biopsych.2006.08.011]
    • Psychiatry 2009; 66: 360-36 [PMID: 19251250 DOI: 10.1016/
    • j.biopsych.2009.01.001]
    • Brain Res 200 ; 1174: 92-96 [PMID: 1 868658 DOI: 10.1016/
    • j.brainres.200 .0 .0 8]
    • mice. Genetics 199 ; 136: 225-230 [PMID: 8138160]
    • domestication. Proc Natl Acad Sci USA 2010; 107: 6 12-6 1
    • [PMID: 20308563 DOI: 10.10 3/pnas.091 39910 ]
    • ior in mice. Behav Genet 1999; 29: 131-136 [PMID: 10 05 62
    • DOI: 10.1023/A: 102166 60 131]
    • Brain Res 2001; 922: 216-222 [PMID: 11 3952 DOI: 10.1016/
    • S0006-8993(01)031 1- ]
    • activity disorder. Psychoneuroendocrinology 2012; 37: 221-229
    • [PMID: 21 23668 DOI: 10.1016/j.psyneuen.2011.06.006]
    • psychosis. J Womens Health (Larchmt) 2006; 15: 352-368
    • [PMID: 16 2 88 DOI: 10.1089/jwh.2006.15.352]
    • partum psychosis risk? Trends Mol Med 2012; 18: 256-262
    • [PMID: 22 5 35 DOI: 10.1016/j.molmed.2012.03.001]
    • Webster MJ, Barci BM, Torrey EF. Meta-analysis of 12 ge-
    • nomic studies in bipolar disorder. J Mol Neurosci 200 ; 31:
    • 221-2 3 [PMID: 1 26228]
    • bedside. Eur Neuropsychopharmacol 2006; 16: 155-169 [PMID:
    • 1625 183 DOI: 10.1016/j.euroneuro.2005.09.005]
    • chiatric disorders. Neuropsychobiology 2001; 43: 5- 8 [PMID:
    • 111 0 9 DOI: 10.1159/00005 8 0]
    • in 2 sisters. J Psychiatry Neurosci 2005; 30: 33-36 [PMID:
    • rology 2006; 67: 859-863 [PMID: 16966551 DOI: 10.1212/01.
    • wnl.000023 129.9 2 . d]
    • ity. Br J Dermatol 1981; 105: 11- 1 [PMID: 69 821 DOI:
    • 10.1111/j.1365-2133.1981.tb00983.x]
    • roendocrinology 2012; Epub ahead of print [PMID: 232 639
    • DOI: 10.1016/j.psyneuen.2012.12.002]
    • mice. Neuropsychopharmacology 2012; 37: 126 -12 [PMID:
    • 22189290 DOI: 10.1038/npp.2011.31 ]
    • steroid sulfatase deficiency. Arch Dermatol 2012; 148: 3- 8
    • [PMID: 21931015 DOI: 10.1001/archdermatol.2011.281]
    • 8. 1 Mb distal deletion of chromosome band Xp22.3 in a boy
    • mation. Am J Med Genet A 2008; 146A: 29 -29 9 [PMID:
    • 189256 6 DOI: 10.1002/ajmg.a.32 3]
    • pia. Pediatr Neurol 2006; 34: 239-2 1 [PMID: 1650 9 DOI:
    • 10.1016/j.pediatrneurol.2005.08.015]
    • Res 2008; 172: 51 -5 2 [PMID: 18 20 9 DOI: 10.1016/
    • S00 9-6123(08)00925- ]
    • Res 2008; 172: 5 3-565 [PMID: 18 2050 DOI: 10.1016/
    • S00 9-6123(08)00926-6]
    • gression. Adv Genet 2011; 75: 151-169 [PMID: 220 8 80 DOI:
    • 10.1016/B9 8-0-12-380858-5.00005-8]
    • Neuroscience 2012; 215: 2-58 [PMID: 225 26 2 DOI: 10.1016/
    • j.neuroscience.2012.03.065]
    • genes and puerperal psychosis: an association study. Psychiatr Genet 200 ; 17: 253-260 [PMID: 1 28663 DOI: 10.109 / YPG.0b013e3280ae6cc3]
    • 96 Pytliak M, Vargová V, Mechírová V, Felšöci M. Serotonin receptors - from molecular biology to clinical applications. Physiol Res 2011; 60: 15-25 [PMID: 209 5968]
    • 9 O'Neil RT, Emeson RB. Quantitative analysis of 5HT(2C) receptor RNA editing patterns in psychiatric disorders. Neurobiol Dis 2012; 45: 8-13 [PMID: 2191 81 DOI: 10.1016/ j.nbd.2011.08.026]
    • 98 Saulin A, Savli M, Lanzenberger R. Serotonin and molecular neuroimaging in humans using PET. Amino Acids 2012; 42: 2039-205 [PMID: 219 61 DOI: 10.100 /s00 26-011-10 8-9]
    • 99 Karishma KK, Herbert J. Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression. Eur J Neurosci 2002; 16: 5- 53 [PMID: 1219318 DOI: 10.10 6/j.1 60-9568.2002.02099.x]
    • 100 Li PK, Rhodes ME, Jagannathan S, Johnson DA. Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate. Brain Res Cogn Brain Res 1995; 2: 251-25 [PMID: 8580 38]
    • 101 Ciobanu LC, Luu-The V, Martel C, Labrie F, Poirier D. Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase. Cancer Res 2003; 63: 6 2-6 6 [PMID: 1 55983 ]
    • 102 Johnson DA, Rhodes ME, Boni RL, Li PK. Chronic steroid sulfatase inhibition by (p-O-sulfamoyl)-N-tetradecanoyl tyramine increases dehydroepiandrosterone sulfate in whole brain. Life Sci 199 ; 61: PL 355-359 [PMID: 9399636]
    • 103 Rhodes ME, Li PK, Burke AM, Johnson DA. Enhanced plasma DHEAS, brain acetylcholine and memory mediated by steroid sulfatase inhibition. Brain Res 199 ; 773: 28-32 [PMID: 9 09 01 DOI: 10.1016/S0006-8993(9 )0086 -6]
    • 10 Johnson DA, Wu T, Li P, Maher TJ. The effect of steroid sulfatase inhibition on learning and spatial memory. Brain Res 2000; 865: 286-290 [PMID: 1082193 ]
    • 105 Babalola PA, Fitz NF, Gibbs RB, Flaherty PT, Li PK, Johnson DA. The effect of the steroid sulfatase inhibitor (p-Osulfamoyl)-tetradecanoyl tyramine (DU-1 ) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract. Neurobiol Learn Mem 2012; 98: 303-310 [PMID: 23022361 DOI: 10.1016/j.nlm.2012.09.003]
    • 106 Klinkenberg I, Sambeth A, Blokland A. Acetylcholine and attention. Behav Brain Res 2011; 221: 30- 2 [PMID: 211089 2 DOI: 10.1016/j.bbr.2010.11.033]
    • 10 Vizi ES, Kiss JP. Neurochemistry and pharmacology of the major hippocampal transmitter systems: synaptic and nonsynaptic interactions. Hippocampus 1998; 8: 566-60 [PMID: 988201 ]
    • 108 Lykkesfeldt G, Bennett P, Lykkesfeldt AE, Micic S, Møller S, Svenstrup B. Abnormal androgen and oestrogen metabolism in men with steroid sulphatase decfiiency and recessive X-linked ichthyosis. Clin Endocrinol (Oxf) 1985; 23: 385-393 [PMID: 386 56 DOI: 10.1111/j.1365-2265.1985.tb01096.x]
    • 109 Traupe H, Happle R. Clinical spectrum of steroid sulfatase decfiiency: X-linked recessive ichthyosis, birth complications and cryptorchidism. Eur J Pediatr 1983; 140: 19-21 [PMID: 6135610 DOI: 10.100 /BF00661898]
    • 110 Axt-Gadermann M, Schlichting M, Küster W. Male-pattern baldness is common in men with X-linked recessive ichthyosis. Dermatology 2003; 207: 308-309 [PMID: 1 5 10 5 DOI: 10.1159/0000 3095]
    • 111 Gånemo A, Sjöden PO, Johansson E, Vahlquist A, Lindberg M. Health-related quality of life among patients with ichthyosis. Eur J Dermatol 200 ; 14: 61-66 [PMID: 1 965800]
    • 112 Qureshi A, Thaver D. Cross sectional review of children with ADHD presenting to an outpatient psychiatric institute in Pakistan. J Pak Med Assoc 2003; 53: 1- 3 [PMID: 1 620325]
    • 113 Vasconcelos MS, Sampaio AS, Hounie AG, Akkerman F, Curi M, Lopes AC, Miguel EC. Prenatal, perinatal, and postnatal risk factors in obsessive-compulsive disorder. Biol Psychiatry 200 ; 61: 301-30 [PMID: 1 123 5 DOI: 10.1016/ j.biopsych.2006.0 .01 ]
    • 11 Geller DA, Wieland N, Carey K, Vivas F, Petty CR, Johnson J, Reichert E, Pauls D, Biederman J. Perinatal factors affecting expression of obsessive compulsive disorder in children and adolescents. J Child Adolesc Psychopharmacol 2008; 18: 3 3-3 9 [PMID: 18 596 DOI: 10.1089/cap.200 .0112]
    • 115 Raynor MD, Oates MR. The psychology and psychopathology of pregnancy and childbirth. In: Fraser DM, Cooper MA, editors. Myles Textbook for Midwives. 1 th ed. Edinburgh: Churchill Livingstone, 2003: 653-6 1
    • 116 Foster PA, Reed MJ, Purohit A. Recent developments of steroid sulfatase inhibitors as anti-cancer agents. Anticancer Agents Med Chem 2008; 8: 32- 38 [PMID: 188555 5]
    • 11 Palmieri C, Januszewski A, Stanway S, Coombes RC. Irosustat: a rfist-generation steroid sulfatase inhibitor in breast cancer. Expert Rev Anticancer Ther 2011; 11: 1 9-183 [PMID: 213 203 DOI: 10.1586/era.10.201]
    • 118 Purohit A, Fusi L, Brosens J, Woo LW, Potter BV, Reed MJ. Inhibition of steroid sulphatase activity in endometriotic implants by 66 COUMATE: a potential new therapy. Hum Reprod 2008; 23: 290-29 [PMID: 18056119 DOI: 10.1093/ humrep/dem308]
    • 119 Stanway SJ, Purohit A, Woo LW, Sufi S, Vigushin D, Ward R, Wilson RH, Stanczyk FZ, Dobbs N, Kulinskaya E, Elliott M, Potter BV, Reed MJ, Coombes RC. Phase I study of STX 6 (667 Coumate) in breast cancer patients: the rfist study of a steroid sulfatase inhibitor. Clin Cancer Res 2006; 12: 1585-1592 [PMID: 16533 85 DOI: 10.1158/10 8-0 32.CCR-05-1996]
    • 120 Bukvic N, Cesarano C, Ceccarini C, Bruno M, Lipsi MR, Gallicchio MG, Carboni MA, Valente L, Cotoia G, Antonetti R. Characterization of the first adult de novo case of 6,X,der(Y)t(X; Y)(p22.3; q11.2). Gene 2013; 513: 111-11 [PMID: 2312 038 DOI: 10.1016/j.gene.2012.09.133]
    • 121 Sismani C, Anastasiadou V, Kousoulidou L, Parkel S, Koumbaris G, Zilina O, Bashiardes S, Spanou E, Kurg A, Patsalis PC. 9 Mb familial duplication in chromosome band Xp22.2-22.13 associated with mental retardation, hypotonia and developmental delay, scoliosis, cardiovascular problems and mild dysmorphic facial features. Eur J Med Genet 2011; 54: e510-e515 [PMID: 2168 358 DOI: 10.1016/ j.ejmg.2011.05.006]
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