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Karmiloff-Smith, Annette; D’Souza, Dean; Dekker, Tessa M.; Van Herwegen, Jo; Xu, Fei; Rodic, Maja; Ansari, Daniel (2012)
Publisher: National Academy of Sciences
Languages: English
Types: Article
Subjects: Biological Embedding of Early Social Adversity: From Fruit Flies to Kindergartners Sackler Colloquium
One might expect that children with varying genetic mutations or children raised in low socioeconomic status environments would display different deficits. Although this expectation may hold for phenotypic outcomes in older children and adults, cross-syndrome comparisons in infancy reveal many common neural and sociocognitive deficits. The challenge is to track dynamic trajectories over developmental time rather than focus on end states like in adult neuropsychological studies. We contrast the developmental and adult approaches with examples from the cognitive and social domains, and we conclude that static models of adult brain lesions cannot be used to account for the dynamics of change in genetic and environmentally induced disorders in children.
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    • 1. Butterworth B (2010) Foundational numerical capacities and the origins of dyscalculia. Trends Cogn Sci 14:534-541.
    • 2. Clahsen H, Temple CM (2003) Words and rules in children with William's syndrome. Language Competence Across Populations: Toward a Definition of Specific Language Impairment, eds Levy Y, Schaeffer J (Erlbaum, Hillsdale, NJ), pp 323-352.
    • 3. Karmiloff-Smith A (1998) Development itself is the key to understanding developmental disorders. Trends Cogn Sci 2:389-398.
    • 4. Karmiloff-Smith A (2009) Nativism versus neuroconstructivism: Rethinking the study of developmental disorders. Dev Psychol 45:56-63.
    • 5. Mareschal D, et al. (2007) Neuroconstructivism: How the Brain Constructs Cognition (Oxford Univ Press, Oxford).
    • 6. Farran EK, Karmiloff-Smith A (2012) Developmental Disabilities Across the Lifespan: A Neuroconstructivist Approach (Oxford Univ Press, Oxford).
    • 7. Johnson MH (2001) Functional brain development in humans. Nat Rev Neurosci 2: 475-483.
    • 8. Huttenlocher PR, Dabholkar AS (1997) Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol 387:167-178.
    • 9. Mills DL, Coffy-Corins S, Neville H (1997) Language comprehension and cerebral specialisation from 13-20 months. Dev Psychol 13:397-445.
    • 10. Meaney MJ, Szyf M (2005) Environmental programming of stress responses through DNA methylation: Life at the interface between a dynamic environment and a fixed genome. Dialogues Clin Neurosci 7:103-123.
    • 11. Thomas MSC, et al. (2009) Using developmental trajectories to understand developmental disorders. J Speech Lang Hear Res 52:336-358.
    • 12. Dehaene S (1997) The Number Sense: How the Mind Creates Mathematics (Oxford Univ Press, Oxford).
    • 13. Demeyere N, Lestou V, Humphreys GW (2010) Neuropsychological evidence for a dissociation in counting and subitizing. Neurocase 16:219-237.
    • 14. Brannon EM (2006) The representation of numerical magnitude. Curr Opin Neurobiol 16:222-229.
    • 15. Izard V, Dehaene-Lambertz G, Dehaene S (2008) Distinct cerebral pathways for object identity and number in human infants. PLoS Biol 6:e11.
    • 16. Lipton JS, Spelke ES (2003) Origins of number sense. Large-number discrimination in human infants. Psychol Sci 14:396-401.
    • 17. Xu F (2003) Numerosity discrimination in infants: Evidence for two systems of representations. Cognition 89:B15-B25.
    • 18. Xu F, Spelke ES (2000) Large number discrimination in 6-month-old infants. Cognition 74:B1-B11.
    • 19. Simon TJ (1997) Reconceptualizing the origins of number knowledge: A 'non-numerical' account. Cogn Dev 12:349-372.
    • 20. Van Herwegen J, Ansari D, Xu F, Karmiloff-Smith A (2008) Small and large number processing in infants and toddlers with Williams syndrome. Dev Sci 11:637-643.
    • 21. Paterson SJ, Brown JH, Gsödl MK, Johnson MH, Karmiloff-Smith A (1999) Cognitive modularity and genetic disorders. Science 286:2355-2358.
    • 22. O'Hearn K, Luna B (2009) Mathematical skills in Williams syndrome: Insight into the importance of underlying representations. Dev Disabil Res Rev 15:11-20.
    • 23. Ansari D, Donlan C, Karmiloff-Smith A (2007) Typical and atypical development of visual estimation abilities. Cortex 43:758-768.
    • 24. Paterson SJ, Girelli L, Butterworth B, Karmiloff-Smith A (2006) Are numerical impairments syndrome specific? Evidence from Williams syndrome and Down's syndrome. J Child Psychol Psychiatry 47:190-204.
    • 25. Brannon EM, Abbott S, Lutz DJ (2004) Number bias for the discrimination of large visual sets in infancy. Cognition 93:B59-B68.
    • 26. Xu F, Arriaga RI (2007) Number discrimination in 10-month-old infants. Br J Dev Psychol 25:103-108.
    • 27. Karmiloff-Smith A, Scerif G, Ansari D (2003) Double dissociations in developmental disorders? Theoretically misconceived, empirically dubious. Cortex 39:161-163.
    • 28. Casey BJ, Giedd JN, Thomas KM (2000) Structural and functional brain development and its relation to cognitive development. Biol Psychol 54:241-257.
    • 29. Gou Z, Choudhury N, Benasich AA (2011) Resting frontal gamma power at 16, 24 and 36 months predicts individual differences in language and cognition at 4 and 5 years. Behav Brain Res 220:263-270.
    • 30. Brown JH, et al. (2003) Spatial representation and attention in toddlers with Williams syndrome and Down syndrome. Neuropsychologia 41:1037-1046.
    • 31. Tobii (2003) Tobii User Manual (Tobii, Stockholm), 2nd Ed.
    • 32. Krakow JB, Kopp CB (1982) Sustained attention in young Down syndrome children. Topics Early Child Spec Educ 2:32-42.
    • 33. Casey BJ, Riddle M (2012) Typical and atypical development of attention. Cognitive Neuroscience of Attention, ed Posner MI (Guilford, New York), 2nd Ed., pp 345-356.
    • 34. Dakin SC, Tibber M, Greenwood JA, Kingdom FA, Morgan MJ (2011) A common visual metric for approximate number and density. Proc Natl Acad Sci USA 108: 19552-19557.
    • 35. Leonard HC, Annaz D, Karmiloff-Smith A, Johnson MH (2011) Developing spatial frequency biases for face recognition in autism and Williams syndrome. J Autism Dev Disord 41:968-973.
    • 36. Annaz D, Karmiloff-Smith A, Johnson MH, Thomas MSC (2009) A cross-syndrome study of the development of holistic face recognition in children with autism, Down syndrome, and Williams syndrome. J Exp Child Psychol 102:456-486.
    • 37. Choudhury N, Benasich AA (2011) Maturation of auditory evoked potentials from 6 to 48 months: Prediction to 3 and 4 year language and cognitive abilities. Clin Neurophysiol 122:320-338.
    • 38. Frith U (2003) Autism: Explaining the Enigma (Blackwell, Oxford).
    • 39. Barnard L, Muldoon K, Hasan R, O'Brien G, Stewart M (2008) Profiling executive dysfunction in adults with autism and comorbid learning disability. Autism 12: 125-141.
    • 40. Charman T, et al. (1997) Infants with autism: An investigation of empathy, pretend play, joint attention, and imitation. Dev Psychol 33:781-789.
    • 41. Elsabbagh M, et al. (2012) Infant neural sensitivity to dynamic eye gaze is associated with later emerging autism. Curr Biol 22:338-342.
    • 42. Karmiloff-Smith A (2012) Brain: The neuroconstructivist approach. Developmental Disabilities Across the Lifespan: A Neuroconstructivist Approach, eds Farran EK, Karmiloff-Smith A (Oxford Univ Press, Oxford), pp 37-58.
    • 43. Liston C, McEwen BS, Casey BJ (2009) Psychosocial stress reversibly disrupts prefrontal processing and attentional control. Proc Natl Acad Sci USA 106:912-917.
    • 44. Isaacs EB, Edmonds CJ, Chong WK, Lucas A, Gadian DG (2003) Cortical anomalies associated with visuospatial processing deficits. Ann Neurol 53:768-773.
    • 45. Isaacs EB, et al. (2010) Impact of breast milk on IQ, brain size and white matter development. Pediatr Res 67:357-362.
    • 46. Tottenham N, et al. (2009) Prolonged institutional rearing is associated with atypically larger amygdala volume and difficulties in emotion regulation. Dev Sci 13:46-61.
    • 47. Tottenham N, et al. (2011) Elevated amygdala response to faces following early deprivation. Dev Sci 14:190-204.
    • 48. John AE, Mervis CB (2010) Comprehension of the communicative intent behind pointing and gazing gestures by young children with Williams syndrome or Down syndrome. J Speech Lang Hear Res 53:950-960.
    • 49. Karmiloff-Smith A, et al. (2010) Constraints on the timing of infant cognitive change: Domain-specific or domain-general? Eur J Dev Sci 4:31-45.
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