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Cao, H; Amador, C; Jia, X; Li, YL; Ding, YL (2016)
Publisher: Elsevier
Languages: English
Types: Article

Classified by OpenAIRE into

arxiv: Physics::Fluid Dynamics
A mixing-tank model combining CFD simulation and Noyes–Whitney equation has been demonstrated for predicting dissolution of spray-dried detergent powder. The dissolution behaviour of bulk particles has been directly linked to the input power of the mixing system which is highly desired by industry with the aim of reducing testing when extrapolating particle dissolution performance from bench scale measurements to any washing system/condition. Initial particle parameters such as density, solubility, size distribution and diffusivity were considered. The model was first validated with experiment of non-porous single-ingredient particle Na2CO3 granules. Later, porous multi-ingredients particles from spray-drying pilot were used to validate the model with dissolution experiment data. The good agreements between experiment and simulation at different agitating speeds and temperatures illustrated that the model can be used for predicting bulk particles dissolving in a turbulent regime where they are well suspended in the mixing system. The CFD simulation results revealed detail information about energy dissipation rate across the vessel which explained the phenomena that when non-porous Na2CO3 granules were not well mixed in the system, dissolution predicted by modelling was much faster than experiment, indicating that local energy dissipation rate could be one solution to improve the modelling accuracy of this case.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • PTWS D610 Dual Drive Dissolution Tester.
    • Ansari, M.A., Stepanek, F., 2007. The Evolution of Microstructure in Three-Component Granulation and Its Effect on Dissolution. Particulate Science and Technology 26, 55-66.
    • Ansari, M.A., Stepanek, F., 2008. The effect of granule microstructure on dissolution rate.
    • Powder Technology 181, 104-114.
    • Arnout, S., Verhaeghe, F., Blanpain, B., Wollants, P., 2008. Lattice Boltzmann model for diffusion-controlled indirect dissolution. Computers & Mathematics with Applications 55, 1377- 1391.
    • Batchelor, G.K., 2000. An Introduction to Fluid Dynamics. Cambridge University Press.
    • Davidsohn, A., 1978. Spray drying and dry neutralization of powdered detergents. J Am Oil Chem Soc 55, 134-140.
    • Dressman, J.B., Fleisher, D., 1986. Mixing-Tank Model for Predicting Dissolution Rate Control of Oral Absorption. Journal of Pharmaceutical Sciences 75, 109-116.
    • Etacude, 2004-2008. Etacude.
    • Forny, L., Marabi, A., Palzer, S., 2011. Wetting, disintegration and dissolution of agglomerated water soluble powders. Powder Technology 206, 72-78.
    • Frenkel, J., 1946. Kinetic Theory of Liquids. Oxford: Clarendon Press.
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