LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Paciaroni, Maurizio; Agnelli, Giancarlo; Falocci, Nicola; Caso, Valeria; Becattini, Cecilia; Marcheselli, Simona; Rueckert, Christina; Pezzini, Alessandro; Poli, Loris; Padovani, Alessandro; Csiba, László; Szabó, Lilla; Sohn, Sung-Il; Tassinari, Tiziana; Abdul-Rahim, Azmil H.; Michel, Patrik; Cordier, Maria; Vanacker, Peter; Remillard, Suzette; Alberti, Andrea; Venti, Michele; Acciarresi, Monica; D'Amore, Cataldo; Mosconi, Maria Giulia; Scoditti, Umberto; Denti, Licia; Orlandi, Giovanni; Chiti, Alberto; Gialdini, Gino; Bovi, Paolo ... view all 72 authors View less authors (2016)
Publisher: Springer
Languages: English
Types: Article
Subjects: Acute stroke; Atrial fibrillation; Echocardiography; Outcome; Neurology (clinical); Neurology, Orvostudományok, Klinikai orvostudományok, Human medicine

Classified by OpenAIRE into

mesheuropmc: cardiovascular diseases
Abstract: Anticoagulant therapy is recommended for the secondary prevention of stroke in patients with atrial fibrillation (AF). T he identification of patients at high risk for early recurrence, which are potential candidates to prompt anticoagulation, is crucial to justify the risk of bleeding associated with early anticoagulant treatment. The aim of this study was to evaluate in patients with acute ischemic stroke and AF the association between findings at trans-thoracic echocardiography (TTE) and 90 days recurrence. In consecutive patients with acute ischemic stroke and AF, TTE was performed within 7 days from hospital admission. Study outcomes were recurrent ischemic cerebrovascular events (stroke or TIA) and systemic embolism. 854 patients (mean age 76.3 +/- A 9.5 years) underwent a TTE evaluation; 63 patients (7.4 %) had at least a study outcome event. Left atrial thrombosis was present in 11 patients (1.3 %) among whom 1 had recurrent ischemic event. Left atrial enlargement was present in 548 patients (64.2 %) among whom 51 (9.3 %) had recurrent ischemic events. The recurrence rate in the 197 patients with severe left atrial enlargement was 11.7 %. On multivariate analysis, the presence of atrial enlargement (OR 2.13; 95 % CI 1.06-4.29, p = 0.033) and CHA(2)DS(2)-VASc score (OR 1.22; 95 % CI 1.04-1.45, p = 0.018, for each point increase) were correlated with ischemic recurrences. In patients with AF-associated acute stroke, left atrial enlargement is an independent marker of recurrent stroke and systemic embolism. The risk of recurrence is accounted for by severe atrial enlargement. TTE-detected left atrial thrombosis is relatively uncommon.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Paciaroni M, Agnelli G, Falocci N, Caso V, Becattini C et al (2015) Early recurrence and cerebral bleeding in patients with acute ischemic stroke and atrial fibrillation: effect of anticoagulation and its timing: the RAF study. Stroke 46:2175-2182
    • 2. Douen AG, Sabin M, Pageau N (2008) Thrombus detection by echocardiography in patients with acute ischemic stroke and chronic or new-onset atrial fibrillation. J Stroke Cerebrovasc Dis 17:208-211
    • 3. Yaghi S, Moon YP, Mora-McLaughlin C, Willey JZ, Cheung K, Di Tullio MR et al (2015) Left atrial enlargement and stroke recurrence: the northern Manhattan stroke study. Stroke 46:1488-1493
    • 4. Tatu L, Moulin T, Bogousslavsky J, Duvemoy H (1998) Arterial territories of the human brain: cerebral hemispheres. Neurology. 50:1699-1708
    • 5. Tatu L, Moulin T, Bogousslavsky J, Duvemoy H (1996) Arterial territories of the human brain: brainstem and cerebellum. Neurology 47:1125-1135
    • 6. Paciaroni M, Agnelli G, Corea F, Ageno W, Alberti A, Lanari A et al (2008) Early hemorrhagic transformation of brain infarction: rate, predictive factors, and influence on clinical outcome: results of a prospective multicenter study. Stroke 39:2249-2256
    • 7. Beppu S, Park YD, Sakakibara H, Nagata S, Nimura Y (1984) Clinical features of intra-cardiac thrombus based on echocardiographic observation. Jpn Circ J 48:75-82
    • 8. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA et al (2005) Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standard Committee and the Chamber Quantification Writing Group, Developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 18:1440-1463
    • 9. Baumgartner H, Hung J, Bermejo J, Chambers JB, Evangelista A, Griffin BP, American Society of Echocardiography, European Association of Echocardiography et al (2009) Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice. J Am Soc Echocardiogr. 22:1-23
    • 10. Zoghbi WA, Enriquez-Sarano M, Foster E, Grayburn PA, Kraft CD, Levine RA, Nihoyannopoulos P, American Society of Echocardiography et al (2003) Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr 16:777-802
    • 11. De Bruijn SFTM, Agema WRP, Lammers GJ, van der Wall EE, Wolterbeek R, Holman ER et al (2006) Transesophageal echocardiography is superior to transthoracic echocardiography in management of patients of any age with transient ischemic attack or stroke. Stroke 37:2531-2534
    • 12. De Abreu TT, Mateus S, Carreteiro C, Correia J (2008) Therapeutic inplications of transesophageal echocardiography after transthoracic echocardiography on acute stroke patients. Vasc Health Risk Manag 4:167-172
    • 13. Osranek M, Bursi F, Bailey KR, Grossardt BR, Brown RD Jr, Kopecky SL et al (2005) Left atrial volume predicts cardiovascular events in patients originally diagnosed with lone atrial fibrillation: three-decade follow-up. Eur Heart J 26:2556-2561
    • 14. Kim TW, Jung SW, Song IU, Koo J, Choi HS, Lee KS et al (2015) Left atrial dilatation is associated with severe ischemic stroke in men with non-valvular atrial fibrillation. J Neurol Sci 354:97-102
  • No related research data.
  • No similar publications.