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Evstigneev, M.P.; Evstigneev, V.P.; Hernandez Santiago, A.A.; Davies, David B. (2006)
Publisher: Elsevier
Languages: English
Types: Article
Subjects: bcs
The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously. A model for analysis of ternary systems, which takes into account all possible complexes between the molecules, has been developed and tested with experimental NMR data on the three-component mixture FMN–CAF–NMD. The results indicate that special attention should be given to the concentration of a hydrotropic agent used to enhance the solubility of a particular drug. A decrease in the efficacy of solubility of the vitamin on addition of large amounts of hydrotropic agent is expected in the two-component systems due to the increased proportion of self-association of the hydrotrope. It is found that a mixture of two hydrotropic agents leads to an increase in the solubility of the vitamin in three-component compared to the two-component system. Rather than using just one hydrotropic agent, it is proposed that a strategy for optimising the solubility of aromatic drugs is to use a mixture of hydrotropic agents.
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    • Coffman, R.E., Kildsig, D.O., 1996a. Effect of nicotinamide and urea on the solubility of riboflavin in various solvents. J. Pharm. Sci. 85, 951-954.
    • Coffman, R.E., Kildsig, D.O., 1996b. Hydrotropic solubilization - Mechanistic studies. Pharm. Res. 13, 1460-1463.
    • Datta, S., Mukhopadhyay, C., Bose, S.K., 2003. Molecular complex formation between riboflavin and salicylate in an aqueous medium. Bull. Chem. Soc. Jpn. 76, 1729-1734.
    • Davies, D.B., Veselkov, D.A., Djimant, L.N., Veselkov, A.N., 2001. Hetero-association of caffeine and aromatic drugs and their competitive binding with a DNA oligomer. Eur. Biophys. J. 30, 354-366.
    • Evstigneev, M.P., Rozvadovskaya, A.O., Hernandez Santiago, A.A., Mukhina, Yu.V., Veselkov, K.A., Rogova, O.V., Davies, D.B., Veselkov, A.N., 2005a. A 1H NMR study of the association of caffeine with flavine mononucleotide in aqueous solutions. Russ. J. Phys. Chem. 79, 573-578.
    • Evstigneev, M.P., Davies, D.B., Veselkov, A.N., 2005b. Stochastic models (cooperative and non-cooperative) for NMR analysis of the hetero-association of aromatic molecules in aqueous solution. Chem. Phys. (in proofs).
    • Fawzi, M., Davison, E., Tute, M., 1980. Rationalization of drug complexation in aqueous solution by use of Huckel frontier molecular orbital calculations. J. Pharm. Sci. 69, 104-106.
    • Hussain, M.A., DiLuccio, R.C., Maurin, M.B., 1993. Complexation of moricizine with nicotinamide and evaluation of the complexation constants by various methods. J. Pharm. Sci. 82, 77-79.
    • Jain, N.K., Singhai, A.K., Jain, S., 1996. Hydrotropic solubilization of ketoprofen. Pharmazie. 51, 236-239.
    • Khalil, R.M., 1996. Interaction of ibuprofen and indomethacin with caffeine. Pharmazie. 51, 970-973.
    • Larsen, R.W., Jasuja, R., Hetzler, R.K., Muraoka, P.T., Andrada, V.G., Jameson, D.M., 1996. Spectroscopic and molecular modelling studies of caffeine complexes with DNA intercalators. Biophys. J. 70, 443-452.
    • Lim, L.-Y., Go, M.-L., 2000. Caffeine and nicotinamide enhances the aqueous solubility of the antimalarial agent halofantrine. Eur. J. Pharm. Sci. 10, 17-28.
    • Rasool, A., Hussain, A., Dittern, L.W., 1991. Solubility enhancement of some water-insoluble drugs in the presence of nicotinamide and related compounds. J. Pharm. Sci. 80, 387-393.
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