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Melchiorre, K; Sutherland, GR; Liberati, M; Thilaganathan, B (2012)
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Languages: English
Types: Article
Subjects:
Abstract—Fetal growth restriction and preeclampsia are both conditions of placental etiology and associated to increased\ud risk for the long-term development of cardiovascular disease in the mother. At presentation, preeclampsia is associated with maternal global diastolic dysfunction, which is determined, at least in part, by increased afterload and myocardial stiffness. The aim of this study is to test the hypothesis that women with normotensive fetal growth-restricted pregnancies also exhibit global diastolic dysfunction. This was a prospective case-control study conducted over a 3-year period involving 29 preterm fetal growth-restricted pregnancies, 25 preeclamptic with fetal growth restriction pregnancies, and 58 matched control pregnancies. Women were assessed by conventional echocardiography and tissue Doppler imaging at diagnosis of the complication and followed-up at 12 weeks postpartum. Fetal growth-restricted pregnancies are characterized by a lower cardiac index and higher total vascular resistance index than expected for gestation. Compared with controls, fetal growth-restricted pregnancy was associated with significantly increased prevalence (P�0.001) of asymptomatic left ventricular diastolic dysfunction (28% versus 4%) and widespread impaired myocardial relaxation\ud (59% versus 21%). Unlike preeclampsia, cardiac geometry and intrinsic myocardial contractility were preserved in fetal\ud growth-restricted pregnancy. Fetal growth-restricted pregnancies are characterized by a low output, high resistance circulatory state, as well as a higher prevalence of asymptomatic global diastolic dysfunction and poor cardiac reserve. These findings may explain the increased long-term cardiovascular risk in these women who have had fetal growth-restricted pregnancies. Further studies are needed to clarify the postnatal natural history of cardiac dysfunction in these women.
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    • 1. Ness RB, Sibai BM. Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia. Am J Obstet Gynecol. 2006;195:40-49.
    • 2. Yinon Y, Kingdom JC, Odutayo A, Moineddin R, Drewlo S, Lai V, Cherney DZ, Hladunewich MA. Vascular dysfunction in women with a history of preeclampsia and intrauterine growth restriction: insights into future vascular risk. Circulation. 2010;122:1846-1853.
    • 3. Sattar N. Do pregnancy complications and CVD share common antecedents [review]? Atheroscler Suppl. 2004;5:3-7.
    • 4. Smith GD, Harding S, Rosato M. Relation between infants' birth weight and mothers' mortality: prospective observational study. BMJ. 2000;320: 839-840.
    • 5. Paradisi G, Mattoli MV, Tomei C, Zuppi C, Lulli P, Quagliozzi L, Caruso A. Cardiovascular risk factors in healthy women with previous small for gestational age infants. J Obstet Gynaecol Res. 2011;37:1397-1404.
    • 6. Smith GC, Pell JP, Walsh D. Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129,290 births. Lancet. 2001;357:2002-2006.
    • 7. Manten GT, Sikkema MJ, Voorbij HA, Visser GH, Bruinse HW, Franx A. Risk factors for cardiovascular disease in women with a history of pregnancy complicated by preeclampsia or intrauterine growth restriction. Hypertens Pregnancy. 2007;26:39-50.
    • 8. Lykke JA, Langhoff-Roos J, Sibai BM, Funai EF, Triche EW, Paidas MJ. Hypertensive pregnancy disorders and subsequent cardiovascular morbidity and type 2 diabetes mellitus in the mother. Hypertension. 2009; 53:944-951.
    • 9. Mongraw-Chaffin ML, Cirillo PM, Cohn BA. Preeclampsia and cardiovascular disease death: prospective evidence from the child health and development studies cohort. Hypertension. 2010;56:166-171.
    • 10. Melchiorre K, Sutherland GR, Baltabaeva A, Liberati M, Thilaganathan B. Maternal cardiac dysfunction and remodeling in women with preeclampsia at term. Hypertension. 2011;57:85-93.
    • 11. Melchiorre K, Sutherland GR, Liberati M, Thilaganathan B. Preeclampsia is associated with persistent postpartum cardiovascular impairment. Hypertension. 2011;58:709-715.
    • 12. Melchiorre K, Thilaganathan B. Maternal cardiac function in preeclampsia [review]. Curr Opin Obstet Gynecol. 2011;23:440-447.
    • 13. Bamfo JE, Kametas NA, Turan O, Khaw A, Nicolaides KH. Maternal cardiac function in fetal growth restriction. BJOG. 2006;113:784-791.
    • 14. Vasapollo B, Valensise H, Novelli GP, Larciprete G, Di Pierro G, Altomare F, Casalino B, Galante A, Arduini D. Abnormal maternal cardiac function and morphology in pregnancies complicated by intrauterine fetal growth restriction. Ultrasound Obstet Gynecol. 2002;20: 452-457.
    • 15. Bamfo JE, Kametas NA, Chambers JB, Nicolaides KH. Maternal cardiac function in normotensive and pre-eclamptic intrauterine growth restriction. Ultrasound Obstet Gynecol. 2008;32:682-686.
    • 16. Bamfo JE, Kametas NA, Chambers JB, Nicolaides KH. Maternal cardiac function in fetal growth-restricted and non-growth-restricted small-forgestational age pregnancies. Ultrasound Obstet Gynecol. 2007;29:51-57.
    • 17. Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, Waggoner AD, Flachskampf FA, Pellikka PA, Evangelista A. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr. 2009;22:107-133.
    • 18. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise J, Solomon S, Spencer KT, St John Sutton M, Stewart W, for the American Society of Echocardiography's Nomenclature and Standards Committee; Task Force on Chamber Quantification; American College of Cardiology Echocardiography Committee; American Heart Association; European Association of Echocardiography; European Society of Cardiology. Recommendations for chamber quantification. Eur J Echocardiogr. 2006;7:79-108.
    • 19. Saltzman E, Benotti PN. Effects of obesity on the cardiovascular system. In: Bray GA, Bouchard C, eds. Handbook of Obesity: Etiology and Pathophysiology. 2nd ed. New York, NY: Marcel Dekker Ltd;2003: 825-843.
    • 20. Bouchard DR, Langlois MF, Brochu M, Dionne IJ, Baillargeon JP. Metabolically healthy obese women and functional capacity. Metab Syndr Relat Disord. 2011;9:225-229.
    • 21. Utz W, Engeli S, Haufe S, Kast P, Hermsdorf M, Wiesner S, Pofahl M, Traber J, Luft FC, Boschmann M, Schulz-Menger J, Jordan J. Myocardial steatosis, cardiac remodelling and fitness in insulin-sensitive and insulinresistant obese women. Heart. 2011;97:1585-1589.
    • 22. Zibadi S, Cordova F, Slack EH, Watson RR, Larson DF. Leptin's regulation of obesity-induced cardiac extracellular matrix remodeling. Cardiovasc Toxicol. 2011;11:325-333.
    • 23. Wu CK, Yang CY, Lin JW, Hsieh HJ, Chiu FC, Chen JJ, Lee JK, Huang SW, Li HY, Chiang FT, Tsai CT. The relationship among central obesity, systemic inflammation, and left ventricular diastolic dysfunction as determined by structural equation modeling. Obesity (Silver Spring). 2012;20:730-737.
    • 24. Hwang YC, Jee JH, Kang M, Rhee EJ, Sung J, Lee MK. Metabolic syndrome and insulin resistance are associated with abnormal left ventricular diastolic function and structure independent of blood pressure and fasting plasma glucose level. Int J Cardiol. March 9, 2011. DOI: 10.1016/ j.ijcard.2011.02.039. http://www.internationaljournalofcardiology.com/ article/S0167-5273%2811%2900200-2/fulltext. Accessed June 13, 2012.
    • 25. Zandstra M, Stekkinger E, van der Vlugt MJ, van Dijk AP, Lotgering FK, Spaanderman ME. Cardiac diastolic dysfunction and metabolic syndrome in young women after placental syndrome. Obstet Gynecol. 2010;115: 101-108.
    • 26. Deswal A. Diastolic dysfunction and diastolic heart failure: mechanisms and epidemiology [review]. Curr Cardiol Rep. 2005;7:178-183.
    • 27. Koopmans CM, Blaauw J, van Pampus MG, Rakhorst G, Aarnoudse JG. Abnormal endothelium-dependent microvascular dilator reactivity in pregnancies complicated by normotensive intrauterine growth restriction. Am J Obstet Gynecol. 2009;200:66.e1-66.e6.
    • 28. Johnson MR, Anim-Nyame N, Johnson P, Sooranna SR, Steer PJ. Does endothelial cell activation occur with intrauterine growth restriction? BJOG. 2002;109:836-839.
    • 29. Poppas A, Shroff SG, Korcarz CE, Hibbard JU, Berger DS, Lindheimer MD, Lang RM. Serial assessment of the cardiovascular system in normal pregnancy. Role of arterial compliance and pulsatile arterial load. Circulation. 1997;20:2407-2415.
    • 30. Carbillon L, Uzan M, Uzan S. Pregnancy, vascular tone, and maternal hemodynamics: a crucial adaptation. Obstet Gynecol Surv. 2000;55: 574-581.
    • 31. Jessup M, Abraham WT, Casey DE, Feldman AM, Francis GS, Ganiats TG, Konstam MA, Mancini DM, Rahko PS, Silver MA, Stevenson LW, Yancy CW. 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults; a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119:1977-2016.
    • 32. Ammar KA, Jacobsen SJ, Mahoney DW, Kors JA, Redfield MM, Burnett JC Jr, Rodeheffer RJ. Prevalence and prognostic significance of heart failure stages:application of the American College of Cardiology/ American Heart Association heart failure staging criteria in the community. Circulation. 2007;115:1563-1570.
    • 33. Kuznetsova T, Herbots L, Jin Y, Stolarz-Skrzypek K, Staessen JA. Systolic and diastolic left ventricular dysfunction: from risk factors to overt heart failure. Expert Rev Cardiovasc Ther. 2010;8:251-258.
    • 34. Vogel MW, Slusser JP, Hodge DO, Chen HH. The natural history of preclinical diastolic dysfunction: a population based study. Circ Heart Fail. 2012;5:144-151.
    • 35. Gardosi J, Mongelli M, Chang A. An adjustable fetal weight standard. Ultrasound Obstet Gynecol. 1995;6:168-174.
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