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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Johannessen, E.A.; Wang, L.; Wyse, C.; Cumming, D.R.S.; Cooper, J.M. (2006)
Publisher: IEEE
Languages: English
Types: Article
Subjects: T1, R1

Classified by OpenAIRE into

mesheuropmc: digestive, oral, and skin physiology
n this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These two parameters have potential application for use in remote biological sensing (for example they may be used as markers that reflect the physiological environment or as indicators for disease, within the gastrointestinal tract). We have investigated the effects of biofouling on these sensors, by exploring their response time and sensitivity in a model in vitro gastrointestinal system. The artificial gastric and intestinal solutions used represent a model both for fasting, as well as for the ingestion of food and subsequent digestion to gastrointestinal chyme. The results showed a decrease in pH sensitivity after exposure of the sensors for 3 h. The response time also increased from an initial measurement time of 10 s in pure GI juice, to ca. 25 s following the ingestion of food and 80 s in simulated chyme. These in vitro results indicate that changes in viscosity in our model gastrointestinal system had a pronounced effect on the unmodified sensor.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

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    • [26] L. Sherwood, Human Physiology from Cells to Systems, 2 ed. Minneapolis, MN: West, 1993, p. 745. Cathy Wyse received the B.A. (Hons) degree in equine science from Coventry University, Coventry, U.K., in 1996, and the M.Sc. degree in veterinary science from the University of Glasgow, Glasgow, U.K., in 1999. The Ph.D. degree was awarded in 2003, following a collaborative project between the Division of Veterinary Clinical Studies, and the Division of Bioelectronics at the University of Glasgow. She is currently working as a Research Associate at the University of Bristol, Bristol, U.K. Her research interests include the development of novel diagnostic methods in veterinary medicine, and on factors affecting performance in racehorses. Jonathan M. Cooper received the B.Sc. degree in biological sciences from the University of Southampton, Southampton, U.K., in 1983 and the Ph.D. degree in sensor technology from the University of Cranfield, Bedfordshire, U.K., in 1989. He is a Professor of Bioelectronics and Bioengineering in the Department of Electronic and Electrical Engineering at the University of Glasgow, Glasgow, U.K. His research interests lie in the areas of biosensors for clinical diagnostics, Lab-on-a-Chip technologies and Bionanotechnology. He was elected as a fellow of the Royal Society of Edinburgh and of the Royal Academy of Engineering.
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